2016 Fiscal Year Final Research Report
Elucidation of information-processing mechanisms during transcription cycle using computational and information sciences
| Project Area | Integral understanding of the mechanism of transcription cycle through quantitative, high-resolution approaches |
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| Project/Area Number |
24118008
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤井 聡 九州工業大学, 大学院情報工学研究院, 助教 (40452825)
皿井 明倫 九州工業大学, その他の研究科, 教授 (20221286)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIYA Narutoshi 兵庫県立大学, シミュレーション学研究科, 特任教授 (80420462)
KONO Hidetoshi 量子科学技術研究開発機構, 量子生命科学研究部, 生体分子シミュレーショングループリーダー (40291918)
KASAHARA Kota 立命館大学, 生命科学部, 助教 (90634965)
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| Research Collaborator |
IIDA Midori
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Keywords | 転写因子 / 遺伝子 / 分子動力学計算 / 生体生命情報学 / 生物物理 / 生体分子 / 蛋白質 / ポリメラーゼ |
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| Outline of Final Research Achievements |
In order to reveal the dynamic properties of the information transduction at the transcription cycle, new computational and informatics approaches have been developed. For the transcription factors in the enhanceosome and the relation to nucleosome, dynamic structural changes and the stabilities of the supramolecular complexes were analyzed so as to analyze the actual mechanisms in the transcription cycle. In addition, to extract biologically important and meaningful information and knowledges from the large scale data produced by the members of the research groups of the Transcription Cycle, mechanisms of transcription regulation were investigated based on the experimental data of Micro-array, RNA-seq, and ChIP-seq.
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| Free Research Field |
生物物理学
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