Systematization and development of clinical applications for plasma medicine based on scientific infrastructure

2016 Fiscal Year Annual Research Report

• Project Area: Plasma medical innovation
• Project/Area Number: 24108008
• Research Institution: Nagoya University
• Principal Investigator: 吉川 史隆 名古屋大学, 医学系研究科, 教授 (40224985)
• Co-Investigator(Kenkyū-buntansha): 梶山 広明 名古屋大学, 医学系研究科, 准教授 (00345886) ; 丸山 彰一 名古屋大学, 医学系研究科, 教授 (10362253) ; 水野 正明 名古屋大学, 医学部附属病院, 病院教授 (70283439) ; 豊國 伸哉 名古屋大学, 医学系研究科, 教授 (90252460)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: 大気圧非平衡プラズマ / プラズマ活性化培養液 / プラズマ活性化リンゲル液 / 癌治療 / 卵巣癌 / 脳腫瘍 / 悪性中皮腫

Outline of Annual Research Achievements

これまでの研究成果において、プラズマ活性化培養液（plasma activated medium:　PAM）が卵巣癌細胞に対し抗腫瘍効果を有し、ヒト卵巣癌腹膜播種マウスモデルへのPAMの腹腔内投与において、有意に癌性腹膜炎の発症を遅延させ、PAMの腹膜播種抑制効果が実証された。また、初代培養ヒト腹膜中皮細胞と卵巣癌細胞との共培養において、PAMは癌細胞の腹膜中皮細胞への接着を有意に抑制することを見出し播種を抑制する可能性が示唆された。この分子メカニズムとして、MAPK（Mitogen-Activated Protein Kinase）シグナルを介したMMP-9（Matrix metallopeptidase 9）の発現抑制が示唆された。一方で、培養液をヒトに投与することは現実的に難しい。よってPAMに変わる新たなプラズマ活性化溶液の開発を試みた。現在、臨床で点滴液として汎用されているリンゲル液に着目し、プラズマ活性化リンゲル液、特にプラズマ活性化乳酸リンゲル（plasma activated ringer’s lactate:　PAL）の効果について検討を行った。PALは脳腫瘍細胞株や卵巣癌細胞株に対し抗腫瘍効果を示した。また酢酸リンゲル液においても同様の抗腫瘍効果が認められた。さらにマウス皮下腫瘍モデルへのPALの局所投与は腫瘍形成能を有意に抑制した。その効果は、4種類からなる乳酸リンゲル液の成分の一つである乳酸ナトリウムにプラズマ照射した場合にのみ得られることが明らかとなった。
これまで、中皮腫細胞を用い、プラズマの抗腫瘍効果に影響する因子として、鉄を見出している。更なる研究の結果、還元性を示す物質であるアスコルビン酸がプラズマ感受性を強める作用があることを明らかにし、プラズマ癌治療に対し、有効な改良法となる可能性が示唆された。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Clinical significance and predicting indicators of post-cancer-treatment survival in terminally ill patients with ovarian cancer. (2017)
  • Author(s): Utsumi F, Kajiyama H, Niimi K, Sekiya R, Sakata J, Suzuki S, Shibata K, Mizuno M, Kikkawa F.
  • Journal Title: J Obstet Gynaecol Res. Volume: 43 Pages: 365-370
  • DOI: 10.1111/jog.13219.
  • Peer Reviewed
• [Journal Article] c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling. (2017)
  • Author(s): Sekiya Y, Yamamoto E, Niimi K, Nishino K, Nakamura K, Kotani T, Kajiyama H, Shibata K, Kikkawa F.
  • Journal Title: Oncology. Volume: 92 Pages: 299-310
  • DOI: 10.1159/000458529.
  • Peer Reviewed
• [Journal Article] Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer. (2017)
  • Author(s): Yokoi A, Yoshioka Y, Yamamoto Y, Ishikawa M, Ikeda SI, Kato T, Kiyono T, Takeshita F, Kajiyama H, Kikkawa F,
  • Journal Title: Nat Commun. Volume: 6 Pages: 14470
  • DOI: 10.1038/ncomms14470.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Medical applications of non-thermal atmospheric pressure plasma. (2017)
  • Author(s): H. Tanaka, M. Hori
  • Journal Title: J Clin Biochem Nutr. Volume: 60 Pages: 29-32
  • DOI: 10.3164/jcbn.16-67.
