Brain environment and neurodegeneration based on optineurin mutations

2015 Fiscal Year Final Research Report

• Project Area: Brain Environment
• Project/Area Number: 23111008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hiroshima University
• Principal Investigator: Kawakami Hideshi 広島大学, 原爆放射線医科学研究所, 教授 (70253060)
• Co-Investigator(Kenkyū-buntansha): KATO HIDEMASA 愛媛大学, 大学院医学研究科, 准教授 (50292123)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 神経疾患 / モデル動物

Outline of Final Research Achievements

To clarify the function of optineurin , which we found as a causative gene of amyotrophic lateral sclerosis, and to make the model mouse of amyotrophic lateral sclerosis, we made the optineurin knock-out mouse. We observed the behavior and body weight of the knock-out mouse, and we found no difference between the controls and the knock-out mouse.

Free Research Field

神経内科学