Design and Analysis for Dynamical Genetic Circuits based on various Mathematical Models

2015 Fiscal Year Final Research Report

• Project Area: Synthetic biology for the comprehension of biomolecular networks
• Project/Area Number: 23119008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: YAMAMURA Masayuki 東京工業大学, 総合理工学研究科, 教授 (00220442)
• Co-Investigator(Renkei-kenkyūsha): KONAGAYA Akihiko 東京工業大学, 総合理工学研究科, 教授 (00301200) ; SUZUKI Yasuhiro 名古屋大学, 情報科学研究科, 准教授 (50292983) ; KOBAYASHI Tetsuya 東京大学, 生産技術研究所, 准教授 (90513359) ; MOCHIZUKI Atsushi 理化学研究所, 望月理論生物学研究室, 主任研究員 (10304726) ; TAKAYASU Misako 東京工業大学, 総合理工学研究科, 准教授 (20296776) ; ONO Isao 東京工業大学, 総合理工学研究科, 准教授 (20078166) ; ITO Hiroshi 九州大学, 芸術工学研究院, 助教 (20512627) ; SEKINE Ryoji 理化学研究所, 生命システム研究センター, 研究員 (70730232)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 人工遺伝子回路 / 非線形動力学 / 確率過程 / 複雑ネットワーク / 並列シミュレーション

Outline of Final Research Achievements

The research plan is devided into following five subgoals. (1) We achieved to model fundamental processes such as gene regulation and inter cellular communication, collaborating with Kiga-project. (2) We achieved to design oscillating artificial genetic circuits by using genetic algorithms with frequency characteristics as the fitness evaluation. (3) We analized cascading two artificial genetic circuit from the viewpoint of impedance matching. (4) We proposed a multicellular developement model for multi layered bacterial sheet in hot fountain. (5) In order to build common modeling bench for Synthetic Biology, we collect necessary mathematical methodology such as non-linear differencial equation system, stochastic process system, cellular automata system, and so on.

Free Research Field

システム科学