2017 Fiscal Year Final Research Report
Elucidation of molecular functions of autophagy-related proteins using yeast and cell-free systems
| Project Area | Multidisciplinary research on autophagy: from molecular mechanisms to disease states |
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| Project/Area Number |
25111003
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2013-06-28 – 2018-03-31
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| Keywords | オートファジー / 細胞小器官 / 細胞内輸送 / 細胞内分解 / 飢餓応答 / 酵母 |
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| Outline of Final Research Achievements |
Autophagy is a major degradation system within cells, which plays a wide range of physiological roles and is linked to a number of human diseases. However, fundamental issues still remain to be addressed in the molecular mechanisms of autophagy, which is required to develop therapeutic methods for related diseases. In this study, we used yeast as an excellent model organism for the study of molecular mechanisms of basic biological phenomena and cell-free systems composed of purified proteins and artificial membranes which allow us to analyze the functions of related molecules. Finally, we obtained many important results about molecular mechanisms underlying the biogenesis of the autophagosome, a central event in autophagy, and degradation targets and regulatory mechanisms of selective types of autophagy, which specifically degrade certain components of cells.
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| Free Research Field |
分子細胞生物学
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