Elucidation of metabolic network underlying plant development

2018 Fiscal Year Final Research Report

• Project Area: Multidimensional Exploration of Logics of Plant Development
• Project/Area Number: 25113010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Hirai Masami 国立研究開発法人理化学研究所, 環境資源科学研究センター, チームリーダー (90415274)
• Co-Investigator(Kenkyū-buntansha): 望月 敦史 国立研究開発法人理化学研究所, 開拓研究本部, 主任研究員 (10304726) ; 及川 彰 山形大学, 農学部, 准教授 (50442934)
• Research Collaborator: SAWADA Yuji ; LI Yimeng ; SAKAI Yuji ; SRIYUDTHSAK Kansuporn ; OKAMURA Eiji ; KAWADE Kensuke ; VERGARA Fredd
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: 代謝ネットワーク / 発生 / メタボロミクス / 数理モデリング / 分子遺伝学

Outline of Final Research Achievements

Metabolism is a basis of life, but its dynamics and regulatory function in development have not been fully understood. In this study, we aimed to understand the dynamics of plant metabolic system via a mathematical approach, and to identify metabolic pathways that regulate developmental processes by molecular genetics. We performed integrated mathematical and biological studies, i.e., theory construction and its application, and, prediction and confirmation, which have led to understanding of several developmental processes. We also clarified by a molecular genetic approach that a metabolic enzyme CYP77A4-mediated metabolic pathway regulates patterning of Arabidopsis embryo.

Free Research Field

植物代謝生理

Academic Significance and Societal Importance of the Research Achievements

代謝が発生過程を制御するという概念を導入することで、発生生物学および代謝生理学における新たな研究戦略を確立した。また、数理的手法を取り入れることで、発生と代謝のダイナミクスの解明を可能とした。