Physiological and pathophysiological roles for autophagy and its molecular basis

2017 Fiscal Year Final Research Report

• Project Area: Multidisciplinary research on autophagy: from molecular mechanisms to disease states
• Project/Area Number: 25111005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: Mizushima Noboru 東京大学, 大学院医学系研究科(医学部), 教授 (10353434)
• Co-Investigator(Kenkyū-buntansha): 塚本 智史 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 技術安全部, 主任研究員(定常) (80510693)
• Co-Investigator(Renkei-kenkyūsha): MATSUMOTO Naomichi 横浜市立大学, 大学院医学研究科, 教授 (80325638)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: オートファジー / 細胞内分解 / リソソーム

Outline of Final Research Achievements

Autophagy is a lysosome-mediated degradation system for cytoplasmic materials and it has become clear that autophagy is related to various biological phenomena. Under this Project, we elucidated the molecular mechanisms underlying autophagosome formation, autophagosome-lysosome fusion, and autophagosomal membrane degradation, as well as novel physiological roles for autophagy in mice. Furthermore, a novel reporter to monitor autophagic activity was established, and autophagy-modulating drugs were aslo identified.

Free Research Field

分子細胞生物学