2017 Fiscal Year Final Research Report
Role of motile and immotile cilia in left-right symmetry breaking
| Project Area | Cilium-centrosome system regulating biosignal flows |
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| Project/Area Number |
24113004
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Institute of Physical and Chemical Research (2016-2017)
Osaka University (2012-2015) |
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Principal Investigator |
Hamada Hiroshi 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, チームリーダー (00208589)
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| Co-Investigator(Kenkyū-buntansha) |
広野 雅文 法政大学, 生命科学部, 教授 (10212177)
岸本 健雄 お茶の水女子大学, サイエンス&エデュケーションセンター, 客員教授 (00124222)
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Keywords | 発生制御 / 発生・分化 / 左右非対称性 / 繊毛 / 水流 |
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| Outline of Final Research Achievements |
We have revealed how left-right asymmetry of our body is established during development. In particular, we have clarified the following questions about node cilia, cilia that break left-right symmetry: 1) how node cilia are formed correctly with posterior tilt, 2) how node cilia acquire motility, 3) why node cilia can rotate unlike other cilia such as those in the airway, 4) how embryos sense the uni-directional fluid flow that is generated by rotating cilia.
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| Free Research Field |
生物科学
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