Lipid mediators in allergy and immunity

2014 Fiscal Year Final Research Report

• Project Area: Machineries of bioactive lipids in homeostasis and diseases
• Project/Area Number: 23116101
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: MIYACHI Yoshiki 京都大学, 医学(系)研究科(研究院), 教授 (30127146)
• Co-Investigator(Kenkyū-buntansha): HONDA Tetsuya 京都大学, 医学研究科, 准教授 (40452338) ; KITOH Akihiko 京都大学, 医学研究科, 助教 (40508438)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 免疫 / アレルギー / 皮膚科学

Outline of Final Research Achievements

Prostanoids, which include prostaglandin and thromboxane, are metabolites of arachidonic acid released in various pathophysiological conditions. They induce a range of actions mediated through their respective receptors expressed on target cells. It has been demonstrated that each prostanoid receptor has multiple functions and that the effect of receptor stimulation can vary depending on context; this sometimes results in opposing effects, such as simultaneous excitatory and inhibitory outcomes. The balance between the production of each prostanoid and the expression of its receptors has been shown to be important for maintaining homeostasis but also involved in the development of various pathological conditions such as allergy.

Free Research Field

皮膚科学