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2013 Fiscal Year Annual Research Report

メタ認知と社会行動の発達にもとづく自己制御

Planned Research

Project AreaAdolescent mind and self-regulation
Project/Area Number 23118003
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

藤井 直敬  独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (20392095)

Co-Investigator(Kenkyū-buntansha) 橋本 龍一郎  首都大学東京, 人文科学研究科(研究院), 准教授 (00585838)
萩原 裕子  首都大学東京, 人文科学研究科(研究院), 教授 (20172835)
福田 正人  群馬大学, 大学院医学系研究科, 准教授 (20221533)
岡ノ谷 一夫  東京大学, 大学院総合文化研究科, 教授 (30211121)
酒井 弘  広島大学, 教育学研究科(研究院), 教授 (50274030)
Project Period (FY) 2011-07-25 – 2016-03-31
Keywords自己制御
Research Abstract

橋本は自閉症スペクトラム障害(以下ASDと略記)を対象として、自己・他者参照処理について、自己と他者の視点の切り替えに伴う脳活動の変化が、ASDと健常者では異なる脳領域を発見した。酒井はヴァーチャル・リアリティ装置(SRシステム)を使用し、因果関係の推論と認知が非日常的な経験によってどのように影響を被るのかを探る研究を理研の藤井チームと実施した。藤井はネットワーク間構造から社会的認知メカニズムを明らかにすること、さらにネットワーク構造間に相互依存性があることを示した。萩原は具体的には、「自分の声」の識別に関して、第3フォルマント以上の高い周波数帯域において、自分の声が他人の声よりも識別しやすいことを明らかにした。岡ノ谷はノイズ音を回避するよう歌を修正する学習行動(ノイズ回避学習)を利用した実験により、間隙の時間長の可塑性が成鳥で示された。また、行動修正能は発達段階で異なることを示した。福田は統合失調症において、左側頭部の脳賦活は陽性陰性症状評価尺度the Positive and Negative Syndrome Scale (PANSS)で評価した不統合症状と負の相関を、右下前頭部の脳賦活はPANSSの陰性症状や不統合症状および罹病期間と負の相関があることを示した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

順調に研究計画は進展しており、大きな問題はないと考えられる。

Strategy for Future Research Activity

橋本は現在取り組んでいる自己の声のオンライン制御に関する萩原との共同研究を推進し、論文化を目指す。データ収集はほぼ完了しており、データ解析の結果を検討しながら、追加実験が必要か、専門誌に論文の投稿が可能かを検討しながら研究を進める。酒井は、SRシステムを使用した実験の準備を急ぎ、7月~9月を目処に実施する予定である。同時に、事象関連電位を使用した実験の準備がほぼ完了しているため、5月~6月を目処に実験を実施する予定である。藤井はニホンザルを用いた社会性課題を継続し、社会的文脈に応じて行動を切り替える適応行動の動的メカニズムを明らかにする。萩原は、基本周波数とフォルマント周波数の解析結果をあわせて検討することで、発声の自己制御システムのモデル化を目指す。また、すでに収集した質問紙調査のデータを解析することで、発声の制御に関係がある「自己に対する意識の要因」を明らかにする。岡ノ谷はジュウシマツの歌可塑性:歌の可塑性を様々な日齢群で調べることで、自己制御能力の発達的変化を検討する。また薬理操作と神経活動計測を組み合わせた手法で可塑性を調整する神経機構を調べる。福田は、自己制御についての脳機能の検討を、①会話という対人関係における自己制御の脳機能の検討対象をうつ病や双極性障害へと広げること、②会話における脳機能を2人同時に検討してその関連を検討すること、③対人関係の困難が中心的な病態である広汎性発達障害の脳機能を自己制御と関連づけて検討することを目指す。

  • Research Products

    (48 results)

All 2014 2013

All Journal Article (12 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 2 results) Presentation (33 results) (of which Invited: 7 results) Book (3 results)

  • [Journal Article] Neuroimaging-aided differential diagnosis of the depressive state2014

    • Author(s)
      Takizawa R, Fukuda M, Kawasaki S, Kasai K, Mimura M, Pu S, Noda T, Niwa S, Okazaki Y, JPSY-NIRS Group
    • Journal Title

