Construction of multi-molecular information conversion devices by employing nucleic acid nanostructures

2016 Fiscal Year Final Research Report

• Project Area: Development of Molecular Robots equipped with sensors and intelligence
• Project/Area Number: 24104002
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyoto University
• Principal Investigator: Hirohide Saito 京都大学, iPS細胞研究所, 教授 (20423014)
• Co-Investigator(Kenkyū-buntansha): 遠藤 政幸 京都大学, 物質-細胞統合システム拠点, 准教授 (70335389) ; 瀧ノ上 正浩 東京工業大学, 総合理工学研究科(研究院), 准教授 (20511249) ; 鈴木 泰博 名古屋大学, 情報科学研究科, 准教授 (50292983)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: 分子ロボティクス / DNAナノ構造 / RNA/RNPナノ構造 / 分子センサー・人工レセプター / リポソーム / 人工細胞モデル / 自律性 / 少数分子化学反応

Outline of Final Research Achievements

To realize molecular robots with ‘sensor functions’, our group studied the construction of ‘multilevel molecular information conversion devices’, which can detect various molecular input signals at the level of a single molecule and can convert them to intended internal information. We first constructed an artificial receptor-type molecular sensor device and then achieved a ‘sense’ of molecular robots. In addition, we constructed asymmetric complex-shaped bodies for molecular robot that can load molecular sensor devices. Furthermore, we studied theoretical research of chemical reactions with small number of molecules for noise reduction in molecular information sensing. To apply molecular sensor devices to in vivo systems, we constructed RNA-type molecular robots that can detect molecular information and convert it in cells. As a result, these studies contributed to the aim of this Grant-in-Aid for Scientific Research on Innovative Areas, Molecular Robotics.

Free Research Field

生命工学