プラズマ医療のための気相・表界面反応ダイナミクスの計測と体系化

2014 Fiscal Year Annual Research Report

• Project Area: Plasma medical innovation
• Project/Area Number: 24108002
• Research Institution: Nagoya University
• Principal Investigator: 堀 勝 名古屋大学, 工学(系)研究科(研究院), 教授 (80242824)
• Co-Investigator(Kenkyū-buntansha): 鈴置 保雄 名古屋大学, 工学(系)研究科(研究院), 教授 (10115587) ; 加藤 昌志 名古屋大学, 医学(系)研究科(研究院), 教授 (10281073) ; 秋山 真一 名古屋大学, 医学(系)研究科(研究院), 講師 (20500010) ; 平松 美根男 名城大学, 理工学部, 教授 (50199098) ; 近藤 博基 名古屋大学, 工学(系)研究科(研究院), 准教授 (50345930)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: プラズマ / ラジカル / 液中プラズマ / システムバイオロジー / メラノーマ

Outline of Annual Research Achievements

①超高電子密度大気圧プラズマ（NEAPP）の気相・液相計測と表界面反応の解明：研究代表者は、AC励起NEAPPジェットを細胞培養液に照射して、プラズマ活性溶液（PAM）の生成機構を解明している。雰囲気ガスの巻き込みによる気相中活性種をレーザー誘起蛍光分光（LIF）法によるOHラジカルの空間分布計測で行い、液相内のH2O2など活性種の生成機構について重要な知見を得た。A01節原班、A02池原班、A03平田班、田中班らとの共同研究で異なる構造のプラズマ源のプラズマパラメータや気相活性種の計測を進めた。液相中の活性種についても、スピントラップ電子スピン共鳴（ESR）法、化学プローブ法、イオンクロマトグラフィーの計測を公募近藤班や分担研究者らと行い、PAM内に窒酸化物が特徴的に生成することが分かった。
②NEAPP及びPAMの医療応用と細胞内分子機構の解明：A03吉川班との共同研究により、NEAPPの直接照射により起こるDNA酸化損傷や脂質過酸化の照射時間依存性が計測された。公募足立班との共同研究により、PAMがA549肺腺癌細胞においてはカスパーゼ非依存的アポトーシスを誘導することが分かった。研究分担者との共同研究により、NEAPPの直接照射により良性メラノーマ腫瘍が悪性に転化するときに遺伝子発現が増大するサイクリン遺伝子やメタロプロテアーゼ遺伝子の発現を抑えられることが分かった。名古屋大学医学部との共同研究により、（消化器外科）PAMが胃がん細胞に対してもアポトーシスを誘導し、（医学部眼科）PAMがレーザーにより誘起された脈絡膜新生血管を抑制することが分かった。
③バイオ材料の表面加工技術の開発：バイオ基材となるナノ材料などのパターン形成およびプラズマ表面化学修飾の効果の検討を進めた。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

①超高密度大気圧プラズマ（NEAPP）の気相・液相計測と表界面反応の解明：これまでに構築してきた医療プラズマ時空間粒子計測装置と生体表界面解析装置によって気相と液相ならびに生体表面の活性種生成とそれらの反応を体系的に解明するに至り、順調に進んでいる。特に異なる構造のプラズマ源の液相活性種の生成機構の相違について研究成果が進展した。
②NEAPP及びプラズマ活性溶液(PAM)の医療応用と細胞内分子機構の解明：PAMを用いた医療応用が当初の予想以上に波及効果をもたらし、名古屋大学医学部や岐阜薬科大学との共同研究の成果が次々と論文としてまとめられ公表された。PAMによる脳腫瘍培養細胞の選択的殺傷効果とその細胞内分子機構についてPlasma Medicine誌に報告した論文はその雑誌内において最もダウンロードされた論文となり、また国際会議において、PAMに関するセクションが設けられた。プラズマあるいはPAMによりアポトーシスが起こる細胞内分子機構についても新しい知見が次々と得られており、我が国がプラズマがん治療の作用機序の解明を先導して行っていると言える。
③バイオ材料の表面加工技術の開発：パターン形成基板上への細胞接着状態の特性把握を実施した。

Strategy for Future Research Activity

①超高電子密度大気圧プラズマ(NEAPP)の気相・液相計測と表界面反応の解明：平成27年度は引き続き、各種プラズマ装置から供給される気相活性種の時空間分布の計測とともに、それら測定データを元にしたラジカルと光の寄与についても分析を進める。液相反応活性種については、共同研究を進めて新たに計測手法を導入し未知の有機物などを探索する。液中反応を総括化学反応モデリング等により定量的な分析にも取り組み、生体表界面反応機構の解明を目指す。
②NEAPP及びプラズマ活性溶液(PAM)の医療応用と細胞内分子機構の解明:：引き続き、PAMの医療応用を拡げるために、国際会議等における波及活動と多くの共同研究の機会を得るように努める。細胞内分子機構においてはどのような分子が影響を受けるのかの知見が蓄積されてきたので、さまざまな細胞におけるさまざまな環境（プラズマ制御条件）におけるシグナリングネットワークの変化を解析することによりシステムとしての理解を目指す。これらのアプローチによりプラズマのがん細胞に対するアポトーシス誘導機構と選択的殺傷機構をより深淵かつ統括的に理解することを目指す。また殺傷と再生・増殖を制御するプラズマの条件を探索しその細胞内分子機構の解明を目指す。
③バイオ材料の表面加工技術の開発：引き続き、プラズマプロセスされたバイオ基材への生体材料の接着効果を検証する。特に原子レベルでの表面化学修飾の効果の解明に注力する。

Research Products

• [Journal Article] Copper oxide nanoparticles reduce vasculogenesis in transgenic zebrafish throufg down-regulation of VEGF expression and induction of apoptosis (2015)
  • Author(s): J. Chang, G. Ichihara, Y. Shimada, S. Tada-Oikawa, J. Kuroyanagi, B. Zhang, Y. Suzuki, R. Sehsah, M. Kato, T. Tanaka, S. Ichihara
  • Journal Title: J Nanosci Nanotechnol Volume: 15 Pages: 2140-2147
  • DOI: 10.1166/jnn.2015.9762
  • Peer Reviewed
• [Journal Article] Tumor stroma and chemokines control T cell migration into melanoma following Temozolomide treatment (2015)
  • Author(s): KW. Tan, M. Evrard, M. Tham, M. Hong, C. Huang, M. Kato, A. Prevost-Blondel, E. Donnadieu, LG. Ng, J-P. Abastado
  • Journal Title: OncoImmunology Volume: 4 Pages: e978709-1:16
  • DOI: 10.4161/2162402X.2014.978709
  • Peer Reviewed
• [Journal Article] Cigarette smoking causes hearing impairment among Bangladeshi population (2015)
  • Author(s): AF. Sumit, A. Das, Z. Sharmin, N. Ahsan, N. Ohgami, M. Kato, AA. Akhand
  • Journal Title: PLoS ONE Volume: 10 Pages: e0118960-1:12
  • DOI: 10.1371/journal.pone.0118960
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced Constitutive Invasion Activity in Human Nontumorigenic Keratinocytes Exposed to a Low Level of Barium for a Long Time (2015)
  • Author(s): ND. Thang, I. Yajima, S. Ohnuma, N. Ohgami, MY. Kumasaka, G. Ichihara, M. Kato
  • Journal Title: ENVIRONMENTAL TOXICOLOGY Volume: 30 Pages: 161-167
  • DOI: 10.1002/tox.21881
  • Peer Reviewed / Open Access
• [Journal Article] Protective effects of Phyllanthus emblica leaf extract on sodium arsenite-mediated adverse effects in mice (2015)
  • Author(s): S. Sayed, N. Ahsan, M. Kato, N. Ohgami, A. Rashid, AA. Akhand
