Exploration of micro-macro relationships in dynamic ordering of biomolecular systems and their underlying design principles

2017 Fiscal Year Final Research Report

• Project Area: Dynamical ordering of biomolecular systems for creation of integrated functions
• Project/Area Number: 25102008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Okazaki Research Facilities, National Institutes of Natural Sciences
• Principal Investigator: Kato Koichi 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (20211849)
• Co-Investigator(Kenkyū-buntansha): 山口 拓実 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 准教授 (60522430) ; 佐藤 匡史 名古屋市立大学, 大学院薬学研究科, 准教授 (80532100) ; 栗原 顕輔 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 特任准教授 (80740919) ; 矢木 真穂 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 助教 (40608999)
• Co-Investigator(Renkei-kenkyūsha): YAGI Maho 分子科学研究所, 生命・錯体分子科学研究領域, 助教 (40608999) ; YANAKA Saeko 分子科学研究所, 生命・錯体分子科学研究領域, 助教 (80722777)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: 動的秩序 / 生命分子 / 超分子 / 集合離散 / NMR / プロテアソーム

Outline of Final Research Achievements

Biomolecules with complicated, flexible structures are self-organized through weak interactions giving rise to supermolecular complexes that adopt their own dynamic, asymmetric architectures. These processes are coupled with expression of integrated functions in the biomolecular systems. Toward an integrative understanding of the principles behind the biomolecular ordering processes, we integrated multidisciplinary approaches based on detailed analyses of dynamic structures and interactions of biomolecules at atomic level, in conjunction with the methodologies of molecular and cellular biology along with synthetic and computational techniques.

Free Research Field

構造生物学