2016 Fiscal Year Final Research Report
Characteristics and functions of stromal cells in secondary lymphoid tissues
| Project Area | Analysis and synthesis of multi-dimensional immune organ network |
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| Project/Area Number |
24111005
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
片貝 智哉 新潟大学, 医歯学系, 教授 (00324682)
梅本 英司 大阪大学, 医学(系)研究科(研究院), 准教授 (90452440)
早坂 晴子 近畿大学, 理工学部, 准教授 (70379246)
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| Research Collaborator |
Takeda Akira Turku大学, 博士研究員
Sirpa Jalkanen Turku大学, 教授
Malko Salmi Turku大学, 教授
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Keywords | ストローマ細胞 / リゾリン脂質 / ケモカイン / ケモカイン受容体 / リンパ球 |
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| Outline of Final Research Achievements |
In collaboration with Drs. A. Takeda, S. Jalkanen, and M. Salmi of University of Turku, Finland, the principal investigator, M. Miyasaka, and the co-investigator, E. Umemoto, found that a specific stromal subset secretes multiple bioactive molecules that regulate lymphocyte trafficking into and within lymph nodes. They also found that a different stromal subset mediates transport of small-molecular substances from the lymphatic sinus into the lymph node parenchyma. A co-investigator, H. Hayasaka, identified a mechanism whereby a chemokine induces homo- and hetero-oligomerization of chemokine receptors. A co-investigator, T. Katakai, analyzed stromal cells in lymph nodes in detail and identified a novel stromal subset.
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| Free Research Field |
免疫学
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