Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Sleep disorder Narcolepsy is caused by the specific degeneration of orexin-producing neurons in the hypothalamus. This suggests that orexin neurons play an important role in the regulation of sleep/wakefulness, especially in the maintenance of wakefulness. To study development mechanism of narcolepsy in mice, we generated new narcolepsy model mice which enable ablate orexin neurons with timing-controlled manner. Using these mice, we revealed the relationship between remaining number of orexin neurons and development of narcoleptic symptoms.
Attribution of KAKENHI