Activation and modification of cell/organization with plasma and application to regenerative medicine

2016 Fiscal Year Final Research Report

• Project Area: Plasma medical innovation
• Project/Area Number: 24108010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tokyo City University
• Principal Investigator: Hirata Takamichi 東京都市大学, 工学部, 教授 (80260420)
• Co-Investigator(Kenkyū-buntansha): 筒井 千尋 東京都市大学, 工学部, 講師 (00570699) ; 岩下 光利 杏林大学, 医学部, 教授 (30124936) ; 金井 孝夫 東京女子医科大学, 医学部, その他 (60104642) ; 森 晃 東京都市大学, 工学部, 教授 (60219996) ; 工藤 美樹 広島大学, その他の研究科, 教授 (80241082)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: プラズマ / 大気圧プラズマ / プラズマ医療 / 再生医療

Outline of Final Research Achievements

The use of inhaled plasma, generated by an atmospheric-pressure plasma (APP) reactor, in a rat myocardial infarction (MI) model resulted in increased saturation pulse oxygen (SpO2) in the blood, which suggests that this method can be beneficial in restoring heart function following cardiac ischemia. Additionally, in vivo blood pressure decreased from 89/81 to 73/60 mmHg in the abdominal aorta during plasma inhalation. Nitric oxide (NO) concentrations in the abdominal aorta increased after 20 s of plasma inhalation, reaching a maximum value at about 160 s and gradually decreased thereafter.

Free Research Field

プラズマ理工学