Regulation of cell polarity and cell fates in tissue stem/progenitor cells

2016 Fiscal Year Final Research Report

• Project Area: Regulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure
• Project/Area Number: 23112003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Yokohama City University
• Principal Investigator: OHNO Shigeo 横浜市立大学, 医学研究科, 教授 (10142027)
• Co-Investigator(Renkei-kenkyūsha): HIROSE Tomonori 横浜市立大学, 医学部, 講師 (20381668) ; SASAKI Kazunori 横浜市立大学, 医学部, 助教 (50438131) ; NAKAYA Masaaki 横浜市立大学, 医学部, 助教 (70422095) ; GOULAS Spyros 横浜市立大学, 医学研究科, 特任助教 (90644352)
• Research Collaborator: IIDA Naoko ; SATOH Daisuke ; SAROH Yoshinori ; TAMURA Kana ; MINEMATSU Naoko ; TAKAYANAGI Ayumi ; FUJITA Ryouhei
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 幹細胞 / シグナル伝達 / 細胞極性 / 上皮組織 / 発生・分化 / がん / 乳腺 / 再生医学

Outline of Final Research Achievements

The cellular and molecular mechanisms governing the formation and the maintenance of epithelial architecture remains unclear. By using the mammary gland as a model, we have succeeded in clarifying the positive role of a polarity protein, aPKC, on stem cell proliferation. Interestingly, the same protein play a negative role on proliferation of luminal precursor cells. we further explored the mechanism; aPKC regulates different transcription factors positively, and negatively in each cases. These results seems to explain part of the mechanism for different mammary cancer types and can be used as a diagnostic marker.

Free Research Field

分子細胞生物学