Creation of kinetics and establishment of safety medical science on plasma nano material

2016 Fiscal Year Annual Research Report

• Project Area: Plasma medical innovation
• Project/Area Number: 24108009
• Research Institution: Kyushu University
• Principal Investigator: 田中 昭代 九州大学, 医学研究院, 講師 (10136484)
• Co-Investigator(Kenkyū-buntansha): 米須 章 琉球大学, 工学部, 教授 (90220764) ; 古閑 一憲 九州大学, システム情報科学研究院, 准教授 (90315127) ; 柳生 義人 佐世保工業高等専門学校, 電気電子工学科, 准教授 (40435483) ; 北崎 訓 福岡工業大学, 工学部, 助教 (70713147) ; 山下 佳雄 佐賀大学, 医学部, 教授 (50322300)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: プラズマ / ナノマテリアル / 健康影響評価 / 体内動態 / 医療科学 / プラズマ照射水

Outline of Annual Research Achievements

本年は大気圧低温プラズマの安全性評価として①極細大気圧プラズマ装置を用いたマウス皮膚への影響評価、②プラズマ活性培養液（Plasma-activated medium: PAM)の腹腔内投与による健康影響評価を行った。
①極細大気圧プラズマ装置を用いたマウス皮膚への影響評価
8週齢のヘアレスマウスを用いた。プラズマ源として極細大気圧プラズマ源を用いて、ヘアレスマウス背部皮膚へ20秒間にわたって電極とヘアレスマウス皮膚間距離は20ｍｍ、30ｍｍ、40ｍｍ、50ｍｍ(4箇所/マウス)でプラズマ照射を行った。照射直後から7日目までの背部皮膚組織の経時的な病理組織学的評価を行った。さらに、画像ソフトを用いた皮膚色度変化量より照射効果を定量した。今回の結果より、プラズマ20秒照射の場合、皮膚間距離がプラズマ源より30ｍｍ以下の場合には皮膚障害が発現する可能性があるが、少なくともプラズマ源から40ｍｍ以上の距離では皮膚障害の可能性は低いことが示唆された。さらに、皮膚障害の評価法において、色度変化量と皮膚組織の病変の程度は対応し、色度を用いることで簡易にプラズマ照射効果を定量できる可能性が示唆された。
②PAMの腹腔内投与による健康影響評価
実験群は4群（PAM群、Medium群、Cisplatin群、NaCl群）に分け、Cisplatin群を除いた3群では各試料1ml/匹をマウスの腹腔内に2週間連続投与を行った。Cisplatin群ではCisplatin　0.4ml/匹を腹腔内に週1回、2週間で2回投与した。投与開始より15日目にマウスの各臓器の組織障害性について光顕、透過型電子顕微鏡（TEM）を用いて評価した。
マウスを用いたPAMの連続２週間腹腔内投与（1ml/匹）ではCisplatinに比べて明確な組織障害は認められず、PAMによる副作用の発現は非常に少ないと考えられた。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Kiel University(Germany)
  • Country Name: Germany
  • Counterpart Institution: Kiel University
• [Int'l Joint Research] Sungkyunkwan University(韓国)
  • Country Name: KOREA (REP. OF KOREA)
  • Counterpart Institution: Sungkyunkwan University
• [Journal Article] Personal indium exposure concentration in respirable dusts and serum indium level (2017)
  • Author(s): S. Iwasawa, M. Nakano, H. Miyauchi, S. Tanaka, Y. Kawasumi, I. Higashikubo, A.Tanaka, M. Hirata, K. Omae
  • Journal Title: Ind. Health Volume: 55 Pages: 87-90
  • DOI: 10.2486/indhealth.2016-0015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nitrogen gas plasma treatment of bacterial spores induces oxidative stress that damages the genomic DNA (2017)
  • Author(s): A. Sakudo, Y. Toyokawa, T. Nakamura, Y. Yagyu, Y. Imanishi
  • Journal Title: Mol. Med. Rep. Volume: 15 Pages: 396-402
  • DOI: 10.3892/mmr.2016.5973
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Response of Silkworm Larvae to Atmospheric Pressure Non-thermal Plasma Irradiation (2017)
  • Author(s): T. Sarinont, Y. Wada, K. Koga, M. Shiratani,
  • Journal Title: Plasma Medicine, Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1615/PlasmaMed.2017019137
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Plant Growth Enhancement of Seeds Immersed in Plasma Activated Water, (2017)
  • Author(s): T. Sarinont, R. Katayama, Y. Wada, K. Koga, M. Shiratani
  • Journal Title: MRS Advances Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1557/adv.2017.178
  • Acknowledgement Compliant
• [Journal Article] Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway (2017)
  • Author(s): I. Egashira , F. Takahashi-Yanaga, R. Nishida, M. Arioka, K. Igawa, K. Tomooka, Y. Nakatsu, T. Tsuzuki, Y. Nakabeppu, T. Kitazono, T. Sasaguri