  • Journal Title: Nagoya J Med Sci Volume: 77 Pages: 145-153
  • Peer Reviewed
• [Journal Article] 環境因子により誘発される疾患：低周波騒音による平衡機能障害 (2015)
  • Author(s): 加藤昌志
  • Journal Title: 医学のあゆみ Volume: 252 Pages: 1299-1300
  • Peer Reviewed
• [Journal Article] Quantitative clarification of inactivation mechanism of Penicillium digitatum spores treated with neutral oxygen radicals (2014)
  • Author(s): Hiroshi Hashizume, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Masaru Hori, Masafumi Ito
  • Journal Title: Jpn. J. Appl. Phys. Volume: 54 Pages: 01AG05-1:5
  • DOI: 10.7567/JJAP.54.01AG05
  • Peer Reviewed
• [Journal Article] Carbon nanowall scaffold to control culturing of cervical cancer cells (2014)
  • Author(s): Hitoshi Watanabe, Hiroki Kondo, Yukihiro Okamoto, Mineo Hiramatsu, Makoto Sekine, Yoshinobu Baba, Masaru Hori
  • Journal Title: Appl. Phys. Lett. Volume: 105 Pages: 244105-1:4
  • DOI: 10.1063/1.4902054
  • Peer Reviewed
• [Journal Article] Commentary to Krishna et al. (2014): Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water (2014)
  • Author(s): MY. Kumasaka, I. Yajima, N. Ohgami, H. Naito, Y. Omata, M. Kato
  • Journal Title: Arch Toxicol Volume: 88 Pages: 1185-1186
  • DOI: 10.1007/s00204-014-1221-y
  • Peer Reviewed
• [Journal Article] Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice (2014)
  • Author(s): M. Iida, I. Yajima, N. Ohgami, H. Tamura, K. Takeda, S. Ichihara, M. Hori, M. Kato
  • Journal Title: Eur J Dermatol Volume: 24 Pages: 392-394
  • DOI: 10.1684/ejd.2014.2330
  • Peer Reviewed
• [Journal Article] A possible role of chenodeoxycholic acid and glycine-conjugated bile acids in fibrotic steatohepatitis in a dietary rat model (2014)
  • Author(s): X. Jia, Y. Suzuki, H. Naito, H. Yetti, K. Kitamori, Y. Hayashi, R. Kaneko, M. Nomura, Y. Yamori, K. Zaitsu, M. Kato, A. Ishii, T. Nakajima
  • Journal Title: Dig Dis Sci Volume: 59 Pages: 1490-1501
  • DOI: 10.1007/s10620-014-3028-3
  • Peer Reviewed
• [Journal Article] Bidirectional functions of arsenic as a carcinogen and an anticancer agent in human squamous cell carcinoma (2014)
  • Author(s): ND. Thang, I. Yajima, M. Kumasaka, M. Kato
  • Journal Title: PLoS ONE Volume: 9 Pages: e96945-1:7
  • DOI: 10.1371/journal.pone.0096945
  • Peer Reviewed / Open Access
• [Journal Article] Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expression levels in melanocytic tumors of RET-transgenic mice (2014)
  • Author(s): I. Yajima, M. Iida, MY. Kumasaka, N. Ohgami, J. Chang, S. Ichihara, M. Hori, M. Kato
  • Journal Title: Exp Dermatol Volume: 23 Pages: 424-425
  • DOI: 10.1111/exd.12415
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells (2014)
  • Author(s): F. Vegran, H. Berger, R. Boidot, G. Mignot, M. Bruchard, M. Dosset, F. Chalmin, C. Rebe, V. Derangere, B. Ryffel, M. Kato, A. Prevost-Blondel, F. Ghiringhelli, L. Apetoh
  • Journal Title: Nature Immunology Volume: 15 Pages: 758-766
  • DOI: 10.1038/ni.2925
  • Peer Reviewed
• [Journal Article] An actin-binding protein Espin is a novel growth regulator for melanoma (2014)
  • Author(s): T. Yanagishita, I. Yajima, M. Kumasaka, M. Iida, L. Xiang, Y. Tamada, Y. Matsumoto, D. Watanabe, M. Kato
  • Journal Title: J Invest Dermatol Volume: 134 Pages: 2996-2999
  • DOI: 10.1038/jid.2014.249
  • Peer Reviewed
• [Journal Article] Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma (2014)
  • Author(s): Y. Omata, M. Iida, I. Yajima, K. Takeda, N. Ohgami, M. Hori, M. Kato
  • Journal Title: Enviorn Health Prev Med Volume: 19 Pages: 367-369
  • DOI: 10.1007/s12199-014-0399-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Commentary to Pastore et al (2014): Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors (2014)
  • Author(s): K. Takeda, Y. Kawamoto, M. Iida, Y. Omata, C. Zou, M. Kato
  • Journal Title: Arch Toxicol Volume: 88 Pages: 2319-2320
  • DOI: 10.1007/s00204-014-1373-9
  • Peer Reviewed
• [Journal Article] Melanoma-Initiating Cells Exploit M2 Macrophage TGF (2014)
  • Author(s): M. Tham, KW. Tan, J. Keeble, X. Wang, S. Hubert, L. Barron, NS. Tan, M. Kato, A. Prevost-Blondel, V. Angeli, J-P. Abastado
  • Journal Title: Oncotarget Volume: 5 Pages: 12027-12042
  • Peer Reviewed
• [Journal Article] Synergistic effect of exposure to zinc oxide nanoparticle on inflammatory response to bleomycin-induced pulmonary fibrosis in mice (2014)
