2017 Fiscal Year Final Research Report
Modeling of Reaction Centers of Stimuli-responsive Metalloenzymes and Their Functionality
| Project Area | Stimuli-responsive Chemical Species for the Creation of Functional Molecules |
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| Project/Area Number |
24109015
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IOTH Shinobu 大阪大学, 大学院工学研究科, 教授 (30184659)
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| Research Collaborator |
KITAYAMA Kazuihro
TATEMOTO Susumu
HATAKEDA Kohei
ASHIKARI Kenji
MIKAMI Akine
MAEDA Kazuki
SATO Masanori
KANETAKE Takayuki
KIRIYAMA Kahori
KAI Kenichiro
HIRATA Yuka
AOKI Kurumi
FUJIMOTO Tomohiro
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Keywords | 錯体化学 / 生物無機化学 / 金属酵素 / バイオインスパイアード触媒 |
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| Outline of Final Research Achievements |
Model complexes of oxy-PHM were prepared and examined in dioxygen reactivity. The formed mononuclear Cu(II)-end-on-superoxide complexes exhibited C-H bond hydroxylation at the benzylic position of a ligand phenetyl side arm at higher temperature.
As model complexes of molybdoenzymes, molybdenum complexes having a terminal oxide, sulfide, and selenide group were prepared and the crystal structure, electronic structures, and reactivities were examined in a systematic way.
Model complexes of iron enzymes were synthesized and the reactivities were examined in the oxidation reactions. The complexes were found to catalyze alkene dihydroxylation with hydrogen peroxide as a terminal oxidant. In the presence of amines, the alkenes were converted to aminoalcohols. When 1,5-dienes were employed as the substrate, the oxidative cyclization proceeded to yield the corresponding tetrahydrofurans.
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| Free Research Field |
錯体化学
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