  • Journal Title: Cancer Sci Volume: 108 Pages: 108-115
  • DOI: 10.1111/cas.13106
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ガスプラズマを用いた農産物・食品の低温ドライ殺菌技術 (2017)
  • Author(s): 柳生義人
  • Journal Title: ふーま Volume: 33 Pages: 24-27
  • Acknowledgement Compliant
• [Journal Article] プラズマによる低温・ドライ殺菌技術の研究開発 (2017)
  • Author(s): 柳生義人
  • Journal Title: 食品と開発 Volume: 52 Pages: 68-70
  • Acknowledgement Compliant
• [Journal Article] An advanced case of indium lung disease with progressive emphysema (2016)
  • Author(s): M. Nakano, A. Tanaka, M. Hirata, H. Kumazoe, K. Wakamatsu, D. Kamada, K. Omae
  • Journal Title: J. Occup Health Volume: 58 Pages: 477-481
  • DOI: 10.1539/joh.16-0076-CS
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A new roller conveyer system of non-thermal gas plasma as a potential control measure of plant pathogenic bacteria in primary food production (2016)
  • Author(s): Y. Toyokawa, Y. Yagyu, T. Misawa, A. Sakudo
  • Journal Title: Food Control Volume: 72 Pages: 62-72
  • DOI: 10.1016/j.foodcont.2016.07.031
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of irradiation distance on supply of reactive oxygen species to the bottom of a Petri dish filled with liquid by an atmospheric O2/He plasma jet (2016)
  • Author(s): T. Kawasaki, S. Kusumegi, A. Kudo, T. Sakanoshita, T. Tsurumaru, A. Sato, G. Uchida, K. Koga, M. Shiratani
  • Journal Title: J. Appl. Phys. Volume: 119 Pages: 173301
  • DOI: 10.1063/1.4948430
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of plasma irradiation using various feeding gases on growth of Raphanus sativus L (2016)
  • Author(s): T. Sarinont, T. Amano, P. Attri, K. Koga, N. Hayashi, M. Shiratani
  • Journal Title: Arch. Biochem. Biophys. Volume: 605 Pages: 129-140
  • DOI: 10.1016/j.abb.2016.03.024
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mechanism and comparison of needle-type non-thermal direct and indirect atmospheric pressure plasma jets on the degradation of dyes (2016)
  • Author(s): P. Attri, M. Yusupov, J. H. Park, L. P. Lingamdinne, J. R. Koduru, M. Shiratani, E. Choi, A. Bogaerts
  • Journal Title: Scientific Reports Volume: 6 Pages: 34419
  • DOI: 10.1038/srep34419
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Variation in structure of proteins by adjusting reactive oxygen and nitrogen species generated from dielectric barrier discharge jet, (2016)
  • Author(s): J. H. Park, M. Kim, M. Shiratani, Art. E. Cho, E. Choi, P. Attri,
  • Journal Title: Scientific Reports Volume: 6 Pages: 35883
  • DOI: 10.1038/srep35883
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effects of nonthermal plasma jet irradiation on the selective production of H2O2 and NO2- in liquid water (2016)
  • Author(s): G. Uchida, A. Nakajima, T. Ito, K. Takenaka, T. Kawasaki, K. Koga, M. Shiratani, Y. Setsuhara
  • Journal Title: J. Appl. Phys Volume: 120 Pages: 203302
  • DOI: 10.1063/1.4968568
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] BUBR1 Insufficiency in Mice Increases their Sensitivity to Oxidative Stress (2016)
  • Author(s): D. Matsuda, T. Matsumoto, K. Honma, A. Ikawa-Yoshida, M. Onimaru, T. Furuyama, Y. Nakatsu, T. Tsuzuki, Y. Maehara
  • Journal Title: In Vivo Volume: 30 Pages: 769-776
  • DOI: 10.21873/invivo.10993
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality, (2016)