  • Peer Reviewed
• [Journal Article] Future perspective of strategic non-thermal plasma therapy for cancer treatment. (2017)
  • Author(s): H. Kajiyama, F. Utsumi, K. Nakamura, H. Tanaka, S. Toyokuni, M. Hori, F. Kikkawa
  • Journal Title: J Clin Biochem Nutr. Volume: 60 Pages: 33-38
  • DOI: 10.3164/jcbn.16-65.
  • Peer Reviewed
• [Journal Article] Intraperitoneal Administration of Plasma-Activated Medium: Proposal of a Novel Treatment Option for Peritoneal Metastasis From Gastric Cancer (2017)
  • Author(s): S. Takeda, S. Yamada, N. Hattori, K. Nakamura, H. Tanaka, H. Kajiyama, M. Kanda, D. Kobayashi, C. Tanaka, T. Fujii, M. Fujiwara, M. Mizuno, M. Hori, Y. Kodera
  • Journal Title: Annals of surgical oncology Volume: 24 Pages: 1188-1194
  • DOI: 10.1245/s10434-016-5759-1.
  • Peer Reviewed
• [Journal Article] Non-thermal atmospheric pressure plasma activates lactate in Ringer's solution for anti-tumor effects (2017)
  • Author(s): H. Tanaka, K. Nakamura, M. Mizuno, K. Ishikawa, K. Takeda, H. Kajiyama, F. Utsumi, F. Kikkawa, M. Hori,
  • Journal Title: Sci Rep Volume: 6 Pages: 36282
  • DOI: 10.1038/srep36282.
  • Peer Reviewed / Open Access
• [Journal Article] Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor (2017)
  • Author(s): Y. Shikata Y, T. Yoshimaru, M. Komatsu, H. Katoh, R. Sato, S. Kanagaki, Y. Okazaki, S. Toyokuni, E. Tashiro, S. Ishikawa, T. Katagiri, M. Imoto,
  • Journal Title: Cancer Science Volume: 108 Pages: 785-794
  • DOI: 10.1111/cas.13175.
  • Peer Reviewed / Open Access
• [Journal Article] Future perspective of strategic non-thermal plasma therapy for cancer treatment (2017)
  • Author(s): H. Kajiyama, F. Utsumi, K. Nakamura, H. Tanaka, S. Toyokuni, M. Hori, F. Kikkawa
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 60 Pages: 33-38
  • DOI: 10.3164
  • Peer Reviewed
• [Journal Article] Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma (2017)
  • Author(s): S.H. Chew, Y. Okazaki, S. Akatsuka, S. Wang, L. Jiang, Y. Ohara, F. Ito, H. Saya, Y. Sekido, S. Toyokuni
  • Journal Title: Free Radical Biology & Medicine Volume: 106 Pages: 91-99
  • DOI: 10.1016
  • Peer Reviewed
• [Journal Article] Astaxanthin ameliorates ferric nitrilotriacetate-induced renal oxidative injury in rats (2017)
  • Author(s): Y. Okazaki Y, S. Okada S, S Toyokuni
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: - Pages: -
  • Peer Reviewed
• [Journal Article] がんと微量金属元素 (Cancer and trace metal element) (2017)
  • Author(s): 伊藤文哉、豊國伸哉
  • Journal Title: 臨床検査Journal of clinical laboratory medicine Volume: 61 Pages: 216(168-173)
• [Journal Article] Cell survival of glioblastoma grown in medium containing hydrogen peroxide and/or nitrite, or in plasma-activated medium. (2016)
  • Author(s): Kurake N, Tanaka H, Ishikawa K, Kondo T, Sekine M, Nakamura K, Kajiyama H, Kikkawa F, Mizuno M, Hori M.
  • Journal Title: Arch Biochem Biophys. Volume: 605 Pages: 102-108
  • DOI: 10.1016/j.abb.2016.01.011.