      NeuroImage

      Volume: 85 Pages: 498-507

    • DOI

      10.1016/j.neuroimage.2013.05.126

    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Functional abnormalities in the left ventrolateral prefrontal cortex during a semantic fluency task, and their association with thought disorder in patients with schizophrenia.2014

    • Author(s)
      Marumo K, Takizawa R, Kinou M, Kawasaki S, Kawakubo Y, Fukuda M, Kasai K
    • Journal Title

      NeuroImage

      Volume: 85 Pages: 518-526

    • DOI

      10.1016/j.neuroimage.2013.04.050

    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An artificial network model for estimating the network structure underlying partially observed neuronal signals2014

    • Author(s)
      Komatsu M, Namikawa J, Chao ZC, Nagasaka Y, Fujii N, Nakamura K and Tani J
    • Journal Title

      Neurosci. Res.

      Volume: in press Pages: in press

    • Peer Reviewed
  • [Journal Article] Semi-automatic classification of birdsong elements using a linear support vector machine.2014

    • Author(s)
      Ryosuke O. Tachibana, Naoya Oosugi, Kazuo Okanoya
    • Journal Title

      PLOS ONE

      Volume: 9 Pages: e92584

    • Peer Reviewed
  • [Journal Article] 臨床神経生理学から見た精神疾患の病態生理.精神経誌:.2014

    • Author(s)
      福田正人
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 187-193

  • [Journal Article] Acoustic cues for the recognition of self-voice and other-voice2013

    • Author(s)
      Xu, M., Homae, F., Hashimoto, R., Hagiwara, H.
    • Journal Title

      Frontiers in Psychology

      Volume: 4 Pages: 1,7

    • Peer Reviewed
  • [Journal Article] Temporal distance between the cause and the effect affects the reading of causality sentences: Eye-tracking evidence2013

    • Author(s)
      Luo, Y
    • Journal Title

      Japanese Institute of Electronics, Information and Communication Engineers Technical Report

      Volume: 113 Pages: 139,144

  • [Journal Article] Projections of events and propositions in Japanese: A case study of koto-nominalized clauses in causal relations2013

    • Author(s)
      Hara, Y
    • Journal Title

      Lingua: International Review of General Linguistics

      Volume: 133 Pages: 262,288

    • Peer Reviewed
  • [Journal Article] Large-scale information flow in conscious and unconscious states: an ECoG study in monkeys.2013

    • Author(s)
      Yanagawa T, Chao ZC, Hasegawa N,Fujii N
    • Journal Title

      PLoS One

      Volume: 8(11) Pages: e80845

    • Peer Reviewed
  • [Journal Article] Differential spatiotemporal characteristics of the prefrontal hemodynamic response and their association with functional impairment in schizophrenia and major depression2013

    • Author(s)
      Kinou M, Takizawa R, Marumo K, Kawasaki S, Kawakubo Y, Fukuda M, Kasai K
    • Journal Title

      Schizophr Res

      Volume: in press Pages: in press

    • Peer Reviewed
  • [Journal Article] A NIRS-fMIR investigation of prefrontal cortex activity during a working memory task2013

    • Author(s)
      Sato H, Yahata N, Funane T, Takizawa R, Katura T, Atsumori H, Nishimura Y, Kinoshita A, Kiguchi M, Koizumi H, Fukuda M, Kasai K
    • Journal Title

      NeuroImage

      Volume: 83 Pages: 158-173

    • Peer Reviewed
  • [Journal Article] Temporal lobe and inferior frontal gyrus dysfunction in patients with schizophrenia during face-to-face conversation: a near-infrared spectroscopy study2013

    • Author(s)
      Takei Y, Suda M, Aoyama Y, Yamaguchi M, Sakurai N, Narita K, Fukuda M, Mikuni M
    • Journal Title

      J Psychiat Res

      Volume: 47 Pages: 1581-9

    • Peer Reviewed
  • [Presentation] Temporal Distance between the Cause and the Effect Affects the Reading of Causality Sentences: Eye-Tracking Evidence2014

