2015 Fiscal Year Final Research Report
Golgi stress response and glycosylation in neural function
Project Area | Deciphering sugar chain-based signals regulating integrative neuronal functions |
Project/Area Number |
23110007
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | University of Hyogo |
Principal Investigator |
YOSHIDA HIDEROU 兵庫県立大学, 生命理学研究科, 教授 (60378528)
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Co-Investigator(Renkei-kenkyūsha) |
WAKABAYASHI SADAO 兵庫県立大学, 大学院生命理学研究科, 准教授 (80148436)
TANIGUCHI MAI 兵庫県立大学, 大学院生命理学研究科, 助教 (00423898)
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Project Period (FY) |
2011-04-01 – 2016-03-31
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Keywords | 神経 / 糖鎖 / ゴルジ体 / ストレス応答 / 細胞小器官 / 小胞体 / 小胞輸送 / 細胞生物学 |
Outline of Final Research Achievements |
The Golgi apparatus has an important role in neural function. For instance, dendrites contain Golgi outpost, a well developed Golgi structure critical for glycosylation and vesicular transport of membrane and secretory proteins. In this research project, we identified four response pathways of the mammalian Golgi stress response, that is, the TFE3, proteoglycan, mucin and glycosphingolipid pathways, revealed the activation mechanism for TFE3, a key transcription factor for the TFE3 pathway, and found that insufficiency of sialic acid modification is involved in activation of the TFE3 pathway. Moreover, we demonstrated that the Golgi stress response is essential for differentiation of glial cells.
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Free Research Field |
細胞生物学
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