  • Peer Reviewed
• [Journal Article] Radiotherapy for persistent malignant transformation from mature cystic teratoma of the ovary. (2016)
  • Author(s): Yoshida K,Kajiyama H, Utsumi F, Mitsui H, Shibata K, Kikkawa F.
  • Journal Title: J Obstet Gynaecol Res. Volume: 605 Pages: 584-588
  • DOI: 10.1111/jog.12936.
  • Peer Reviewed
• [Journal Article] PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells. (2016)
  • Author(s): Yoshikawa N, Kajiyama H, Nakamura K, Utsumi F, Niimi K, Mitsui H, Sekiya R, Suzuki S, Shibata K, Callen D,
  • Journal Title: Oncol Rep. Volume: 35 Pages: 2543-52
  • DOI: 10.3892/or.2016.4653.
  • Peer Reviewed
• [Journal Article] Comparison of prognoses according to non-positive and positive spectrin αII expression detected (2016)
  • Author(s): Maeda O, Miyata-Takata T, Shibata K, Kajiyama H, Mizuno M, Tamakoshi K, Shimoyama Y, Nakamura S, Kikkawa
  • Journal Title: Cancer Med Volume: ５ Pages: 1081-1092
  • DOI: 10.1002/cam4.683.
  • Peer Reviewed
• [Journal Article] Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single-institution experience. (2016)
  • Author(s): Tamauchi S, Kajiyama H, Sakata J, Sekiya R, Suzuki S, Mizuno M, Utsumi F, Niimi K, Kotani T, Shibata K, Kikkawa
  • Journal Title: J Obstet Gynaecol Res. Volume: 42 Pages: 1796-1801
  • DOI: 10.1111/jog.13100.
  • Peer Reviewed
• [Journal Article] Feasibility and benefit of concurrent chemoradiotherapy for elderly patients with uterine cervical cancer. (2016)
  • Author(s): Nosaka K, Shibata K, Utsumi F, Yoshida K, Niimi K, Sekiya R, Suzuki S, Kajiyama H, Kikkawa F.
  • Journal Title: Tumori Volume: 102 Pages: 600-605
  • DOI: 10.5301/tj.5000530.
  • Peer Reviewed
• [Journal Article] Efficacy of glypican-3-derived peptide vaccine therapy on the survival of patients with refractory ovarian clear cell carcinoma. (2016)
  • Author(s): Suzuki S, Sakata J, Utsumi F, Sekiya R, Kajiyama H, Shibata K, Kikkawa F, Nakatsura T.
  • Journal Title: Oncoimmunology Volume: 5 Pages: e1238542
  • DOI: 10.1080/2162402X.2016.1238542.
  • Peer Reviewed
• [Journal Article] Clinical characteristics of primary peritoneal carcinoma patients: a single-institution experience involving 8 (2016)
  • Author(s): Hattori S, Kajiyama H, Fuji U, Furui Y, Ishibashi Y, Hattori Y, Takahashi N, Kikkawa F, Misawa T.
  • Journal Title: Nagoya J Med Sci. Volume: 78 Pages: 407-414
  • DOI: 10.18999/nagjms.78.4.407.
  • Peer Reviewed
• [Journal Article] Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells. (2016)
  • Author(s): Koya Y, Kajiyama H, Liu W, Shibata K, Senga T, Kikkawa F.
  • Journal Title: J Vis Exp. Volume: 118 Pages: -
  • DOI: 10.3791/54353.
  • Peer Reviewed
• [Journal Article] Non-thermal plasma prevents progression of endometriosis in mice. (2016)
  • Author(s): C. Ishida, M. Mori, K. Nakamura, H. Tanaka, M. Mizuno, M. Hori, A. Iwase, F. Kikkawa, S. Toyokuni
  • Journal Title: Free Radical Res. Volume: 50 Pages: 1131-1139
  • Peer Reviewed
• [Journal Article] Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium (2016)
  • Author(s): F. Utsumi, H. Kajiyama, K. Nakamura, H. Tanaka, M. Mizuno, S. Toyokuni, M. Hori, F. Kikkawa
  • Journal Title: Oncology reports Volume: 35 Pages: 3169-3177
  • DOI: 10.3892/or.2016.4726.