  • Author(s): W. Wu, G. Ichihara, N. Hashimoto, Y. Hasegawa, Y. Hayashi, S. Tada-Oikawa, Y. Suzuki, J. Chang, M. Kato, CN. D'Alessandro-Gabazza, EC. Gabazza, S. Ichihara
  • Journal Title: Int J Mol Sci Volume: 16 Pages: 660-676
  • DOI: 10.3390/ijms16010660
  • Peer Reviewed
• [Presentation] Discharge Characteristics of Atmospheric RF Plasma Jet (2015)
  • Author(s): Giichiro Uchida, Kosuke Takenaka, Kazufumi Kawabata, Yuichi Setsuhara, Keigo Takeda, Kenji Ishikawa, Masaru Hori
  • Organizer: 7th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 8th International Conference on Plasma Nanotechnology and Science
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-30
• [Presentation] Quatitative Estimation of Inactivation of Fungal Spores Using an Atmospheric-Pressure Oxygen-Radical Source (2015)
  • Author(s): Hiroshi Hashizume, Keisuke Nishida, Takayuki Ohta, Masaru Hori, Masafumi Ito
  • Organizer: 7th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 8th International Conference on Plasma Nanotechnology and Science
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-29
• [Presentation] Growth Promotion of Saccharomyces Cerevisiae Using Periodic Oxygen-Radical Treatments (2015)
  • Author(s): Jun Kobayashi, Hiroshi Hashizume, Takayuki Ohta, Masaru Hori, Masafumi Ito
  • Organizer: 7th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 8th International Conference on Plasma Nanotechnology and Science
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-28
• [Presentation] Reactive Species Generated in Liquids Treated with Neutral Oxygen Radicals (2015)
  • Author(s): Takuya Towatari, Hiroshi Hashizume, Takayuki Ohta, Kenji Ishikawa, Masaru Hori, Masafumi Ito
  • Organizer: 7th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 8th International Conference on Plasma Nanotechnology and Science
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-28
• [Presentation] Effects of Oxygen-Radical Treatment on Cell Growth of Mouse Fibroblast Cell (2015)
  • Author(s): Yosuke Mori, Tomiyasu Murata, Masaru Hori, Masafumi Ito
  • Organizer: 7th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 8th International Conference on Plasma Nanotechnology and Science
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-28
• [Presentation] Chemical Analysis of Antitumor Effect of Plasma-Activated-Medium (2015)
  • Author(s): Naoyuki Kurake, Hiromasa Tanaka, Kenji Ishikawa, Kae Nakamura, Hiriaki Kajiyama, Fumiaki Kikkawa, Takashi Kondo, Masaaki Mizuno, Keigo Takeda, Hiroki Kondo, Makoto Sekine, Masaru Hori
  • Organizer: 7th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 8th International Conference on Plasma Nanotechnology and Science
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-28
• [Presentation] Plasma-Surface Interactions Analyzed by Vibrational Sum-Frequency Generation (SFG) (2015)
  • Author(s): Kenji Ishikawa, Keigo Takeda, Hiroki Kondo, Makoto Sekine, Masaru Hori
  • Organizer: 7th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 8th International Conference on Plasma Nanotechnology and Science
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-27
  • Invited
• [Presentation] フィールドワーク研究と実験研究の融合による紫外線発癌機構の解析と予防法の開発 (2015)
  • Author(s): 加藤昌志、矢嶋伊知朗、熊坂真由子、飯田真智子、中野千尋、大神信孝
  • Organizer: 第８５回 日本衛生学会学術総会 シンポジウム
  • Place of Presentation: 和歌山
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] Changes in Mass-Spectra of Arginine by Atmospheric Pressure Plasma Treatment (2015)
  • Author(s): Hidehiko Fujita, Takayuki Ohta, Kenji Ishikawa, Keigo Takeda, Masaru Hori
  • Organizer: 7th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 8th International Conference on Plasma Nanotechnology and Science
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-26
• [Presentation] 紫外線による総合的健康リスク評価法の開発 (2015)
  • Author(s): 中野千尋、飯田真智子、矢嶋伊知朗、熊坂真由子、小又尉広、李香、鄒存超、大神信孝、加藤昌志
  • Organizer: 第８５回 日本衛生学会学術総会和歌山
  • Place of Presentation: 和歌山
  • Year and Date: 2015-03-26
• [Presentation] モデルマウスを用いた非熱プラズマによる発癌予防効果の検討 (2015)
  • Author(s): 飯田真智子、矢嶋伊知朗、小又尉広、中野千尋、熊坂真由子、鄒存超、李香、大神信孝、加藤昌志
  • Organizer: 第８５回 日本衛生学会学術総会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-03-26
• [Presentation] Non-equilibrium atomospheric pressure plasma modulates transformation-mediated gene expression levels in melanocytic tumors in vivo (2015)
  • Author(s): Machiko IIDA, Ichiro YAJIMA, Yasuhiro OMATA, Xiang LI, Cunchao ZOU, Chihiro NAKANO, Kenji ISHIKAWA, Masaru HORI, Masashi KATO