    • Author(s)
      Luo, Y
    • Organizer
      Mental Architecture for Processing and Learning of Language 2014
    • Place of Presentation
      大阪
    • Year and Date
      20140804-20140804
  • [Presentation] Neural basis for adaptive adjustment of local temporal structure of birdsong2013

    • Author(s)
      Ryosuke O. Tachibana, Neal A. Hessler, Kazuo Okanoya
    • Organizer
      The 18th Auditory Research Forum
    • Place of Presentation
      Shiga Japan
    • Year and Date
      20131214-20131214
  • [Presentation] An electrocorticographic electrode array for simultaneous recording from medial, lateral, and intrasulcal surface of the cortex in the macaque monkey2013

    • Author(s)
      N. FUJII, M. FUKUSHIMA, R. C. SAUNDERS, M. MULLARKEY, M. MISHKIN
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20131113-20131113
  • [Presentation] Mapping retinotopic organization in monkey cortex by independent component analysis on electrocortical signals2013

    • Author(s)
      Z. C. CHAO, K. TAKAURA, N. FUJII
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20131113-20131113
  • [Presentation] Retinotopic organization of the monkey visual cortex studied with electrcorticogram (ECoG) recording2013

    • Author(s)
      K. TAKAURA, N. TSUCHIYA, N. FUJII
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20131113-20131113
  • [Presentation] Estimation of the number of internal states in the brain as an indicator for the conscious level and content: An ECoG study in monkeys2013

    • Author(s)
      T. YANAGAWA, N. OOSUGI, N. HASEGAWA, N. FUJII
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20131112-20131112
  • [Presentation] Estimating a network structure that underlies partially observed neuronal signals2013

    • Author(s)
      M. KOMATSU, J. NAMIKAWA, Z. C. CHAO, Y. NAGASAKA, N. FUJII, K. NAKAMURA, J. TANI
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20131112-20131112
  • [Presentation] Substitutional Reality for research in animal cognition2013

    • Author(s)
      Y. NAGASAKA, S. WAKISAKA, T. NOTOYA, N. FUJII
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20131110-20131110
  • [Presentation] Real-world neuroimagingしてのNIRSの意義2013

    • Author(s)
      福田正人
    • Organizer
      第43回,日本臨床神経生理学会学術大会
    • Place of Presentation
      高知
    • Year and Date
      20131108-20131108
    • Invited
  • [Presentation] Self-regulation of speech production in response to modulated auditory feedback2013

    • Author(s)
      Xu, M., Tachibana, R., Homae, F., Hashimoto, R., Okanoya, K., & Hagiwara, H.
    • Organizer
      International Symposium “Adolescent brain & mind and self-regulation”
    • Place of Presentation
      東京
    • Year and Date
      20131027-20131027
  • [Presentation] Neural substrates for cognitive control of metacognition in high-functioning adults with autism spectrum disorder2013

    • Author(s)
      Yamada, T., Nakamura, M., Itahashi, T., Watanabe, H., Kanai, C., Takayama, Y., Ohno, T., Tani, M., Iwanami, A., Kato, N., & Hashimoto, R.
    • Organizer
      International Symposium “Adolescent brain & mind and self-regulation”
    • Place of Presentation
      東京
    • Year and Date
      20131027-20131027
  • [Presentation] Order, Temporal Distance and Causal Relatedness in Representing Causation: Evidence from Eye-Tracking2013

    • Author(s)
      Luo, Y
    • Organizer
      Adolescent Brain & Mind and Self-Regulation
    • Place of Presentation
      東京
    • Year and Date
      20131027-20131027
  • [Presentation] A neural mechanism for adaptive song regulation in Bengalese finches2013

    • Author(s)
      Ryosuke O. Tachibana, Neal A. Hessler, Kazuo Okanoya
    • Organizer
      International symposium of adolescent brain & mind and self-regulation
    • Place of Presentation
      Tokyo
    • Year and Date
      20131027-20131027
  • [Presentation] The Effects of Melatonin Productivity for Courtship Ultrasonic Vocalization in C57BL/6J Mice.2013

