• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Annual Research Report

Non-equilibrium dynamics of meso-structures in biomembranes

Planned Research

Project AreaSynergy of Fluctuation and Structure:Foundation of Universal Laws in Nonequilibrium Systems
Project/Area Number 25103010
Research InstitutionTokyo Metropolitan University

Principal Investigator

好村 滋行  首都大学東京, 理工学研究科, 准教授 (90234715)

Co-Investigator(Kenkyū-buntansha) 野口 博司  東京大学, 物性研究所, 准教授 (00514564)
芝 隼人  東北大学, 金属材料研究所, 特任助教 (20549563)
Project Period (FY) 2013-06-28 – 2018-03-31
Keywords生体膜 / 非平衡 / 相分離 / 化学反応 / ずり流動 / ラフト / マイクロレオロジー / ガラス
Outline of Annual Research Achievements

アクティブな力双極子を有する粘弾性体中のブラウン運動について検討した。プローブ粒子の平均二乗変位を計算した結果、熱ゆらぎのみ存在する場合、平均二乗変位は時間の0乗から1乗の間で変化することを導出した。一方、アクティブな力双極子によって、平均二乗変位は時間の0乗から2乗の間の全ての異常拡散が起こることを示した。
ソフトマターのような粘弾性体中を遊泳するマイクロマシンの動作機構について理論的に考察した。具体的には、アクティブ・マイクロレオロジーで使われている基本式を三つ玉スイマーに適用することで、スイマーの遊泳速度とソフトマターの複素粘性率を結びつける関係式を導出した。この関係式によると、三つ玉スイマーがソフトマター中を遊泳するには二通りの可能性があり、一方は形状変形の時間反転対称性を破ることであり、他方はスイマーの構造対称性を破ることである。
生体内では脂質分子の合成、分解が盛んに行われているが、それによって生じる生体膜のダイナミクスはよくわかっていない。親水分子、疎水分子の結合による両親媒性分子の生成、また逆反応による分解を考慮した粗視化分子動力学計算を行い、二重膜の構造変化を研究した。ベシクルの内外に基質の濃度差がある場合、化学反応によって、二重膜の外膜と内膜の間を分子の移動が起こる。これにより、板状の二重膜の形成伸長、ベシクル内への球状のコブ形成が起こることが明らかにした。
イオンのみで液体状態を取る常温溶融塩が電解液、反応溶媒、潤滑剤などとして近年注目されており、メソスケールの内部構造が機能性発現に重要であることが実験的に示唆されている。アルキルイミダゾリウム系イオン液体の合同原子モデルの1マイクロ秒に渡る長時間分子動力学計算により液晶構造の形成を再現し、液晶構造がフラジャイルな動的性質に寄与すること、液晶構造によってイオン輸送が層内に制約され異方的となることを見出した。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

  • Research Products

    (34 results)

All 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (12 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 12 results) Presentation (18 results) (of which Int'l Joint Research: 17 results,  Invited: 4 results) Remarks (1 results)

  • [Int'l Joint Research] Tel Aviv University(Israel)

    • Country Name
      Israel
    • Counterpart Institution
      Tel Aviv University
  • [Int'l Joint Research] Indian Institute if Technology Madras(India)

    • Country Name
      India
    • Counterpart Institution
      Indian Institute if Technology Madras
  • [Int'l Joint Research] University Paris Diderot(フランス)

    • Country Name
      FRANCE
    • Counterpart Institution
      University Paris Diderot
  • [Journal Article] Kosmotropic effect leads to LCST decrease in thermoresponsive polymer solutions2018

    • Author(s)
      Swaminath Bharadwaj, P. B. Sunil Kumar, Shigeyuki Komura, and Abhijit P. Deshpande
    • Journal Title

      The Journal of Chemical Physics

      Volume: 148 Pages: 084903/1-12

    • DOI

      https://doi.org/10.1063/1.5012838

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dynamics of a bilayer membrane with membrane-solvent slip boundary conditions2018

