2015 Fiscal Year Final Research Report
Regulatory mechanisms of neuronal activity by chondroitin sulfate chains
| Project Area | Deciphering sugar chain-based signals regulating integrative neuronal functions |
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| Project/Area Number |
23110003
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Jun-ichi 鳥取大学, 地域学部, 教授 (30221401)
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| Co-Investigator(Renkei-kenkyūsha) |
NADANAKA Satomi 神戸薬科大学, 薬学部, 講師 (60378578)
MIKAMI Tadahisa 神戸薬科大学, 薬学部, 講師 (20330425)
MIYATA Shinji 名古屋大学, 生命農学研究科, 特任助教 (60533792)
SATO Ban 筑波大学, 生命環境系生物科学分野, 特任助教 (90443126)
HIRAOKA Syuichi 神戸薬科大学, 薬学部, 研究員 (20291156)
KITAZAWA Kazuyuki 神戸薬科大学, 薬学部, 特別契約研究員 (30770333)
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| Research Collaborator |
EIRAKU Hoshiko
YUZUDOU Noriko
SIDA Miharu
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | プロテオグリカン / コンドロイチン硫酸 / 神経可塑性 / 抑制性神経細胞 / グリコサミノグリカン / 糖鎖受容体 / 糖鎖シグナル / ペリニューロナルネット |
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| Outline of Final Research Achievements |
Chondroitin sulfate (CS), a major component of the brain extracellular matrix, is reported to play a role in controlling critical period plasticity. Digestion of CS chains has shown to restore visual cortical plasticity in adult animals, but the underlying mechanisms remain unknown. CS chain is a linear polysaccharide consisting of repeating disaccharide units that can be substituted with sulfate groups at various positions, thereby producing characteristic sulfation patterns. Thus we hypothesized that sulfation patterns of CS chains regulate the critical period plasticity. Using transgenic mouse model overexpressing chondroitin 6-sulfotransferase-1, we found that a developmental increase in the 4-sulfation/6-sulfation ratio of CS chains leads to the termination of the critical period in the mouse visual cortex. These results suggest that specific sulfation patterns of CS chains regulate the maturation of parvalbumin-expressing interneurons.
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| Free Research Field |
生化学・分子生物学・糖鎖生物学
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