  • Organizer: The 2nd International Workshop on Plasma for Cancer Treatment
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-16 – 2015-03-17
• [Presentation] Elucidation of plasma induced reaction mechanism for living cells using multiplex coherent anti-Stokes Raman scattering (CARS) microscopy (2015)
  • Author(s): Ryo Furuta, Takahiro Nomura, Hiroshi Hashizume, Keigo Takeda, Hiroki Kondo, Kenji Ishikawa, Takayuki Ohta, Masafumi Ito, Makoto Sekine, Masaru Hori
  • Organizer: The 2nd International Workshop on Plasma for Cancer Treatment
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-16 – 2015-03-17
• [Presentation] Effects of long-lived reactive species in the Plasma-Activated-Medium (2015)
  • Author(s): Naoyuki Kurake, Hiromasa Tanaka, Kenji Ishikawa, Kae Nakamura, Hiroaki Kajiyama, Fumitaka Kikkawa, Takashi Kondo, Masaaki Mizuno, Keigo Takeda, Hiroki Kondo, Makoto Sekine, and Masaru Hori
  • Organizer: The 2nd International Workshop on Plasma for Cancer Treatment
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-16 – 2015-03-17
• [Presentation] Application of plasma irradiation to skin tumor spontaneously developed in RET-transgenic mice (2015)
  • Author(s): Masashi KATO, Machiko IIDA, Ichiro YAJIMA, Yasuhiro OMATA, Kenji ISHIKAWA, Masaru HORI
  • Organizer: The 2nd International Workshop on Plasma for Cancer Treatment
  • Place of Presentation: Nagoya
  • Year and Date: 2015-03-16
  • Invited
• [Presentation] 酸素ラジカル照射した血清含有培地の線維芽細胞の増殖能への影響 (2015)
  • Author(s): 森 洋介、村田 富保、堀 勝、伊藤 昌文
  • Organizer: 第62回応用物理学会春季学術講演会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-03-13
• [Presentation] 定期的酸素ラジカル照射による出芽酵母細胞の増殖効果 (2015)
  • Author(s): 小林 潤、正岡 祐輝、橋爪 博司、太田 貴之、堀 勝、伊藤 昌文
  • Organizer: 第62回応用物理学会春季学術講演会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-03-13
• [Presentation] 乳腺由来細胞を用いたプラズマ照射培養液による選択的細胞死の検討 (2015)
  • Author(s): 橋爪 博司、田中 宏昌、中村 香江、吉川 史隆、石川 健治、加納 浩之、水野 正明、堀 勝
  • Organizer: 第62回応用物理学会春季学術講演会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-03-13
• [Presentation] 大気圧プラズマ活性培養液の抗腫瘍効果作用機構の解析 (2015)
  • Author(s): 倉家 尚之、田中 宏昌、石川 健治、中村 香江、梶山 広明、吉川 史隆、近藤 隆、水野 正明、竹田 圭吾、近藤 博基、関根 誠、堀 勝
  • Organizer: 第62回応用物理学会春季学術講演会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-03-13
• [Presentation] マルチプレックスコヒーレントアンチストークスラマン散乱(CARS)顕微鏡を用いたプラズマ誘起生体反応機構の解明 (2015)
  • Author(s): 古田 凌、野村 多加博、橋爪 博司、竹田 圭吾、近藤 博基、石川 健治、太田 貴之、伊藤 昌文、関根 誠、堀 勝
  • Organizer: 第62回応用物理学会春季学術講演会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-03-13
• [Presentation] AC励起大気圧Arプラズマの培養液照射中における気相活性種の計測 (2015)
  • Author(s): 梁 思潔、竹田 圭吾、熊倉 匠、近藤 博基、石川 健治、関根 誠、堀 勝
  • Organizer: 第62回応用物理学会春季学術講演会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-03-11
• [Presentation] Chemical analysis of plasma-activated medium (PAM) (2015)
  • Author(s): Kenji Ishikawa
  • Organizer: COST TD1208 2nd annual meeting - Electrical discharge with liquilds for future applications
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-02-25
  • Invited
• [Presentation] Plasma-Biological Surface Interaction for Food Hygiene (2014)
  • Author(s): Kenji Ishikawa, Hiroshi Hashizume, Takayuki Ohta, Masafumi Ito, Keigo Takeda, Hiromasa Tanaka, Hiroki Kondo, Makoto Sekine, and Masaru Hori
  • Organizer: E-MRS and MRS-J Joint Symposium, Frontier of Nano-Materials Bed on Advanced Plasma Technologies
  • Place of Presentation: Yokohama
  • Year and Date: 2014-12-11
  • Invited
• [Presentation] Development of Inactivation Technology asusing Plasma for Freshness-keeping on Post-harvest Management (2014)
  • Author(s): Takayuki Ohta, Hiroshi Hashizume, Keigo Takeda, Kenji Ishikawa, Masaru Hori, Masafumi Ito
  • Organizer: E-MRS and MRS-J Joint Symposium, Frontier of Nano-Materials Bed on Advanced Plasma Technologies
  • Place of Presentation: Yokohama
  • Year and Date: 2014-12-11
  • Invited
• [Presentation] がん治療に向けたプラズマ照射溶液の研究開発 (2014)
  • Author(s): 堀 勝、水野 正明、吉川 史隆、梶山 広明、内海 史、中村 香江、石川 健治、竹田 圭吾、田中 宏昌、加納 浩之
  • Organizer: 中部地区 医療・バイオシーズ発表会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-12-10
• [Presentation] メラニン制御によるアンチエイジング剤の開発 (2014)
  • Author(s): 加藤昌志
  • Organizer: 平成26年度バイオ系シーズ発表会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-12-10
• [Presentation] Frequency Dependence of Atmospheric-Pressure Discharge Generation (2014)
  • Author(s): Yuichi Setsuhara, Giichiro Uchida, K. Kawabata, K. Takenaka, Keigo Takeda, Kenji Ishikawa, and M. Hori
