2014 Fiscal Year Final Research Report
Roles of prostanoids in facilitation of lymphangiogenesis and lymph node metastasis
| Project Area | Machineries of bioactive lipids in homeostasis and diseases |
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| Project/Area Number |
23116102
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Tomoe 北里大学, 医学部, 講師 (20296510)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | プロスタグランジン / サイクロオキシゲナーゼ / リンパ管新生 / がんリンパ節転移 / 慢性炎症 / 浮腫 / 前転移ニッテェ / 樹状細胞 |
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| Outline of Final Research Achievements |
Lymphatic vasculature forms a network of vessels that drain interstitial fluid from tissues and return this fluid to the blood. Lymphangiogesis, the formation of lymphatic vessels from preexisting lymphatic vessels, plays an important role in homeostasis of interstitial fluids and immunity. We found that lymphangiogenesis in chronic inflammation and secondary lymphedema was regulated by COX-2. The lymphatic system is an important route for cancer dissemination, and lymph node metastasis (LNM) serves as a critical prognostic determinant in cancer patients. We clarified contribution of COX-2-derived PGE2 in formation of a premetastatic niche and LNM. Stromal cell-derived factor-1 (SDF-1) was elevated in DCs before LLC cell infiltration to lymph nodes, and was important to form premetastatic niche. Accumulation of Tregs and lymph node lymphangiogenesis was also COX-2/EP3-dependent. These results indicate that DCs induce a premetastatic niche via COX-2/EP3-dependent induction of SDF-1.
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| Free Research Field |
薬理学
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