  • Peer Reviewed
• [Journal Article] Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant (2016)
  • Author(s): L. Shi, Y. Wang, F. Ito, Y. Okazaki, H. Tanaka, M. Mizuno, M. Hori, D.R. Richardson, S. Toyokuni
  • Journal Title: Archives of biochemistry and biophysics Volume: 605 Pages: 109-116
  • DOI: 10.1016/j.abb.2016.05.016.
  • Peer Reviewed
• [Journal Article] Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis (2016)
  • Author(s): Y. Wang, Y. Okazaki, L. Shi, H. Kohda, M. Tanaka, K. Taki, T. Nishioka, T. Hirayama, H. Nagasawa, Y. Yamashita, S.
  • Journal Title: Cancer Science Volume: 107 Pages: 250-257
  • DOI: 10.1111/cas.12865
  • Peer Reviewed / Open Access
• [Journal Article] Oxidative stress as an iceberg in carcinogenesis and cancer biology (2016)
  • Author(s): S. Toyokuni
  • Journal Title: Archives of Biochemitry and Biophysics Volume: 595 Pages: 46-49
  • DOI: 10.1016/j.abb.2015.11.025
  • Peer Reviewed
• [Journal Article] The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy (2016)
  • Author(s): S. Toyokuni
  • Journal Title: Pathology Internationa Volume: 66 Pages: 245-259
  • DOI: 10.1111/pin.12396
  • Peer Reviewed / Open Access
• [Journal Article] Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics (2016)
  • Author(s): D.S. Kalinowski, C. Stefani, S. Toyokuni, T. Ganz, G.I. Anderson, N.V. Subramaniam, D. Trinder, J.K. Olynyk, A. Chua, P.J. Jansson, S. Sahni, D.J. Lane, A.M. Merlot, Z. Kovacevic, M.L. Huang, C.S. Lee, D.R. Richardson
  • Journal Title: Biochimica et Biophysica Acta Volume: 1863 Pages: 727-748
  • DOI: 10.1016/j.bbamcr.2016.01.026
  • Peer Reviewed
• [Journal Article] Pain-reducing anesthesia prevents oxidative stress in human term placenta (2016)
  • Author(s): Y. Tsuzuki, Y, Yamashita, Y. Hattori, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S,
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 58 Pages: 156-160
  • DOI: 10.3164/jcbn.15-138
  • Peer Reviewed
• [Journal Article] Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium (2016)
  • Author(s): F. Utsumi, H. Kajiyama, K. Nakamura, H. Tanaka, M. Mizuno, S. Toyokuni, M. Hori, F. Kikkawa F
  • Journal Title: Oncology Report Volume: 35 Pages: 3169-3177
  • DOI: 10.3892/or.2016.4726
  • Peer Reviewed
• [Journal Article] Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis (2016)
  • Author(s): L. Jiang, S.H. Chew, K. Nakamura, Y. Ohara, S. Akatsuka, S. Toyokuni
  • Journal Title: Cancer Sci Volume: 107 Pages: 908-915
  • DOI: 10.1111/cas.12947
  • Peer Reviewed / Open Access
• [Journal Article] Biphasic effects of L-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells (2016)
  • Author(s): L. Shi, Y. Wang, F. Ito, Y. Okazaki, H. Tanaka, M. Mizuno, M. Hori, D.R. Richardson, S. Toyokuni
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 605 Pages: 109-116
  • DOI: 10.1016/j.abb.2016.05.016
  • Peer Reviewed
• [Journal Article] Low-temperature plasma in biology and medicine (2016)
  • Author(s): M. Hori, E.H. Choi, S. Toyokuni
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 605 Pages: 1-2
  • DOI: 10.1016/j.abb.2016.06.014
  • Peer Reviewed