  • Author(s): A. Ikawa-Yoshida, T. Matsumoto, S. Okano, Y. Aoyagi, Y. Matsubara, T. Furuyama, Y. Nakatsu, T. Tsuzuki, M. Onimaru, T. Ohkusa, M. Nomura, Y. Maehara
  • Journal Title: Scientific Reports Volume: 6 Pages: 32399
  • DOI: 10.1038/srep32399
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Insertion and Deletion Mismatches Distant from the Target Position Improve Gene Correction with a Tailed Duplex (2016)
  • Author(s): H. Kamiya, N. Nishigaki, A. Ikeda, S. Yukawa, Y. Morita, Y. Nakatsu, T. Tsuzuki, H. Harashima
  • Journal Title: Nucleosides Nucleotides Nucleic Acids Volume: 35 Pages: 379-388
  • DOI: 10.1080/15257770.2016.1163384
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Inactivation of oral cancer cell using active species generated by atmospheric plasma (2016)
  • Author(s): R. Ono, T. Ohtsubo, N. Hayashi, R. Aijima, Y. Yamashita, M. Goto
  • Journal Title: J Photopolym Sci Technol Volume: 29 Pages: 443-445
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characteristics of surface sterilization using electron cycrotron plasma (2016)
  • Author(s): A.Yonesu, K.Hara. T.Nishikawa, N.Hayashi
  • Journal Title: Jpn.J.Apol.Phys Volume: 55 Pages: 07LG08-1-4
  • DOI: 10,7567/JJAP.55.07LG08
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Decoposition of proteins using microwave air plasma sterilizer (2016)
  • Author(s): T.Itarashiki, N.Hayashi, A.Yonesu,
  • Journal Title: Trans.Mat.Res.Soc.Japan, Volume: 41 Pages: 179-182
  • DOI: 10,14723/tmrsj.411179
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 高電圧・プラズマによる農業水産応用の基礎 (2016)
  • Author(s): 林信哉，柳生義人
  • Journal Title: 電気学会誌 Volume: 136 Pages: 798-801
  • Acknowledgement Compliant
• [Journal Article] R&D status of agricultural applications of high voltage and plasma in Japan, (2016)
  • Author(s): M. Shiratani, T. Sarinont, K. Koga, N. Hayashi,
  • Journal Title: Proc. Workshop on Application of Advanced Plasma Technologies in CE Agriculture Volume: - Pages: 29-30
  • Acknowledgement Compliant
• [Presentation] Analyses of Oxidative Mutagenesis and Carcinogenesis Using Genetically Modified Mice: Application to Plasma Medicine, (2017)
  • Author(s): Y. Nakatsu, N. Takano, M. Ohno, S. Kitazaki, K. Koga, A. Tanaka, M. Shiratani, T. Tsuzuki
  • Organizer: 4th International Workshop on Plasma for Cancer Treatment (IWPCT-2017),
  • Place of Presentation: Paris, Franc
  • Year and Date: 2017-03-27
  • Int'l Joint Research / Invited
• [Presentation] 酵母の遺伝子発現に大気圧プラズマジェット照射が与える影響 (2017)
  • Author(s): "柳生義人、本村将次、中尾吉貴、林信哉、山崎隆志、猪原武士、大島多美子、川崎仁晴
  • Organizer: 第64回応用物理学会春季学術講演会
  • Place of Presentation: 横浜市
  • Year and Date: 2017-03-14 – 2017-03-17
• [Presentation] ローラーコンベアー型プラズマ装置による農薬の分解 (2017)
  • Author(s): 豊川洋一、柳生義人、作道章一
  • Organizer: 第64回応用物理学会春季学術講演会
  • Place of Presentation: 横浜市
  • Year and Date: 2017-03-14 – 2017-03-17
• [Presentation] Long-term evaluation of In nanoparticle transport in living body (2017)
  • Author(s): K. Koga, A. Tanaka, M. Hirata, T. Amano, T. Sarinont, H. Seo, N. Itagaki, M. Shiratani
  • Organizer: ISPlasma 2017/IC-PLANTS 2017
  • Place of Presentation: Aichi, Japan
  • Year and Date: 2017-03-01 – 2017-03-05
  • Int'l Joint Research
• [Presentation] Effects of non-thermal atmospheric air plasma irradiation on mice skin (2017)
