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2014 Fiscal Year Final Research Report

Functional analysis of mesoscopic neural network involved in generation of wakefulness

Planned Research

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Project AreaMesoscopic neurocircuitry: towards understanding of the functional and structural basis of brain information processing
Project/Area Number 23115103
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University (2012-2014)
National Institute for Physiological Sciences (2011)

Principal Investigator

YAMANAKA Akihiro  名古屋大学, 環境医学研究所, 教授 (60323292)

Co-Investigator(Kenkyū-buntansha) MORI Takuma  生理学研究所, 助教 (70545798)
Project Period (FY) 2011-04-01 – 2015-03-31
Keywords視床下部 / ペプチド作動性神経 / パッチクランプ / 光遺伝学 / 神経活動操作 / 運命制御 / 時期特異的脱落 / 睡眠覚醒
Outline of Final Research Achievements

Sleep disorder Narcolepsy is caused by the specific degeneration of orexin-producing neurons in the hypothalamus. This suggests that orexin neurons play an important role in the regulation of sleep/wakefulness, especially in the maintenance of wakefulness. To study development mechanism of narcolepsy in mice, we generated new narcolepsy model mice which enable ablate orexin neurons with timing-controlled manner. Using these mice, we revealed the relationship between remaining number of orexin neurons and development of narcoleptic symptoms.

Free Research Field

神経生理学

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Published: 2016-06-03  

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