2017 Fiscal Year Final Research Report
Membrane dynamics in autophagy: its molecular machinery and linkage to diseases
| Project Area | Multidisciplinary research on autophagy: from molecular mechanisms to disease states |
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| Project/Area Number |
25111002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-06-28 – 2018-03-31
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| Keywords | オートファジー |
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| Outline of Final Research Achievements |
We have investigated molecular machinery of membrane dynamics in autophagy and relationship between autophagy and diseases. In results, we showed that inositol polyphosphate-5-phosphatase E (INPP5E) involved in autophagosome-lysosome fusion process via actin polymerization on lysosomes. INPP5E is one of the genes responsible for Joubert syndrome, a brain abnormality. We demonstrated a possibility that defect in autophagy causes this disease. In addition, we revealed that endothelial cells have a defect in autophagy against invading bacteria in contrast to epithelial cells, which is caused by their intrinsic inability to target bacteria with ubiquitin that acts a tag for autophagosome formation.
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| Free Research Field |
細胞生物学
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