    • Author(s)
      Yui K Matsumoto, Takaoki Kasahara, Kazuo Okanoya
    • Organizer
      International symposium of adolescent brain & mind and self-regulation
    • Place of Presentation
      Tokyo
    • Year and Date
      20131027-20131027
  • [Presentation] Metacognitive self-regulation in rats2013

    • Author(s)
      Yuki Shoko, Kazuo Okanoya
    • Organizer
      International symposium of adolescent brain & mind and self-regulation
    • Place of Presentation
      Tokyo
    • Year and Date
      20131027-20131027
  • [Presentation] Real-world Neuroimaging in Psychiatry using Near-infrared Spectroscopy (Symposium 2: Cognition and Emotion in Schizophrenia and Mood Disorders: Findings from Lab and Real-World)2013

    • Author(s)
      Fukuda M, Suda M, Takei Y, Sakurai N, Yamaguchi M, Aoyama Y, Takahashi K, Narita K
    • Organizer
      The 15th Anniversary Meeting of Korean Society for Schizophrenia Research “New Horizons of Schizophrenia”
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20131025-20131025
    • Invited
  • [Presentation] Self-Recognition in Socio-Cultural Context: Linguistic, Behavioral, and Neurophysiological Evidence(招待講演)2013

    • Author(s)
      Sakai, H
    • Organizer
      Tokyo Conference on Philosophy of Psychiatry
    • Place of Presentation
      東京
    • Year and Date
      20130920-20130920
    • Invited
  • [Presentation] メラトニン合成能がC57BL/6Jマウスの行動に与える影響2013

    • Author(s)
      松本結, 岡ノ谷一夫, 笠原和起
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波
    • Year and Date
      20130915-20130915
  • [Presentation] 酬量水準はラットの時間割引場面での選好に影響する2013

    • Author(s)
      結城笙子,岡ノ谷一夫
    • Organizer
      第73回日本動物心理学会
    • Place of Presentation
      筑波
    • Year and Date
      20130915-20130915
  • [Presentation] Multiple sources of temporal variability in song of Bengalese finches (Lonchura striata var. domestica)2013

    • Author(s)
      Ryosuke O. Tachibana, Kazuo Okanoya
    • Organizer
      Behaviour 2013
    • Place of Presentation
      The Sage Gateshead, NewcastleGateshead, UK
    • Year and Date
      20130804-20140808
  • [Presentation] 精神疾患についての臨床応用の現状(シンポジウム2:NIRSの最前線)2013

    • Author(s)
      福田正人,須田真史,武井雄一, 山口実穂,桜井敬子,成田耕介
    • Organizer
      第15回 日本ヒト脳機能マッピング学会
    • Place of Presentation
      東京
    • Year and Date
      20130705-20130705
    • Invited
  • [Presentation] Frontal lobe dysfunction in pervasive developmental disorder revealed by multichannel near-infrared spectroscopy (NIRS)2013

    • Author(s)
      Sato T, Narita H, Takei Y, Suda M, Sakurai N, Yamaguchi M, Narita K, Fukuda M, Mikuni M
    • Organizer
      The 11th World Congress of Psychiatry
    • Place of Presentation
      Kyoto
    • Year and Date
      20130627-20130627
  • [Presentation] Hemodynamic changes of psychiatric diseases during a face-to-face conversation2013

    • Author(s)
      Suda M, Takei Y, Kawasaki S, Sakurai N, Narita K, Fukuda M, Mikuni M :
    • Organizer
      The 11th World Congress of Psychiatry
    • Place of Presentation
      Kyoto
    • Year and Date
      20130627-20130627
  • [Presentation] Real-world neuroimaging in psychiatry using near-infrared spectroscopy (Satellite Symposium SA-05: Schizophrenia as a disorder of adolescent mind and self-regulation)2013

    • Author(s)
      Fukuda, M
    • Organizer
      The 11th World Congress of Psychiatry
    • Place of Presentation
      Kyoto
    • Year and Date
      20130625-20130625
    • Invited
  • [Presentation] A machine-leaning-based biomarker for autism spectrum disorder using resting-state functional magnetic resonance imaging2013