• [Journal Article] Antenatal saireito (TJ-114) can improve pulmonary hypoplasia and pulmonary vascular remodeling in nitrofen-induced congenital diaphragmatic hernia (2016)
  • Author(s): S. Hirako, H. Tsuda, T. Kotani, S. Sumigama, Y. Mano, T. Nakano, K. Imai, H. Li H, S. Toyokuni, F. Kikkawa
  • Journal Title: Phytotherapy Research Volume: 30 Pages: 1474-1480
  • DOI: 10.1002/ptr.5645
  • Peer Reviewed
• [Journal Article] Contrasting intra- and extra-cellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis. (2016)
  • Author(s): F. Ito, T. Nishiyama, L. Shi, M. Mori, T. Hirayama, H. Nagasawa, H. Yasui, S. Toyokuni
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 476 Pages: 600-606
  • DOI: 10.1016/j.bbrc.2016.06.003
  • Peer Reviewed
• [Journal Article] Non-thermal plasma prevents progression of endometriosis in mice (2016)
  • Author(s): Ishida M. Mori, K. Nakamura, H. Tanaka, M. Mizuno, M. Hori, A. Iwase, F. Kikkawa, S. Toyokuni
  • Journal Title: Free Radical Research Volume: 50 Pages: 1131-1139
  • DOI: 10.1080/10715762.2016.1211273
  • Peer Reviewed
• [Journal Article] Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450 (2016)
  • Author(s): C. Zong, C.E. Garner, C. Huang, X. Zhang, L. Zhang, J. Chang, S. Toyokuni, H. Ito, M. Kato, T. Sakurai, S. Ichihara, G. Ichihara
  • Journal Title: Toxicological Letters Volume: 258 Pages: 249-258
  • DOI: 10.1016/j.toxlet.2016.07.006
  • Peer Reviewed
• [Journal Article] The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology (2016)
  • Author(s): M.A. Cahill, J.A. Jazayeri, S.M. Catalano, S. Toyokuni, Z. Kovacevic, D.R. Richardson
  • Journal Title: Biochimica et Biophysica Acta Volume: 1866 Pages: 339-349
  • DOI: 10.1016/j.bbcan.2016.07.004
  • Peer Reviewed
• [Journal Article] Molecular hydrogen suppresses activated Wnt-catenin signaling. (2016)
  • Author(s): Y. Lin, B. Ohkawara, M. Ito, N. Misawa, K. Miyamoto, Y. Takegami, A. Masuda, S. Toyokuni, K Ohno
  • Journal Title: Scientific Report Volume: 25 Pages: 31986
  • DOI: 10.1038/srep31986
  • Peer Reviewed / Open Access
• [Journal Article] Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma (2016)
  • Author(s): S. Wang, L. Jiang, Y. Han, S.H. Chew, Y. Ohara, S. Akatsuka, L. Weng, K. Kawaguchi, T. Fukui, Y. Sekido, K. Yokoi, S. Toyokuni
  • Journal Title: Oncotarget Volume: 7 Pages: 69565-69578
  • DOI: 10.18632/oncotarget.11829
  • Peer Reviewed / Open Access
• [Journal Article] Editorial: The cutting edge of zinc biology (2016)
  • Author(s): T. Kambe, T. Fukada, S. Toyokuni
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 611 Pages: 1-2
  • DOI: 10.1016/j.abb.2016.09.006
  • Peer Reviewed
• [Journal Article] Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells. (2016)
  • Author(s): Y.P. Han, A. Enomoto, Y. Shiraki, S.Q. Wang, X. Wang, S. Toyokuni, N. Asai, K. Ushida, H. Ara, F. Ohka, T. Wakabayashi, J. Ma, A. Natsume, M. Takahashi
  • Journal Title: Neurological Oncology Volume: now237 Pages: 1-12
  • DOI: 10.1093
  • Peer Reviewed
• [Presentation] Chemical reaction mechanism in non-thermal plasma from the viewpoint of oxidative stress toward biological appications. (2017)
  • Author(s): Toyokuni S
  • Organizer: Mini-Ssymposium of the Archives of Biocheistry and Biophycs Editors As part of the HBKU Life Science Seminar Series
