2015 Fiscal Year Final Research Report
Crosstalk of transcriptional status and amino acid metabolism
| Project Area | Crosstalk of transcriptional control and energy pathways by hub metabolites |
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| Project/Area Number |
23116004
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Hidekazu 山口大学, 医学系研究科, 講師 (90450402)
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| Co-Investigator(Renkei-kenkyūsha) |
DAITOKU Hiroaki 筑波大学, 生命環境系, 講師 (30361314)
HIROTA Keiko 筑波大学, 生命環境系, 助教 (00375370)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | メチル化 / S-アデノシルメチオニン / 線虫 |
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| Outline of Final Research Achievements |
The intercellular methyl group donor S-adenosyl-L-methionine (SAM) is produced in the methionine cycle. In this study, we investigated the crosstalk between methionine metabolism and methylation levels in the transcriptional environment. We first established the highly sensitive measurement system for detecting cellular methionine and SAM. In addition, by using C. elegans as a model organism, we revealed that food-derived methionine affects methylation levels of histones by being converted into SAM and one of phospholipid synthases that consumes a large amount of SAM is involved in lifespan regulation.
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| Free Research Field |
分子生物学
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