Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
This study was aimed at elucidating regulatory mechanisms of neural functions by sulfated glycans. Keratan sulfate inhibits axon regeneration. In a set of ocular dominance plasticity, keratan sulfate also regulates functional innervation into binocular region from non-deprived eye through regulation of LTP in the critical period. We also found that chondroitin sulfate and its receptors, PTPRσ and LAR, regulate autophagy, dystrophic endball formation and consequently axon regeneration.
Attribution of KAKENHI