    • Author(s)
      Yahata, N., Morimoto, J., Hashimoto, R., Shibata, K., Imamizu, H., Fukuda, M., Kawakubo, Y., Yamada, T., Sasaki, Y., Kato, N., Watanabe, T., Kasai, K., & Kawato, M.
    • Organizer
      11th World Congress of Biological Psychiatr
    • Place of Presentation
      京都
    • Year and Date
      20130624-20130624
  • [Presentation] Joint gray and white matters’ alterations in adults with autism spectrum disorder revealed by joint independent component analysis2013

    • Author(s)
      Itahashi, T., Nakamura, M., Jimbo, D., Yamada, T., Watanabe, H., Kanai, C., Yamagata, B., Shioda, S., Toriizuka, K., Kato, N., & Hashimoto, R.
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Year and Date
      20130624-20130624
  • [Presentation] 結合ニューロフィードバックによる精神疾患の治療の可能性(招待講演)2013

    • Author(s)
      橋本龍一郎
    • Organizer
      Neuro2013 (日本神経科学学会・日本神経化学会・日本神経回路学会 合同大会)
    • Place of Presentation
      京都
    • Year and Date
      20130622-20130622
    • Invited
  • [Presentation] 成人高機能自閉症の脳機能的ネットワークの変化2013

    • Author(s)
      板橋貴史、山田貴志、神保大樹、渡部洋実、中村元昭、山県文、金井智恵子、鳥居塚和生、加藤進昌、橋本龍一郎
    • Organizer
      Neuro2013 (日本神経科学学会・日本神経化学会・日本神経回路学会 合同大会)
    • Place of Presentation
      京都
    • Year and Date
      20130622-20130622
  • [Presentation] 安静時脳機能画像を用いた機能学習による自閉症スペクトラム障害のバイオマーカー開発2013

    • Author(s)
      八幡憲明、森本淳、橋本龍一郎、柴田和久、今水敏、福田恵、川久保友紀、山田貴志、佐々木由香、加藤進昌、渡邊武男、笠井清登、川人光男
    • Organizer
      Neuro2013 (日本神経科学学会・日本神経化学会・日本神経回路学会 合同大会
    • Place of Presentation
      京都
    • Year and Date
      20130622-20130622
  • [Presentation] 非侵襲脳画像とニューロフィードバック(招待講演)2013

    • Author(s)
      橋本龍一郎
    • Organizer
      Neuro2013 (日本神経科学学会・日本神経化学会・日本神経回路学会 合同大会)
    • Place of Presentation
      京都
    • Year and Date
      20130621-20130621
    • Invited
  • [Presentation] 音声の認識における自己と他者2013

    • Author(s)
      徐鳴鏑、保前文高、橋本龍一郎、萩原裕子
    • Organizer
      Neuro2013 (日本神経科学学会・日本神経化学会・日本神経回路学会 合同大会)
    • Place of Presentation
      京都
    • Year and Date
      20130621-20130621
  • [Presentation] Control mechanism of temporal pattern in birdsong of Bengalese finch (Lonchura striata var domestica)2013

    • Author(s)
      Ryosuke O. Tachibana, Neal A. Hessler, Kazuo Okanoya
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Year and Date
      20130620-20130623
  • [Presentation] Adaptive adjustment of local temporal structure in song of Bengalese finches2013

    • Author(s)
      Ryosuke O. Tachibana, Neal A. Hessler, Kazuo Okanoya
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Year and Date
      20130620-20130623
  • [Book] 発達精神病理としての統合失調症-脳と生活と言葉. In:福田正人,糸川昌成,村井俊哉,笠井清登編(2013)『統合失調症』2013

    • Author(s)
      福田正人
    • Total Pages
      59-66
    • Publisher
      医学書院
  • [Book] 『統合失調症』2013

    • Author(s)
      福田正人,糸川昌成,村井俊哉, 笠井清登
    • Total Pages
      753
    • Publisher
      医学書院
  • [Book] NIRS In:山内俊雄・松田博史『脳画像でみる精神疾患』2013

    • Author(s)
      福田正人,須田真史,小池進介, 西村幸香,川久保友紀,野田隆政, 吉田寿美子
    • Total Pages
      91-110
    • Publisher
      新興医学出版社

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Published: 2015-05-28  

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