  • Author(s): Y. Nakatsu, N. Takano, M. Ohno, S. Kitazaki, K. Koga, T. Amano, A. Tanaka, M. Hirata, M. Shiratani, T. Tsuzuki,
  • Organizer: International Conference on Plasma Medical Science Innovation (ICPMSI)
  • Place of Presentation: Nagoya, Japan,
  • Year and Date: 2017-02-28
  • Int'l Joint Research / Invited
• [Presentation] Gene Expression Profile of Yeast, Saccharomyces cerevisiae, after Low-temperature Plasma Treatment (2017)
  • Author(s): "Y. Yagyu, M. Motomura, Y. Nakao, N. Hayashi, T. Yamasaki, T. Ohshima, T. Ihara, H. Kawasaki
  • Organizer: International Conference on Plasma Medical Science Innovation（ICPMSI2017）
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] INFLUENCE OF ATMOSPHERIC PRESSURE PLASMA IRRADIATION ON SKIN OF HAIRLESS MICE EVALUATED USING CHROMATICITY DIAGRAM (2017)
  • Author(s): N. Goto, S. Kitazaki, A. Tanaka, M. Hirata, Y. Nakatsu, K. Koga, M. Shiratani
  • Organizer: International Conference on Plasma Medical Science Innovation (ICPMSI)
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] 大気圧プラズマを用いた口腔がん治療法開発のための基礎研究 (2017)
  • Author(s): 山下佳雄、合島怜央奈、森啓輔、鶴岡祥子、檀上敦
  • Organizer: 第35回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2017-01-27
• [Presentation] Low Temperature Air Plasma Irradiation to Rice Seeds (2017)
  • Author(s): M. Shiratani, T. Sarinont, Y. Wada, K. Koga
  • Organizer: 34th Symposium on Plasma Processing (SPP34) / The 29th Symposium on Plasma Science for Materials (SPSM29)
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2017-01-18
  • Int'l Joint Research
• [Presentation] Analyses of Oxidative Mutagenesis and Carcinogenesis Using Genetically Modified Mice: Application to Plasma Medicine (2016)
  • Author(s): Y. Nakatsu, N. Takano, M. Ohno, S. Kitazaki, K. Koga, A. Tanaka, M. Shiratani, T. Tsuzuki,
  • Organizer: 26th annual meeting of MRS-J
  • Place of Presentation: Yokohama, Japan,
  • Year and Date: 2016-12-21
  • Int'l Joint Research / Invited
• [Presentation] Effects of plasma irradiation on growth of wheat and melon (2016)
  • Author(s): T. Sarinont, Y. Wada, R. Katayama, K. Koga, M. Shiratani
  • Organizer: 26th annual meeting of MRS-J
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-12-21
• [Presentation] Stimulation of germinability of seeds under various gas plasma activated water (2016)
  • Author(s): Y. Wada, T. Sarinont, R. Katayama, K. Koga, M. Shiratani
  • Organizer: 26th annual meeting of MRS-J
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-12-21
• [Presentation] Dependence of amount of plasma activated water on growth enhancement of radish sprout (2016)
  • Author(s): K. Koga, T. Sarinont, R. Katayama, Y. Wada, H. Seo, N. Itagaki, M. Shiratani
  • Organizer: 26th annual meeting of MRS-J
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-12-21
• [Presentation] Scalable DBDによるRONS照射量の二次元分布 (2016)
  • Author(s): 大井手芳徳、片山龍、サリノント タパナット、和田陽介、徐鉉雄、板垣奈穂、古閑一憲、白谷正治
  • Organizer: プラズマ・核融合学会九州・沖縄・山口支部 第20回支部大会
  • Place of Presentation: 福岡市
  • Year and Date: 2016-12-17
• [Presentation] 大気圧DBDジェット装置のRONS照射量比較実験 (2016)
  • Author(s): 片山龍、サリノント タパナット、大井手芳徳、和田陽介、古閑一憲、山下大輔、徐鉉雄、板垣奈穂、田中昭代、白谷正治
  • Organizer: プラズマ・核融合学会九州・沖縄・山口支部 第20回支部大会
  • Place of Presentation: 福岡市
  • Year and Date: 2016-12-17
• [Presentation] 大気圧DBDプラズマによる植物収穫量の向上 (2016)
  • Author(s): サリノント タパナット、和田陽介、片山龍、古閑一憲、白谷正治
