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2015 Fiscal Year Final Research Report

Imaging and manipulation of the neural circuits for decision making

Planned Research

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Project AreaElucidation of neural computation for prediction and decision making: toward better human understanding and applications
Project/Area Number 23120008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Okamoto Hitoshi  国立研究開発法人理化学研究所, 脳科学総合研究センター, シニアチームリーダー (40183769)

Project Period (FY) 2011-04-01 – 2016-03-31
Keywords意思決定 / ゼブラフィッシュ / イメージング / トランスジェニック / カルシウム標識蛍光タンパク / オプトジェネティックス
Outline of Final Research Achievements

The aim of this study was to image the activities of the neurons which regulate decision making and ultimately to elucidate the neural mechanisms of decision making by taking advantage of the minimum size of the telencephalon of the adult zebrafish. We revealed that two different neural ensembles in the telencephalic pallium encode the behavioral rules for escape and stay. We also showed that the activities of the neurons in the ventral habenula and their direct targets, the serotonergic neurons in the median raphe,encode the expectation value of the future negative reward. We further have succeeded in establishing the virtual reality environment in which the neural activities of the whole brain of live adult zebrafish can be observed.

Free Research Field

分子神経回路行動学

URL: 

Published: 2017-05-10  

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