Structural diversity and hydration dynamics of hydrogen bonding system studied by gas-phase spectroscopy

2017 Fiscal Year Final Research Report

• Project Area: Science on Function of Soft Molecular Systems by Cooperation of Theory and Experiment
• Project/Area Number: 25104008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Fujii Masaaki 東京工業大学, 科学技術創成研究院, 教授 (60181319)
• Co-Investigator(Kenkyū-buntansha): 宮崎 充彦 東京工業大学, 科学技術創成研究院, 助教 (00378598) ; 石内 俊一 東京工業大学, 科学技術創成研究院, 准教授 (40338257) ; 石川 春樹 北里大学, 理学部, 教授 (80261551)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: 分子分光 / レーザー分光 / 原子・分子物理 / 分子クラスター / 低温イオン / 分子認識 / コンフォメーション

Outline of Final Research Achievements

Electrospray cryogenic ion trap spectrometer was developed, and applied to complexes of partial sequence of receptor proteins and several ligands to reveal their interactions at molecular level. In addition, hydration effects on their structures were clarified by using hydrated clusters in which number of water molecules and their orientation can be rigorously determined. Furthermore, Structures of alkali metal ion complexes of biomolecules were investigated by using isomer-selected infrared spectroscopy, and conformational specificity depending on the alkali metal ions was revealed. Through these results, we successfully demonstrated that precise spectroscopic studies on the interaction centers cut out from biomolecules, i.e., "bottom-up approach" is useful.

Free Research Field

物理化学、分子分光学