  • Place of Presentation: Education City Liberal Arts & Science Building, Lecture Hall C; （Doha, Qater）
  • Year and Date: 2017-03-23 – 2017-03-23
  • Int'l Joint Research / Invited
• [Presentation] Biological and pathological significance of free radicals and oxidative stress. (2017)
  • Author(s): Toyokuni S
  • Organizer: One Day School on Radiation and Redox Process in Health
  • Place of Presentation: Multipurpose Hall, Training School Hostel, Bhabha Atomic Research Institute（Mumbai, India）
  • Year and Date: 2017-01-09 – 2017-01-12
  • Int'l Joint Research / Invited
• [Presentation] Plenary Lecture: Chemical reaction mechanism in non-thermal plasma from the viewpoint of oxidative stress toward biological applications. (2017)
  • Author(s): Toyokuni S
  • Organizer: XVth Annual Meeting of SFRR-India 2017
  • Place of Presentation: Multipurpose Hall, Training School Hostel, Bhabha Atomic Research Institute（Mumbai, India）
  • Year and Date: 2017-01-09 – 2017-01-12
  • Int'l Joint Research
• [Presentation] Prognostic factors of fertility sparing surgery for ovarian clear cell carcinoma in women of reproductive age (2016)
  • Author(s): Masato Yoshihara, Hiroaki Kajiyama, Kiyosumi Shibata, Fumitaka Kikkawa
  • Organizer: 1st congress of fertility preservation, Asian Society of Fertility Preservation
  • Place of Presentation: Equatorial Hotel（Ho Chi Minh City, Vietnam）
  • Year and Date: 2016-11-19 – 2016-11-19
• [Presentation] Clinical outcome and prognostic factors of patients with recurrent uterine cervical cancer (2016)
  • Author(s): 吉田康将、梶山広明、内海史、坂田純、 新美薫、関谷龍一郎、鈴木史朗、柴田清住、吉川史隆
  • Organizer: 16th Biennial Meeting of the Interanational Gynecologic Cancer Society (IGCS)
  • Place of Presentation: Centro de Congressos de liaboa（Lisbon,Portugal）
  • Year and Date: 2016-10-29 – 2016-10-31
  • Int'l Joint Research
• [Presentation] Prognostic factors for patients with clear cell adenocarcinoma of the ovary at reproductive age (2016)
  • Author(s): Masato Yoshihara, Hiroaki Kajiyama, Satoshi Tamauchi,Kayo Fujikake, Atsushi Sekiya, Ryuichiro Sekiya, Shiro Suzuki, Kiyosumi Sibata, Kikkawa Fumitaka
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-22 – 2016-10-22
• [Presentation] Role of iron in carcinogenesis. (2016)
  • Author(s): Toyokuni S
  • Organizer: International Symposium on Redox Biology and Mitochondrial Medicine & 2016 Cross-Strait Free Radical
  • Place of Presentation: Mackay Medical College（New Taipei City, Taiwan）
  • Year and Date: 2016-10-21 – 2016-10-22
  • Int'l Joint Research / Invited
• [Presentation] 遠隔転移を認める子宮頸癌に対する治療法の後方視的検討 (2016)
  • Author(s): 吉田康将、内海史、新美薫、関谷龍一郎、鈴木史朗、梶山広明、柴田清住、吉川史隆
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-20 – 2016-10-22
• [Presentation] Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and promotes formation of tumor microenvironment with mesothelial cells in epithelial ovarian cancer (2016)
  • Author(s): Masato Yoshihara, Hiroaki Kajiyama, Kousuke Yoshida, Akiko Shinbo, Jun Sakata, Kiyosumi Shibara, Fumitaka Kikkawa
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-08 – 2016-10-08
• [Presentation] 表層上皮性卵巣癌におけるパクリタキセル耐性能と腹膜中皮細胞との微小環境形成 (2016)