  • Organizer: プラズマ・核融合学会九州・沖縄・山口支部 第20回支部大会
  • Place of Presentation: 福岡市
  • Year and Date: 2016-12-17
• [Presentation] シロイヌナズナ種子へのプラズマ照射効果に対する前処理の影響 (2016)
  • Author(s): 和田陽介、サリノント タパナット、片山龍、古閑一憲、白谷正治
  • Organizer: プラズマ・核融合学会九州・沖縄・山口支部 第20回支部大会
  • Place of Presentation: 福岡市
  • Year and Date: 2016-12-17
• [Presentation] ヒト細胞由来ミスマッチ修復遺伝子変異体の作製とその解析 (2016)
  • Author(s): 林田元気、中津可道、日高京子、藤兼亮輔、日高真純、釣本敏樹、續輝久
  • Organizer: 日本分子生物学会第39回年会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-12-03
• [Presentation] CRISPR/Cas9 を用いたDNAポリメラーゼδ R５０６H突然変異のMSH2-null HeLa MR 細胞への導入 (2016)
  • Author(s): 宋頴霞、日高京子、中津可道、織田信弥、林田元気、藤兼亮輔、日高真純、續輝久
  • Organizer: 日本分子生物学会第39回年会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-12-03
• [Presentation] プラズマ殺菌能を有したベルトコンベア型農産物搬送装置の開発 (2016)
  • Author(s): 山口充洋、宮本大毅、柳生義人、猪原武士、大島多美子、川崎仁晴、林信哉、作道章一
  • Organizer: 平成28年度応用物理学会九州支部学術講演会
  • Place of Presentation: 対馬市
  • Year and Date: 2016-12-03
• [Presentation] 大気圧 DBDプラズマを照射した水のRONS濃度の水量依存性 (2016)
  • Author(s): 和田陽介、サリノント タパナット、片山龍、古閑一憲、白谷正治
  • Organizer: 平成28年度応用物理学会九州支部学術講演会
  • Place of Presentation: 対馬市
  • Year and Date: 2016-12-03
• [Presentation] 大気圧プラズマジェット照射による模擬生体中へのROSの供給 (2016)
  • Author(s): 黒枝剛哉、清竜平、山口真央、吉永怜史、山下莉穂、田崎光、川崎敏之、内田儀一郎、古閑一憲、白谷正治
  • Organizer: 平成28年度応用物理学会九州支部学術講演会
  • Place of Presentation: 対馬市
  • Year and Date: 2016-12-03
• [Presentation] Comparative study on death of cells irradiated by non-thermal plasma, X-ray, and UV (2016)
  • Author(s): K. Koga, T. Amano, T. Sarinont, R. Katayama, Y. Wada, H. Seo, N. Itagaki, M. Shiratani, A. Tanaka, Y. Nakatsu
  • Organizer: 平成28年度応用物理学会九州支部学術講演会
  • Place of Presentation: 対馬市
  • Year and Date: 2016-12-03
• [Presentation] Mutyh欠損マウスにおける酸化ストレスによる消化管腫瘍発生頻度上昇と特異的体細胞変異シグニチャーの解析 (2016)
  • Author(s): 鷹野典子、大野みずき、中津可道、中別府雄作、續輝久
  • Organizer: 日本分子生物学会第39回年会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-12-02
• [Presentation] Plant Growth Enhancement of Seeds Immersed in Plasma Activated Water (2016)
  • Author(s): T. Sarinont, K. Koga, M. Shiratani
  • Organizer: 2016 MRS Fall Meeting & Exhibit
  • Place of Presentation: Boston, Massachusetts
  • Year and Date: 2016-11-29
  • Int'l Joint Research
• [Presentation] ヒト口腔癌細胞株に対するプラズマの抗腫瘍効果の検討 (2016)
  • Author(s): 山下佳雄、合島怜央奈、森啓輔、鶴岡祥子、下平大治、檀上敦
  • Organizer: 第61回（公社）日本口腔外科学会総会・学術大会
  • Place of Presentation: 千葉市
  • Year and Date: 2016-11-26
• [Presentation] ヘアレスマウスへの大気圧プラズマ照射効果 (2016)
  • Author(s): 北﨑訓、田中昭代、平田美由紀、中津可道、古閑一憲、白谷正治
  • Organizer: 第32回九州・山口プラズマ研究会
  • Place of Presentation: 佐賀市
  • Year and Date: 2016-11-19 – 2016-11-20
• [Presentation] ミスマッチ修復欠損マウスを用いた新規生殖細胞変異の検出 (2016)
  • Author(s): 大野みずき、鷹野典子、佐々木史子、中津可道、續輝久
  • Organizer: 日本環境変異原学会第45回大会
  • Place of Presentation: つくば市
  • Year and Date: 2016-11-17
• [Presentation] Development of assay systems to characterize the variants of mismatch repair factor MSH2 found in Lynch syndrome (2016)
  • Author(s): G. Hayashida, Y. Nakatsu, K. Hidaka, R. Fujikane, M. Hidaka, T. Tsurimoto, T. Tsuzuki
  • Organizer: The 10th International 3R (Replication, Recombination and Repair) Symposium
  • Place of Presentation: Matsue, Japan
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Control of Plant Growth by RONS Produced Using Nonthermal Atmospheric Air Plasma (2016)
  • Author(s): K. Koga, T. Sarinont, M. Shiratani