  • Organizer: 2014 Material Research Society Fall Meeting & Exhibit
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-12-04
• [Presentation] Analyses of intracellular molecular mechanisms of cancer cell death in plasma-activated solutions (2014)
  • Author(s): H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Maruyama, F. Kikkawa, M. Hori
  • Organizer: 2014 Material Research Society Fall Meeting & Exhibit
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-12-03
• [Presentation] Electron Spin Resonance Study of Plasma Activated Media (PAM) (2014)
  • Author(s): M. Hori, N. Kurake, K. Ishikawa, H. Tanaka, T. Kondo, K. Nakamura, H. Kajiyama, F. Kikkawa, M. Mizuno, K. Takeda, H. Kondo and M. Sekine
  • Organizer: 2014 Material Research Society Fall Meeting & Exhibit
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-12-03
• [Presentation] Mass-Spectral Changes of Protein Treated by Non-Equilibrium Atmospheric Pressure Plasma (2014)
  • Author(s): Takayuki Ohta, Hidehiko Fujita, Kenji Ishikawa, Keigo Takeda, and Masaru Hori
  • Organizer: 2014 Material Research Society Fall Meeting & Exhibit
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-12-03
• [Presentation] Molecular Structure of Budding Yeast Cell Measured by Multiplex Coherent Anti-Stokes Raman Scattering Microspectroscopy (2014)
  • Author(s): Takayuki Ohta, Hiroshi Hashizume, Kenji Ishikawa, Keigo Takeda, Masafumi Ito, Masaru Hori
  • Organizer: 2014 Material Research Society Fall Meeting & Exhibit
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-12-03
• [Presentation] 大気圧プラズマを用いたがん治療とその細胞内分子機構の解明 (2014)
  • Author(s): 田中 宏昌, 水野 正明, 石川 健治, 竹田 圭吾, 橋爪博司, 中村 香江, 内海 史, 梶山 広明, 加納 浩之, 岡崎 泰昌, 豊國 伸哉，丸山 彰一，小寺 泰弘, 吉川 史隆, 堀 勝
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-26
• [Presentation] Experimental study of Plasma-Liquid Interaction プラズマ照射液相の実験的解析 (2014)
  • Author(s): 石川健治
  • Organizer: PLASMA CONFERENCE 2014
  • Place of Presentation: Niigata
  • Year and Date: 2014-11-20
  • Invited
• [Presentation] Diagnostics of AC excited Atmospheric Pressure Plasma Jet with He for Biomedical Applications (2014)
  • Author(s): M. Hori, K. Takeda, T. Kumakura, K. Ishikawa, H. Tanaka, H. Kondo, M. Sekine, Y. Nakai
  • Organizer: 67th Gaseous Electronics Conference
  • Place of Presentation: Raleigh, North Carolina, USA
  • Year and Date: 2014-11-02 – 2014-11-07
• [Presentation] Multiplex coherent anti-Stokes Raman scattering microspectroscopy for monitoring molecular structural change in biological samples (2014)
  • Author(s): T. Ohta, H. Hashizume, K. Takeda, K. Ishikawa, M. Ito, M. Hori
  • Organizer: 67th Gaseous Electronics Conference
  • Place of Presentation: Raleigh, North Carolina, USA
  • Year and Date: 2014-11-02 – 2014-11-07
• [Presentation] Vacuum ultraviolet spectroscopic analysis of AC excited non-equilibrium atmospheric pressure Ar plasma jet (2014)
  • Author(s): K. Takeda, K. Ishikawa, H. Tanaka, H. Kondo, M. Sekine, M. Hori
  • Organizer: 67th Gaseous Electronics Conference
  • Place of Presentation: Raleigh, North Carolina, USA
  • Year and Date: 2014-11-02 – 2014-11-07
• [Presentation] Quantitative inactivation-mechanisms of P. digitatum and A. niger spores based on atomic oxygen dose (2014)
  • Author(s): M. Ito, H. Hashizume, T. Ohta, M. Hori
  • Organizer: 67th Gaseous Electronics Conference
  • Place of Presentation: Raleigh, North Carolina, USA
  • Year and Date: 2014-11-02 – 2014-11-07
• [Presentation] ウシ血清アルブミン(BSA)の非平衡大気圧プラズマ照射による質量分析スペクトルの変化 (2014)
  • Author(s): 藤田英彦，太田貴之，石川健治，竹田圭吾，堀勝
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 北海道
  • Year and Date: 2014-09-20
• [Presentation] 大気圧酸素ラジカル源によるコウジカビ胞子の殺菌 (2014)
  • Author(s): 森洋介，西田圭佑，橋爪博司，太田貴之，堀勝，伊藤昌文
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 北海道
  • Year and Date: 2014-09-20
• [Presentation] 酸素ラジカル照射量による出芽酵母の活性化制御 (2014)
  • Author(s): 小林潤，山内啓資，橋爪博司，太田貴之，堀勝，伊藤昌文
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 北海道
  • Year and Date: 2014-09-20
• [Presentation] 電子スピン共鳴法による中性酸素ラジカル照射溶液の解析 (2014)
  • Author(s): 唐渡卓也，橋爪博司，太田貴之，石川健治，堀勝，伊藤昌文
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 北海道
  • Year and Date: 2014-09-20
• [Presentation] 非平衡大気圧プラズマによるアルテミアの成長への影響に関する研究 (2014)
  • Author(s): 熊倉匠, 竹田圭吾, 田中宏昌, 秋山真一, 石川健治, 近藤博基, 関根誠, 堀勝
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 北海道