  • Author(s): 吉原雅人、梶山広明、吉田康将、新保暁子、坂田 純、柴田清住、吉川史隆
  • Organizer: 第６回生理学研究所・名古屋大学医学系研究科合同シンポジウム
  • Place of Presentation: 名古屋大学（愛知県名古屋市）
  • Year and Date: 2016-09-24 – 2016-09-24
• [Presentation] Plenary lecture 1: Insights into chemical reaction mechanism in plasma medicine from the viewpoint of oxidative stress. (2016)
  • Author(s): Toyokuni S
  • Organizer: 6th International Conference on Plasma Medicine
  • Place of Presentation: Comenius University et.（Bratislava, Slovakia）
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] 表層上皮性卵巣癌における化学療法耐性能と腹膜中皮細胞との微小環境形成 (2016)
  • Author(s): 吉原雅人、梶山広明、新保暁子、坂田純、柴田清住、吉川史隆
  • Organizer: 第15回日本婦人科がん分子標的研究会
  • Place of Presentation: ニューオータニイン札幌（北海道札幌市）
  • Year and Date: 2016-08-19 – 2016-08-19
• [Presentation] 表層上皮性卵巣癌における化学療法耐性能が及ぼす腹膜播種形成への影響 (2016)
  • Author(s): 吉原雅人、梶山広明、吉田康将、新保暁子、坂田 純、柴田清住、吉川史隆
  • Organizer: 第21回日本病態プロテアーゼ学会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府大阪市）
  • Year and Date: 2016-08-05 – 2016-08-05
• [Presentation] 卵巣明細胞腺癌に対するGPC3を標的としたペプチドワクチン療法 ～臨床第Ⅱ相試験のデータ解析から見える今後の課題～ (2016)
  • Author(s): 鈴木 史朗, 柴田 清住, 吉川 史隆, 中面 哲也
  • Organizer: 第20回日本がん免疫学会総会
  • Place of Presentation: 大阪国際交流センター（大阪府大阪市）
  • Year and Date: 2016-07-27 – 2016-07-29
• [Presentation] 卵巣癌における新規腫瘍抗原KIF20A発現の検討とペプチドカクテルワクチン療法への臨床応用 (2016)
  • Author(s): 河合要介, 鈴木史朗, 梶山広明, 柴田清住, 吉川史隆
  • Organizer: 第20回日本がん免疫学会総会
  • Place of Presentation: 大阪国際交流センター（大阪府大阪市）
  • Year and Date: 2016-07-27 – 2016-07-29
• [Presentation] 当院において再発卵巣がんに対してノギテカン療法を行った23例の検討 (2016)
  • Author(s): 吉田康将、内海史、新美薫、関谷龍一郎、鈴木史朗、梶山広明、柴田清住、吉川史隆
  • Organizer: 第58回婦人科腫瘍学会学術講演会
  • Place of Presentation: 米子コンベンションセンター（鳥取県米子市）
  • Year and Date: 2016-07-08 – 2016-07-10
• [Presentation] what we have learned from animal studies toward its prevention. (2016)
  • Author(s): Toyokuni S
  • Organizer: The 9th International Conference on the Biology, Chemistry, and the Therapeutic Applications of Nitric Oxide.
  • Place of Presentation: Sendai Interntional Center（宮城県仙台市）
  • Year and Date: 2016-05-20 – 2016-05-22
  • Int'l Joint Research / Invited
• [Presentation] Oxidants and antioxidants in biology; Redox medicine and nutrition. (2016)
  • Author(s): Toyokuni S
  • Organizer: Oxygen Club of California 2016
  • Place of Presentation: University of California Davis（Davis, CA, USA）
  • Year and Date: 2016-05-04 – 2016-05-06
  • Int'l Joint Research / Invited
• [Presentation] Post recurrence oncologic outcome of patients with uterine cervical cancer (2016)
  • Author(s): 吉田康将、梶山広明、内海史、新美薫、関谷龍一郎、鈴木史朗、柴田清住、吉川史隆
  • Organizer: 第68回日本産婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-04-22 – 2016-04-22
• [Presentation] Current aspects on oxidative stress and aging. (2016)
  • Author(s): Toyokuni S
  • Organizer: SFB974 Mini-Workshop
  • Place of Presentation: Leber- und Infektionszentrum, Henrich Heine Universitaet Duesseldorf（Duesseldorf, Germany）
  • Year and Date: 2016-04-15 – 2016-04-15
  • Int'l Joint Research / Invited
• [Patent(Industrial Property Rights)] 成長促進水溶液…農作物および魚類の生産方法 (2016)
  • Inventor(s): 堀勝、水野正明、橋爪博司、田中宏昌、石川健治、秋山真一、他
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-221212
  • Filing Date: 2016-11-08