2017 Fiscal Year Final Research Report
Moleculara mechanism and regulation of the lymphoid organ
| Project Area | Analysis and synthesis of multi-dimensional immune organ network |
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| Project/Area Number |
24111002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Okazaki Research Facilities, National Institutes of Natural Sciences |
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Principal Investigator |
TAKADA Shinji 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (60206753)
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| Co-Investigator(Kenkyū-buntansha) |
大久保 直 北里大学, 医学部, 准教授 (10450719)
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| Co-Investigator(Renkei-kenkyūsha) |
MII Yusuke 基礎生物学研究所, 分子発生学研究部門, 助教 (70634129)
FUJIMORI Sayumi 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 研究員 (20589717)
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| Research Collaborator |
KONDOH Hisato
TAKEMOTO Tasuya
TAIRA Masanori
YABE Taijiro
CHEN Quihong
TAKADA Ritsuko
OKADA Kazunori
SHINOZUKA Takuma
TSUCHIYA Akihiro
WANGLAR Chimwar
TAKASHIRO Kayoko
ITO Yukiko
UKAI Sakie
NOBATA Ryuko
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Keywords | 遺伝子 / 細胞分化 / シグナル伝達 / 咽頭弓 / 胸腺 |
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| Outline of Final Research Achievements |
One of the goals of this study was to understand the molecular mechanism of the spatial control of the Wnt function in thymic stromal cells. Our results suggest that the Wnt signal promotes proliferation of epithelial cells in the margin of the thymus cortex. We also found that the variation of Wnt protein complexes and that of heparan sulfate proteoglycans in the extracellular space are involved in the regulation of the diffusion pattern of Wnt proteins in model systems. Another goal that we had was to understand the developmental mechanism of the thymus primordia. Our results suggest that the interaction between Ripply3 and several LIM domain proteins, which are known to be involved in adhesion to the extracellular matrix, is required for the proper morphogenesis of the pharyngeal epithelium, from which the thymus is generated.
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| Free Research Field |
発生生物学
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