  • Year and Date: 2014-09-20
• [Presentation] 大気圧プラズマ照射培養液の抗腫瘍効果作用機序の解析 (2014)
  • Author(s): 倉家尚之, 田中宏昌，石川健治,中村香江,梶山広明, 吉川史隆, 近藤隆, 水野正明, 竹田圭吾, 近藤博基,関根誠, 堀勝
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 北海道
  • Year and Date: 2014-09-20
• [Presentation] プラズマ誘起バイオマテリアルの表面反応とプラズマ医療への展開 (2014)
  • Author(s): 石川健治，田中宏昌，橋爪博司，竹田圭吾，近藤博基，関根誠，堀勝
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 札幌
  • Year and Date: 2014-09-18
  • Invited
• [Presentation] Diagnostics of reactive species on bio-liquid treatment with AC power excited non-equilibrium atmospheric pressure Ar plasma (2014)
  • Author(s): Sijie Liang, Takumi Kumakura, Keigo Takeda, Hiroki Kondo, Hiroyuki Kano, Kenji Ishikawa, Makoto Sekine, Masaru Hori
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 北海道
  • Year and Date: 2014-09-17
• [Presentation] Diagnostics of AC power excited non-equilibrium atmospheric pressure plasma jet with vacuum ultraviolet spectroscopy (2014)
  • Author(s): K. Takeda, K. Ishikawa, H. Tanaka, H. Kano, Y. Higashijima, M. Sekine, M. Hori
  • Organizer: 第75回応用物理学会秋季学術講演会
  • Place of Presentation: 北海道
  • Year and Date: 2014-09-17
• [Presentation] Discharge Properties and Radical-Generation Chracteristics in DBD Plasma Jet (2014)
  • Author(s): Giichiro Uchida, Kosuke Takenaka, Kazufumi Kawabata, Atsushi Miyazaki, Yuichi Setsuhara, Keigo Takeda, Kenji Ishikawa, Masaru Hori
  • Organizer: 14th International Conference on Plasma Surface Engineering (PSE2014)
  • Place of Presentation: Germany
  • Year and Date: 2014-09-15
• [Presentation] 大気圧Ar プラズマによる細胞内外の活性酸素生成-EPR スピン捕捉法およびフローサイトメトリーによる検討- (2014)
  • Author(s): 近藤隆, 内山英史, 趙慶利, 能島信行, 竹田圭吾, 石川健治, 堀勝
  • Organizer: 第６７回日本酸化ストレス学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-04
• [Presentation] 大気圧プラズマ照射培養液の電子スピン共鳴（ESR）による解析 (2014)
  • Author(s): 石川健治, 倉家尚之, 田中宏昌, 中村香江, 近藤隆, 梶山広明, 吉川史隆, 水野正明, 竹田圭吾,近藤博基, 関根誠, 堀勝
  • Organizer: 第６７回日本酸化ストレス学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-04
• [Presentation] DAWING OF PLASMA LIFE SCIENCES ~ DIAGNOSTICS AND CONTROL OF REACTIVE SPECIES IN PLASMA BIO PROCESSING ~ (2014)
  • Author(s): M. Hori, M. Tanaka, K. Ishikawa, H. Kondo, K. Takeda, M. Sekine, F. Kikkawa, K. Nakamura, H. kajiyama and M. Mizuno
  • Organizer: The 4th International Symposium for Plasma Biosciences
  • Place of Presentation: Delpino Resort, Sokcho, Gangwon-do, Korea
  • Year and Date: 2014-08-18
  • Invited
• [Presentation] Interactions between Plasma and Biological Material: Analysis by Electron spin resonance (ESR) technique (2014)
  • Author(s): Ishikawa Kenji, Hiromasa Tanaka, Keigo Takeda, Hiroshi Hashizume, Takayuki Ohta, Masafumi Ito, Hiroki Kondo, Makoto Sekine, Masaru Hori
  • Organizer: Plasma Processing Science (Gordon Research Conference)
  • Place of Presentation: Smithfield, RI, USA
  • Year and Date: 2014-07-27 – 2014-08-01
• [Presentation] Plasma-Biological Material Interactions Studied by Employing Electron Spin Resonance (ESR) Technique (2014)
  • Author(s): Kenji Ishikawa, Hiroshi Hashizume, Takayuki Ohta, Masafumi Ito, Hiromasa Tanaka, Keigo Takeda, Satomi Tajima, Hiroki Kondo, Makoto Sekine, and Masaru Hori
  • Organizer: The XXII Europhysics Conference on Atomic and Molecular Physics of Ionized Gases (ESCAMPIG)
  • Place of Presentation: Greifswald, Germany
  • Year and Date: 2014-07-15 – 2014-07-19
• [Presentation] Inactivation of Aspergillus Niger and flavus spores using atmospheric-pressure radical source (2014)
  • Author(s): Yosuke Mori, Keisuke Nishida, Hiroshi Hashizume, Takayuki Ohta, Masaru Hori, Masafumi Ito
  • Organizer: 19th Korea-Japan Workshop on Advanced Plasma Processes and Diagnostics & 6th Workshop for NU-SKKU Joint Institute for Plasma-Nano Materials
  • Place of Presentation: Gunsan, Korea
  • Year and Date: 2014-07-06 – 2014-07-07
• [Presentation] Chemical analysis of plasma-activated-medium for understanding mechanism of its antitumor effect (2014)
  • Author(s): Naoyuki Kurake, Hiromasa Tanaka, Kenji Ishikawa, Kae Nakamura, Hiroaki Kajiyama, Fumiaki Kikkawa, Takashi Kondo, Masaaki Mizuno, Keigo Takeda, Hiroki Kondo, Makoto Sekine, and Masaru Hori
  • Organizer: 19th Korea-Japan Workshop on Advanced Plasma Processes and Diagnostics & 6th Workshop for NU-SKKU Joint Institute for Plasma-Nano Materials
  • Place of Presentation: Gunsan, Korea
  • Year and Date: 2014-07-06 – 2014-07-07