  • Organizer: American Vacuum Society 63ｒd International Symposium and Exhibition (AVS63)
  • Place of Presentation: Tennessee, USA
  • Year and Date: 2016-11-07
  • Int'l Joint Research
• [Presentation] 医学部における「放射線影響リスク科学」教育の推進の現況と課題：オーバービュー (2016)
  • Author(s): 續輝久
  • Organizer: 日本放射線影響学会第59回大会
  • Place of Presentation: 広島市
  • Year and Date: 2016-10-27
• [Presentation] Characterization of mismatch repair factor MSH2 variants found in Lynch syndrome (2016)
  • Author(s): 林田元気、中津可道、日高京子、藤兼亮輔、日高真純、釣本敏樹、續輝久
  • Organizer: 日本放射線影響学会第59回大会
  • Place of Presentation: 広島市
  • Year and Date: 2016-10-27
• [Presentation] プラズマ照射とナノ粒子の安全性評価 (2016)
  • Author(s): 田中昭代
  • Organizer: 第19回プラズマ技術研究
  • Place of Presentation: 福岡市
  • Year and Date: 2016-10-25
  • Invited
• [Presentation] Disinfection of Fungal Spores on Citrus using Belt Conveyor Type Device (2016)
  • Author(s): Y. Yagyu, T. Miyamoto, M. Yamaguchi, T. Ihara, T. Ohshima, H. Kawasaki
  • Organizer: The First International Conference on Hybridized Agriculture(HA2016）
  • Place of Presentation: Kumamoto, Japan
  • Year and Date: 2016-10-22
  • Int'l Joint Research
• [Presentation] Advantages of Plasma Agriculture (2016)
  • Author(s): M. Shiratani, T. Sarinont, K. Koga
  • Organizer: The First International Conference on Hybridized Agriculture(HA2016）
  • Place of Presentation: Kumamoto, Japan
  • Year and Date: 2016-10-22
  • Int'l Joint Research
• [Presentation] Comparative study of non-thermal atmospheric pressure discharge plasmas for life science applications (2016)
  • Author(s): K. Koga, R. Katayama, T. Sarinont, H. Seo, N. Itagaki, P. Attri, E. L. Quiros, .A. Tanaka, M. Shiratani
  • Organizer: 69th Annual Gaseous Electronics Conference (GEC2016)
  • Place of Presentation: Bochum, Germany
  • Year and Date: 2016-10-12
  • Int'l Joint Research
• [Presentation] 酸化ストレスによる消化管腫瘍発生頻度上昇と特異的体細胞変異シグニチャー： Mutyh欠損マウスを用いた解析 (2016)
  • Author(s): 大野みずき、鷹野典子、中津可道、中別府雄作、續輝久
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-10-07
• [Presentation] ヒト細胞を用いたミスマッチ修復因子MSH2の変異体の解析 (2016)
  • Author(s): 林田元気、中津可道、日高京子、藤兼亮輔、日高真純、續輝久
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-10-07
• [Presentation] プラズマを用いた搬送型殺菌装置の開発 (2016)
  • Author(s): 山口充洋、宮本大毅、柳生義人、猪原武士、大島多美子、川崎仁晴、林信哉、作道章一
  • Organizer: 平成28年度(第69回)電気・情報関係学会九州支部連合大会
  • Place of Presentation: 宮崎市
  • Year and Date: 2016-09-30
• [Presentation] 大気圧プラズマジェット照射によって模擬生体内を輸送された ROS の二次元濃度分布 (2016)
  • Author(s): 川崎敏之、内田儀一郎,、古閑一憲,、白谷正治
  • Organizer: 第40回静電気学会全国大会
  • Place of Presentation: 桐生市
  • Year and Date: 2016-09-29
• [Presentation] Plasma assisted plant growth enhancement for agricultural yield enhancement (2016)
  • Author(s): M. Shiratani, K. Koga
  • Organizer: The 6th International Conference on Microelectronics and Plasma Technology (ICMAP 2016),
  • Place of Presentation: Gyeongju, Korea
  • Year and Date: 2016-09-27
  • Int'l Joint Research / Invited
• [Presentation] ベルトコンベア型プラズマ連続殺菌装置の開発および殺菌特性 (2016)
  • Author(s): 柳生義人、宮本大毅、山口充洋、作道章一、猪原武士、大島多美子、林信哉、川崎仁晴
  • Organizer: 第77回応用物理学会秋季学術講演会
  • Place of Presentation: 新潟市
  • Year and Date: 2016-09-16
• [Presentation] CRISPR/Cas9を用いたヒト細胞のミス マッチ修復因子への変異導入 (2016)
  • Author(s): 林田元気、中津可道、日高京子、 藤兼亮輔、日高真純、釣本敏樹、 續輝久
  • Organizer: 日本遺伝学会第88回大会
  • Place of Presentation: 三島市