    • Author(s)
      Kento Yasuda, Ryuichi Okamoto, Shigeyuki Komura, and Jean-Baptiste Fournier
    • Journal Title

      Soft Materials

      Volume: 印刷中 Pages: 印刷中

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Thermal and active fluctuations of a compressible bilayer vesicle2018

    • Author(s)
      T V Sachin Krishnan, Kento Yasuda, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Journal of Physics: Condensed Matter

      Volume: 30 Pages: 175101/1-9

    • DOI

      https://doi.org/10.1088/1361-648X/aab6c7

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Isolating long-wavelength fluctuation from structural relaxation in two-dimensional glass: cage-relative displacement2018

    • Author(s)
      Hayato Shiba, Peter Keim, and Takeshi Kawasaki
    • Journal Title

      Journal of Physics: Condensed Matter

      Volume: 30 Pages: 094004/1-9

    • DOI

      http://dx.doi.org/10.1088/1361-648X/aaa8b8

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular dynamics study of mesophase transition upon annealing of imidazolium-based ionic liquid with long-alkyl chain2018

    • Author(s)
      Hailong Peng, Momoji Kubo, and Hayato Shiba
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 印刷中 Pages: 印刷中

    • DOI

      http://dx.doi.org/10.1039/C8CP00698A

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lateral diffusion induced by active proteins in a biomembrane2017

    • Author(s)
      Yuto Hosaka, Kento Yasuda, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Physical Review E

      Volume: 95 Pages: 052407/1-10

    • DOI

      https://doi.org/10.1103/PhysRevE.95.052407

    • Peer Reviewed
  • [Journal Article] Dynamics of a bilayer membrane coupled to a two-dimensional cytoskeleton: Scale transfers of membrane deformations2017

    • Author(s)
      Ryuichi Okamoto, Shigeyuki Komura, and Jean-Baptiste Fournier
    • Journal Title

      Physical Review E

      Volume: 96 Pages: 012416/1-10

    • DOI

      https://doi.org/10.1103/PhysRevE.96.012416

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Elastic three-sphere microswimmer in a viscous fluid2017

    • Author(s)
      Kento Yasuda, Yuto Hosaka, Mizuki Kuroda, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 86 Pages: 093801/1-4

    • DOI

      https://doi.org/10.7566/JPSJ.86.093801

    • Peer Reviewed
  • [Journal Article] Thermally driven elastic micromachines2017

    • Author(s)
      Yuto Hosaka, Kento Yasuda, Isamu Sou, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 86 Pages: 113801/1-4

    • DOI

      https://doi.org/10.7566/JPSJ.86.113801

    • Peer Reviewed
  • [Journal Article] Coexistences of lamellar phases in ternary surfactant solutions2017

    • Author(s)
      Isamu Sou, Ryuichi Okamoto, Shigeyuki Komura, and Jean Wolff
    • Journal Title

      Soft Materials

      Volume: 15 Pages: 272-281

    • DOI

      https://doi.org/10.1080/1539445X.2017.1354024

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Permeation through a lamellar stack of lipid mixtures2017

    • Author(s)
      Takuma Hoshino, Shigeyuki Komura, and David Andelman
    • Journal Title

      EPL

      Volume: 120 Pages: 18004/1-7

    • DOI

      https://doi.org/10.1209/0295-5075/120/18004

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Membrane structure formation induced by two types of banana-shaped proteins2017

    • Author(s)
      Hiroshi Noguchi and Jean-Baptiste Fournier
    • Journal Title

      Soft Matter

      Volume: 13 Pages: 4099-4111

    • DOI

      http://dx.doi.org/10.1039/c7sm00305f

    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Shape Transformation of Biomembrane Induced by Banana-Shaped Protein Rods2018

    • Author(s)
      Hiroshi Noguchi
    • Organizer
      Biophysical Society 62nd Annual Meeting, San Francisco, USA
    • Int'l Joint Research
  • [Presentation] Coarse-Grained Simulations of Biomembranes Using Meshless Membrane Model2018