• [Presentation] Diagnostics of Non-equilibrium Atmospheric Pressure Plasma for Agricultural Application (2014)
  • Author(s): Takumi Kumakura, Keigo Takeda, Kenji Ishikawa, Hiromasa Tanaka, Hiroki Kondo, Hiroyuki Kano, Yoshihiro Nakai, Makoto Sekine, Masaru Hori
  • Organizer: 19th Korea-Japan Workshop on Advanced Plasma Processes and Diagnostics & 6th Workshop for NU-SKKU Joint Institute for Plasma-Nano Materials
  • Place of Presentation: Gunsan, Korea
  • Year and Date: 2014-07-06 – 2014-07-07
• [Presentation] Growth-activation of budding yeast cells using oxygen radical source (2014)
  • Author(s): Jun Kobayashi, Keisuke Yamauchi, Hiroshi Hashizume, Takayuki Ohta, Masaru Hori, Masafumi Ito
  • Organizer: 19th Korea-Japan Workshop on Advanced Plasma Processes and Diagnostics & 6th Workshop for NU-SKKU Joint Institute for Plasma-Nano Materials
  • Place of Presentation: Gunsan, Korea
  • Year and Date: 2014-07-06 – 2014-07-07
• [Presentation] Nano-Bio applications of carbon-nano materials synthesized and modified by plasma (2014)
  • Author(s): Hiroki Kondo, Mineo Hiramatsu, and Masaru Hori
  • Organizer: 19th Korea-Japan Workshop on Advanced Plasma Processes and Diagnostics & 6th Workshop for NU-SKKU Joint Institute for Plasma-Nano Materials
  • Place of Presentation: Gunsan, Korea
  • Year and Date: 2014-07-06
  • Invited
• [Presentation] 環境因子により誘発される疾患の発症機構の解明と予防法の開発 (2014)
  • Author(s): 加藤昌志
  • Organizer: 第84回 日本衛生学会学術総会 若手有志の会企画シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2014-05-25
  • Invited
• [Presentation] Electron Spin Resonance Study of Plasma-Liquid Medium Interactions (2014)
  • Author(s): Kenji Ishikawa, Naoyuki Kurake, Hiromasa Tanaka, Takashi Kondo, Kae Nakamura, Hiroaki Kajiyama, Fumitaka kikkawa, Masaaki Mizono, Keigo Takeda, Hiroki Kondo, Makoto Sekine, and Masaru Hori
  • Organizer: International Workshop on Diagnostics and Modelling for Plasma Medicine (DMPM2014)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-23
  • Invited
• [Presentation] The Effect of Neutral Species on Modification of the A549 andSaos-2 Growth and Proliferation (2014)
  • Author(s): Satomi Tajima, Hiroshi Hashizume, Masafumi Ito, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Makoto Sekine, and Masaru Hori
  • Organizer: International Workshop on Diagnostics and Modelling for Plasma Medicine (DMPM2014)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-23
  • Invited
• [Presentation] Quantitative evaluation of the inactivation process of P. digitatumspores on the basis of dose of ground-state atomic oxygen (2014)
  • Author(s): Hiroshi Hashizume, Takuya Towatari, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Masaru Hori, and Masafumi Ito
  • Organizer: International Workshop on Diagnostics and Modelling for Plasma Medicine (DMPM2014)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-23
  • Invited
• [Presentation] Electron Spin Resonance Study of Plasma-Biological Surface Interactions under Atmospheric Pressure Plasmas (2014)
  • Author(s): Kenji Ishikawa, Hiroshi Hashizume, Takayuki Ohta, Masafumi Ito, Hiromasa Tanaka, Keigo Takeda, Satomi Tajima, Hiroki Kondo, Makoto Sekine, and Masaru Hori
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-23
• [Presentation] Diagnostics of intercellular signaling systems of glioblastoma brain tumor cells treated with plasma-activated medium (2014)
  • Author(s): Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Hiroyuki Kano, Yasumasa Okazaki, Shinya Toyokuni, Shoichi Maruyama, Fumitaka Kikkawa, and Masaru Hori
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-23
• [Presentation] バリウムの発癌毒性 (2014)
  • Author(s): 飯田真智子、矢嶋伊知朗、熊坂真由子、大沼章子、神保 佳奈、田村青鳥、大神信孝、加藤昌志
  • Organizer: 第87回日本産業衛生学会
  • Place of Presentation: 岡山
  • Year and Date: 2014-05-22
• [Presentation] Inactivation of microorganism in liquid treated with neutral reactive oxygen species (2014)
  • Author(s): Takuya Towatari, Hiroshi Hashizume, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Masaru Hori, and Masafumi Ito
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-20
• [Presentation] Behaviors of atmospheric pressure discharge and its interaction with soft materials as a basis for plasma medicine (2014)
  • Author(s): Yuichi Setsuhara, Giichiro Uchida, Keisuke Takenaka, A. Miyazaki, K. Kawabata, Keigo Takeda, Kenji Ishikawa, and Masaru Hori