  • Year and Date: 2016-09-09
• [Presentation] ミスマッチDNA修復系が体細胞および生殖細胞ゲノムにおよぼす影響 (2016)
  • Author(s): 鷹野典子、大野みずき、 佐々木史子、中津可道、續輝久
  • Organizer: 日本遺伝学会第88回大会
  • Place of Presentation: 三島市
  • Year and Date: 2016-09-09
• [Presentation] プラズマ技術を用いた農産物殺菌装置の開発及び実用化の検討 (2016)
  • Author(s): 山口充洋、宮元大毅、柳生義人、猪原武士、大島多美子、川崎仁晴、林信弥、作道章一
  • Organizer: 2016年（第34回）電気設備学会全国大会
  • Place of Presentation: 岡山市
  • Year and Date: 2016-09-07
• [Presentation] Effects of Non-thermal Atmospheric-Pressure Plasma Irradiation on Skin in Hairless Mice (2016)
  • Author(s): S. Kitazaki, A. Tanaka, M. Hirata, Y. Nakatsu, K. Koga, M. Shiratani
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] Health Effects of Repeated Intraperitoneal Injections of Plasma-activated Medium in Mice (2016)
  • Author(s): A. Tanaka, M. Hirata, Y. Ikehara, Y. Akimoto, H. Nakanish, H.Tanaka, M. Hori
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] DNA Damage and Apoptosis Induction in Cells Irradiated by Non-thermal Atmospheric Air Plasma (2016)
  • Author(s): K. Koga, T. Amano, Y. Nakatsu, H. Seo, N. Itagaki, A. Tanaka, T. Kond, M. Shiratani
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] Mutagenesis in Human and Mouse Cells Irradiated by Non-thermal Atmospheric Air Plasma (2016)
  • Author(s): Y. Nakatsu, N. Takano, M. Ohno, S. Kitazaki, K. Koga, T. Amano, A. Tanaka, M. Hirata, M. Shiratani, T. Tsuzuki
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] A comparative study for action of gamma and plasma irradiation dose on thermodynamics of protein (2016)
  • Author(s): M. Shiratani, P. Attri, T. Sarinont, E. H. Choi, K. Koga
  • Organizer: 6th International Conference on Plasma Medicine (ICPM6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] A comparative study of reactive oxygen species dose provided by atmospheric plasma and gamma ray irradiation using iodine-starch reaction (2016)
  • Author(s): T. Sarinont, P. Attri, E. H. Choi, K. Koga, M. Shiratani
  • Organizer: 6th International Conference on Plasma Medicine (ICPM6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] Gene Expression Analysis of Saccharomyces cerevisiae Exposed to FE-DBD Plasma (2016)
  • Author(s): Y. Yagyu, N. Hayashi, T. Yamasaki, T. Ohshima, M. Koshimrura, T. Miyamoto, T. Ihara, H. Kawasaki, K. Koga, M. Shiratani
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] Effects of plasma-irradiation distance on ROS and RNS productions in liquid (2016)
  • Author(s): G. Uhcida, A. Nakajima, T. Ito, K. Takenaka, T. Kawasaki, K. Koga, M. Shiratani, Y. Setsuhara
  • Organizer: 6th International Conference on Plasma Medicine (ICPM6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] Time development of response of cells irradiated by non-thermal atmospheric air plasma (2016)
  • Author(s): K. Koga, T. Amano, Y. Nakatsu, H. Seo, N. Itagaki, A. Tanaka, T. Kondo, M. Shiratani
  • Organizer: 6th International Conference on Plasma Medicine (ICPM6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04 – 2016-09-09
  • Int'l Joint Research
• [Presentation] Nitrite concentration of plants grown from seeds irradiated by air dielectric barrier discharge plasmas (2016)
  • Author(s): K. Koga, T. Sarinont, P. Attri, M. Shiratani
  • Organizer: 20th International Vacuum Congress (IVC-20)
  • Place of Presentation: Busan, Korea
