2016 Fiscal Year Final Research Report
Molecular mechanisms for maintenance of the integrity of nervous tissues by glycosphingolipids
| Project Area | Deciphering sugar chain-based signals regulating integrative neuronal functions |
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| Project/Area Number |
23110008
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Chubu University (2015-2016)
Nagoya University (2011-2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 健一 京都大学, 物質－細胞統合システム拠点, 特定拠点准教授 (50423059)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | ガンングリオシド / ノックアウト / 脂質ラフト |
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| Outline of Final Research Achievements |
Functions and action mechanisms of gangliosides that are highly expressed in nervous systems have been analyzed using glycolipid-deficient mutant mice with focus on their regulatory functions in lipid rafts. Using neuron-specific transgenic mice of B4galnt1, it was shown that gangliosides play roles in neurons for maintenance of the integrity of nervous tissues. Analysis of St8sia1 knockout mice revealed that b-series gangliosides are essential in the secretion of leptin from adipocytes, and that a-series gangliosides are crucial for the sensitivity of leptin receptor in hypothalamus. It was also demonstrated that GD2/GD3 ebhances malignant properties of gliomas by forming a molecular complex with PDGFRalpha and Yes in a mouse glioma model.
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| Free Research Field |
生化学、糖鎖生物学
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