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-20
• [Presentation] Histological comparison of the wound healing process between non-thermal plasma homostatis and thermal coagulation hemostasis (2014)
  • Author(s): Daiki Yamagami, Masashi Ueda, Shinichiro Kamino, Keiko Watanabe, Masaru Hori, Kenji Ishikawa, Yuzuru Ikehara, Hajime Sakakita, and Shuichi Enomoto
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-20
• [Presentation] Free radical generation by cold atmospheric argon plasma in aqueous solutions. An ESR spin trapping study (2014)
  • Author(s): Hidefumi Uchiyama, Zhao Qing-Li, Nobuyuki Nojima, Keigo Takeda, Kenji Ishikawa, Masaru Hori, and Takashi Kondo
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-20
• [Presentation] Characteristics of AC excited non-equilibrium atmospheric pressure helium plasma jet for medical application (2014)
  • Author(s): Keigo Takeda, Takumi Kumakura, Kenji Ishikawa, Hiromasa Tanaka, Hiroki Kondo, Hiroyuki Kano, Yoshihiro Nakai, Makoto Sekine, and Masaru Hori
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-20
• [Presentation] Signaling circuits that are affected by plasma-activated medium in brain tumor cells (2014)
  • Author(s): Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Hiroyuki Kano, Yasumasa Okazaki, Shinya Toyokuni, Shoichi Maruyama, Fumitaka Kikkawa, and Masaru Hori
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-20
• [Presentation] Inactivation process of P. digitatum spores evaluated by dose of ground-state atomic oxygen (2014)
  • Author(s): Hiroshi Hashizume, Takuya Towatari, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Masaru Hori, and Masafumi Ito
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-19
• [Presentation] Characteristics of reactive particle production in atmospheric pressure DBD plasma jet (2014)
  • Author(s): Giichiro Uchida, Keisuke Takenaka, A. Miyazaki, K. Kawabata, Yuichi Setsuhara, Keigo Takeda, Kenji Ishikawa, and Masaru Hori
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-19
• [Presentation] Electron Spin Resonance Study of Plasma-Activated-Medium (2014)
  • Author(s): Kenji Ishikawa, Naoyuki Kurake, Hiromasa Tanaka, Takashi Kondo, Kae Nakamura, Hiroaki Kajiyama, Fumitaka Kikkawa, Masaaki Mizuno, Keigo Takeda, Hiroki Kondo, Makoto Sekine, and Masaru Hori
  • Organizer: The 5th International Conference on Plasma Medicine (ICPM5)
  • Place of Presentation: Nara
  • Year and Date: 2014-05-17
• [Presentation] Ultra high density atmospheric pressure plasma source (2014)
  • Author(s): Kenji Ishikawa, Keigo Takeda, Hiroki Kondo, Makoto Sekine, and Masaru Hori
  • Organizer: The International Symposium on Plasma-Nano Materials and Processes
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-04-03
  • Invited
• [Remarks] 名古屋大学プラズマ医療国際イノベーションセンター ホームページ
  • URL: http://plasmamed.nagoya-u.ac.jp/center/
• [Remarks] 名古屋大学大学院工学研究科堀・関根研究室 ホームページ
  • URL: http://horilab.nuee.nagoya-u.ac.jp/
• [Patent(Industrial Property Rights)] 抗腫瘍水溶液とその製造方法 (2015)
  • Inventor(s): 堀勝、倉家尚之、水野正明、吉川史隆、梶山広明、他３名
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2015-47884
  • Filing Date: 2015-03-11
• [Patent(Industrial Property Rights)] メラノーマ特異的バイオマーカー及びその利用 (2015)
  • Inventor(s): 加藤昌志、矢嶋伊知朗、武田湖州恵、後藤友二
  • Industrial Property Rights Holder: 名古屋大学、中部大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2015-58692
  • Filing Date: 2015-03-20
• [Patent(Industrial Property Rights)] プラズマ照射培養液による殺菌方法 (2015)
  • Inventor(s): 堀勝、石川健治、橋爪博司、伊藤昌文、太田貴之
  • Industrial Property Rights Holder: 名古屋大学、名城大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2015-29974
  • Filing Date: 2015-02-18
• [Patent(Industrial Property Rights)] プラズマ発生装置および抗腫瘍水溶液の製造方法 (2014)
  • Inventor(s): 堀勝、水野正明、吉川史隆、豊國伸哉、丸山彰一、田中宏昌、加納浩之
  • Industrial Property Rights Holder: 名古屋大学、NUエコ・エンジニアリング
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2014-180463
  • Filing Date: 2014-09-04
• [Patent(Industrial Property Rights)] 滲出型加齢黄斑変性治療薬とその製造方法 (2014)
  • Inventor(s): 寺崎浩子、堀勝、吉川史隆、水野正明、兼子裕規、田中宏昌
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2014-235675
  • Filing Date: 2014-11-20
• [Patent(Industrial Property Rights)] プラズマ照射点滴とその製造法 (2014)
  • Inventor(s): 水野正明, 堀勝、吉川史隆、梶山広明、加納浩之、他５名
  • Industrial Property Rights Holder: 名古屋大学、NUエコ・エンジニアリング
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2014-261364
  • Filing Date: 2014-12-24