  • Year and Date: 2016-08-24
  • Int'l Joint Research
• [Presentation] Effects of atmospheric pressure plasma irradiation to plant seeds put in magnetic field on the plant growth (2016)
  • Author(s): T. Sarinont, P. Attri, K. Koga, M. Shiratani
  • Organizer: 20th International Vacuum Congress (IVC-20)
  • Place of Presentation: Busan, Korea
  • Year and Date: 2016-08-24
  • Int'l Joint Research
• [Presentation] インジウムナノ粒子のラット皮下投与による体内動態 (2016)
  • Author(s): 田中昭代、平田美由紀、松村 渚、古閑一憲、白谷正治
  • Organizer: 第27回日本微量元素学会
  • Place of Presentation: 京都
  • Year and Date: 2016-07-30 – 2016-07-31
• [Presentation] 疾患モデルマウスを用いた研究：酸化ストレス誘発発がんの抑制に関与する分子機構の解明 (2016)
  • Author(s): 續輝久
  • Organizer: 第53回放射線影響懇話会
  • Place of Presentation: 大分
  • Year and Date: 2016-07-16
  • Invited
• [Presentation] 「プラズマ」による低温・ドライ殺菌 技術および品質保持 (2016)
  • Author(s): 柳生義人、作道章一、三沢達也、西岡輝美、三島朋子
  • Organizer: 2016国際食品工業展アカデミックプラザ
  • Place of Presentation: 東京都江東区
  • Year and Date: 2016-06-07 – 2016-06-10
• [Presentation] インジウムを構成元素とする化合物半導体IGZOの亜慢性毒性評価 (2016)
  • Author(s): 田中昭代、平田美由紀、松村渚、清原裕
  • Organizer: 第89回日本産業衛生学会
  • Place of Presentation: 福島
  • Year and Date: 2016-05-24 – 2016-05-27
• [Presentation] インジウム曝露ラット肺におけるマイクロRNAと標的遺伝子の発現解析 (2016)
  • Author(s): 平工雄介、田中昭代、平田美由紀、村田真理子
  • Organizer: 第89回日本産業衛生学会
  • Place of Presentation: 福島
  • Year and Date: 2016-05-24 – 2016-05-27
• [Presentation] インジウム曝露と腎影響の関係：時間断面観察 (2016)
  • Author(s): 中野真規子、田中昭代、平田美由紀、吉岡範幸、大前和幸
  • Organizer: 第89回日本産業衛生学会
  • Place of Presentation: 福島
  • Year and Date: 2016-05-24 – 2016-05-27
• [Presentation] Plasma induced multigeneration effects on plant growth and crop yield (2016)
  • Author(s): M. Shiratani, T. Sarinont, K. Koga, N. Hayashi
  • Organizer: 1st International Workshop on Plasma Agriculture (IWOPA)
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2016-05-16
  • Int'l Joint Research / Invited
• [Presentation] インジウム曝露と新規肺がん発生についての現状報告：コホート研究（10年観察） (2016)
  • Author(s): 中野真規子、田中昭代、平田美由紀、吉岡範幸、岩澤聡子、大前和幸
  • Organizer: 第86回日本衛生学会
  • Place of Presentation: 旭川
  • Year and Date: 2016-05-11 – 2016-05-13
• [Presentation] インジウム曝露ラット肺におけるマイクロRNA発現の網羅的解析と標的遺伝子の探索 (2016)
  • Author(s): 平工雄介、田中昭代、平田美由紀、村田真理子
  • Organizer: 第86回日本衛生学会
  • Place of Presentation: 旭川
  • Year and Date: 2016-05-11 – 2016-05-13
• [Presentation] 大気圧低温プラズマ照射のマウスを用いた影響評価 (2016)
  • Author(s): 田中昭代、平田美由紀、松村渚、北崎訓、天野孝昭、古閑一憲、白谷正治、清原裕
  • Organizer: 第86回日本衛生学会
  • Place of Presentation: 旭川
  • Year and Date: 2016-05-11 – 2016-05-13
• [Presentation] R&D status of agricultural applications of high voltage and plasma in Japan (2016)
  • Author(s): M. Shiratani, T. Sarinont, K. Koga, N. Hayashi
  • Organizer: Workshop on Application of Advanced Plasma Technologies in CE Agriculture
  • Place of Presentation: Ljubljana, Slovenia
  • Year and Date: 2016-04-20
  • Int'l Joint Research / Invited
• [Presentation] プラズマ照射によるヒト口腔癌細胞株に対する抗腫瘍効果の検討 (2016)
  • Author(s): 合島怜央奈、山下佳雄、鶴岡祥子、下平大治、檀上敦、後藤昌昭
  • Organizer: 第70回日本口腔科学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2016-04-16
• [Patent(Industrial Property Rights)] 動植物成長促進方法 (2016)
  • Inventor(s): 林信哉、中東朱里、白谷正治、古閑一憲
  • Industrial Property Rights Holder: 林信哉、中東朱里、白谷正治、古閑一憲
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 016-152796
  • Filing Date: 2016-01-20
  • Acquisition Date: 2016-08-25