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2016 Fiscal Year Final Research Report

Regulation of cell polarity and cell fates in tissue stem/progenitor cells

Planned Research

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Project AreaRegulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure
Project/Area Number 23112003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionYokohama City University

Principal Investigator

OHNO Shigeo  横浜市立大学, 医学研究科, 教授 (10142027)

Co-Investigator(Renkei-kenkyūsha) HIROSE Tomonori  横浜市立大学, 医学部, 講師 (20381668)
SASAKI Kazunori  横浜市立大学, 医学部, 助教 (50438131)
NAKAYA Masaaki  横浜市立大学, 医学部, 助教 (70422095)
GOULAS Spyros  横浜市立大学, 医学研究科, 特任助教 (90644352)
Research Collaborator IIDA Naoko  
SATOH Daisuke  
SAROH Yoshinori  
TAMURA Kana  
MINEMATSU Naoko  
TAKAYANAGI Ayumi  
FUJITA Ryouhei  
Project Period (FY) 2011-04-01 – 2016-03-31
Keywords幹細胞 / シグナル伝達 / 細胞極性 / 上皮組織 / 発生・分化 / がん / 乳腺 / 再生医学
Outline of Final Research Achievements

The cellular and molecular mechanisms governing the formation and the maintenance of epithelial architecture remains unclear. By using the mammary gland as a model, we have succeeded in clarifying the positive role of a polarity protein, aPKC, on stem cell proliferation. Interestingly, the same protein play a negative role on proliferation of luminal precursor cells. we further explored the mechanism; aPKC regulates different transcription factors positively, and negatively in each cases. These results seems to explain part of the mechanism for different mammary cancer types and can be used as a diagnostic marker.

Free Research Field

分子細胞生物学

URL: 

Published: 2018-03-22  

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