Systematization of the mechanism by which plasma irradiation causes cell growth and tumor cell death

2016 Fiscal Year Final Research Report

• Project Area: Plasma medical innovation
• Project/Area Number: 24108007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: International University of Health and Welfare
• Principal Investigator: SHIMIZU Nobuyuki 国際医療福祉大学, 臨床医学研究センター, 教授 (70262128)
• Co-Investigator(Kenkyū-buntansha): 浜窪 隆雄 東京大学, 先端科学技術研究センター, 教授 (90198797) ; 張 京浩 東京大学, 医学部附属病院, 講師 (50302708) ; 山下 裕玄 東京大学, 医学部附属病院, 講師 (50599397)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: プラズマ医療科学 / 動物モデル / 酸化ストレス / プロテオソーム

Outline of Final Research Achievements

The application of the plasma into medical field is thought to be greatly useful, but the mechanism of plasma irradiation is still unclear. In our study, we performed cultured cell experiments and proved that hydrogen peroxide and nitrogen oxide played important roles of cell death.
The spread of the clinical applicability of plasma is expected. So, we established a mouse animal and a pig model to investigate the influence of plasma irradiation equipment, especially focusing on adhesion formation and inflammation.

Free Research Field

消化器外科