    • Author(s)
      Hiroshi Noguchi
    • Organizer
      SIAM Conference on Parallel Processing for Scientific Computing, Tokyo, Japan
    • Int'l Joint Research / Invited
  • [Presentation] Simulation study of fluctuation and dynamics in low-dimensional systems: crystal melting, amorphous solids, and elastic membranes2018

    • Author(s)
      Hayato Shiba
    • Organizer
      Workshop on Computer Simulation of Glassy Materials, Changsha, China
    • Int'l Joint Research / Invited
  • [Presentation] 大規模シミュレーションを用いた分子集合体の普遍ゆらぎの開拓(若手奨励賞受賞記念講演)2018

    • Author(s)
      芝隼人
    • Organizer
      日本物理学会第 73回年次大会
    • Invited
  • [Presentation] Membrane Shape Transformation Induced by Banana-Shaped Proteins2017

    • Author(s)
      Hiroshi Noguchi
    • Organizer
      19th IUPAB congress and 11th EBSA congress, Edinburgh, UK
    • Int'l Joint Research
  • [Presentation] Unveiling Dimensionality Dependence of Glassy Dynamics: 2D Infinite Fluctuation Eclipses Inherent Structural Relaxation2017

    • Author(s)
      Hayato Shiba
    • Organizer
      10th Liquid Matter Conference, Ljubljana, Slovenia
    • Int'l Joint Research
  • [Presentation] Swimmer-microrheology2017

    • Author(s)
      Shigeyuki Komura
    • Organizer
      Association in Solution IV, St. John’s, Canada
    • Int'l Joint Research / Invited
  • [Presentation] Elastic three-sphere microswimmer in a viscous fluid2017

    • Author(s)
      Mizuki Kuroda, Kento Yasuda, Yuto Hosaka, Ryuichi Okamoto, and Shigeyuki Komura
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Anomalous diffusion in viscoelastic media with active force dipoles2017

    • Author(s)
      Shigeyuki Komura, Kento Yasuda, Ryuichi Okamoto, and Alexnder S. Mikhailov
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Pattern formation of skin cancer: Effects of hydrodynamic interactions2017

    • Author(s)
      Takuma Hoshino, Shigeyuki Komura, Hsuan-Yi Chen, and Kuo-An Wu
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Stochastic properties of an active force dipole2017

    • Author(s)
      Yuto Hosaka, Shigeyuki Komura, and Alexander S. Mikhailov
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Membrane Shape Transformation Induced by Banana-Shaped Proteins2017

    • Author(s)
      Hiroshi Noguchi
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Smectic Phase Formation in Imidazolium-Based Ionic Liquids with Long Alkyl Chain: the Role of Orientational Dynamics2017

    • Author(s)
      Hailong Peng and Hayato Shiba
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Unveiling Dimensionality Dependence of Glassy Dynamics: 2D Infinite Fluctuation Eclipses Inherent Structural Relaxation2017

    • Author(s)
      Hayato Shiba, Yasunori Yamada, Takeshi Kawasaki, and Kang Kim
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Swimmer-microrheology2017

    • Author(s)
      Kento Yasuda, Ryuichi Okamoto, and Shigeyuki Komura
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Morphogenesis of small intestinal villus2017

    • Author(s)
      Yuki Umemura, Takuma Hoshino, and Shigeyuki Komura
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Coexistences of lamellar phases in ternary surfactant solutions2017

    • Author(s)
      Isamu Sou, Ryuichi Okamoto, Shigeyuki Komura, and Jean Wolff
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Presentation] Dynamics of the cell membrane coupled to cytoskeleton2017

    • Author(s)
      Chia-Chun Liang, Kento Yasuda, Shigeyuki Komura, and Hsuan-Yi Chen
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Int'l Joint Research
  • [Remarks] 好村滋行のバイオ・ソフトマター研究

    • URL

      www.comp.tmu.ac.jp/shigekomura/

URL: 

Published: 2018-12-17   Modified: 2022-05-18  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi