2017 Fiscal Year Final Research Report
Dynamic ordering of cellular functions through self-assembly of component molecules
Project Area | Dynamical ordering of biomolecular systems for creation of integrated functions |
Project/Area Number |
25102010
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Science and Engineering
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Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
Inagaki Naoyuki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (20223216)
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Project Period (FY) |
2013-06-28 – 2018-03-31
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Keywords | 神経細胞 / 軸索 / アクチン / 自己組織化 / メカノバイオロジー |
Outline of Final Research Achievements |
In this study, we identified a molecular assembly, consists of shootin1, cortactin and L1-CAM, which is involved in neuronal axon outgrowth and guidance. This molecular assembly senses shallow gradients of extracellular netrin-1 concentration and decides the direction of axon outgrowth through its spatially regulated assembly and disassembly. This assembly is also involved in a new type of axon guidance mechanism which utilizes mechanical slippage between L1-CAM and adhesive substrates. This mechanism is disrupted in a human patient of L1-CAM/CRASH syndrome, suffering corpus callosum agenesis and corticospinal tract hypoplasia. Furthermore, the molecular assembly, consists of shootin1, cortactin and L1-CAM, mediates cell migration and a new type of intracellular molecular transport mechanism.
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Free Research Field |
細胞生物学
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