2016 Fiscal Year Final Research Report
Study of the regulation of synaptic plasticity regulated extracellular micro environment underlying the higher brain function
| Project Area | Deciphering sugar chain-based signals regulating integrative neuronal functions |
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| Project/Area Number |
23110010
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Research Collaborator |
OKA Shogo 京都大学, 大学院
KAWASAKI Nana 横浜市立大学, 大学院
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | グルタミン酸受容体 / シナプス可塑性 / 糖鎖修飾 |
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| Outline of Final Research Achievements |
Glutamate is a main excitatory neurotransmitter in central nervous system and its receptor, glutamate receptors, play important roles in many neuronal functions including memory. In particular, AMPA-type glutamate receptor (AMPA-R) plays central roles in not only main excitatory neurotransmission, but also expression of synaptic plasticity. In this project, we will focus on N-glycosylation of AMPA-R, and we aim to elucidate their functions in synaptic transmission and plasticity. We already found that non-glycosylated AMPA-R is preferentially localized in lipid raft on the cell membrane and this localization has altered channel property, missing desensitization. We also revealed that there are raft-positive and -negative synapses in the same neuron, proposing the hypothesis that glycosylation of AMPA―R decides the synaptic localization, resulting in the regulation of synaptic strength in synaptic plasticity.
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| Free Research Field |
Neuroscience
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