Design automation of multi-element gene circuits

2015 Fiscal Year Final Research Report

• Project Area: Synthetic biology for the comprehension of biomolecular networks
• Project/Area Number: 23119009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: The University of Tokyo
• Principal Investigator: Iba Hitoshi 東京大学, 情報理工学(系)研究科, 教授 (40302773)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 遺伝子ネットワーク / 進化計算 / DNAツールボックス / ラボラトリーオートメーション / 遺伝的アルゴリズム / 遺伝的プログラミング / 人工遺伝子回路

Outline of Final Research Achievements

The design of genetic networks has been studied for implementing desired biological systems, and in particular, some researchers have proposed automatic design methods using optimization techniques. However, it is difficult to implement genetic networks designed by previous methods due to overly simplified model descriptions whose parameters are infeasible in the real world. Additionally, the methods do not ensure robustness against parameter perturbation. In this project, we have proposed an effective design method and a fitness function evaluating robustness to create genetic networks which can be implemented experimentally. Further, we suggest the knowledge about robust network structures from results of optimization.

Free Research Field

進化計算