2016 Fiscal Year Final Research Report
Cytokine-Induced Neuropathologic Endophenotypes of Psychiatric Diseases
| Project Area | Unraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels. |
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| Project/Area Number |
24116010
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAMBA Hisaaki 新潟大学, 脳研究所, 助教 (90332650)
KAKITA Akiyoshi 新潟大学, 脳研究所, 教授 (80281012)
TAKEI Nobuyuki 新潟大学, 脳研究所, 准教授 (70221372)
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| Research Collaborator |
KIDA Satoshi 東京農業大学, 応用生物科学部, 教授 (80301547)
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Keywords | 統合失調症 / 幻聴 / サイトカイン / ドパミン / 上皮成長因子 / 神経栄養因子 / ニューレグリン / 脳波 |
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| Outline of Final Research Achievements |
The animals that had been exposed to cytokines as neonates later develop the abnormal behaviors relevant to schizophrenia. In the present investigation, we explored the cytokine animal model for schizophrenia, focusing on the monoaminergic pathways. Among various cytokines, epidermal growth factor (EGF) produced the most remarkable impact on animal behaviors. In the EGF model, dopaminergic neurons exhibited abnormal pallidal innervations and a postpubertal firing increase as well as their antipsychotic sensitivity. There were no significant influences on the other monoaminergic neurons in the EGF model. In addition, the EGF model in rats displayed the remarkable deficits particularly in the auditory system. These observations suggest that prenatal or perinatal cytokine exposure results in dopaminergic mal-development and deficits in auditory cognition.
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| Free Research Field |
神経発達学、分子精神医学
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