2018 Fiscal Year Final Research Report
Molecular, cellular and circuit mechanisms underlying olfactory memory dynamism in zebrafish
| Project Area | Principles of memory dynamism elucidated from a diversity of learning systems |
|---|
| Project/Area Number |
25115005
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
Yoshihara Yoshihiro 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (20220717)
|
|---|
| Research Collaborator |
MIYASAKA Nobuhiko
KOIDE Tetsuya
HIRAKI Towako (KAJIYAMA Towako)
WAKISAKA Noriko
MASUDA Miwa
YABUKI Yoichi
|
|---|
| Project Period (FY) |
2013-06-28 – 2018-03-31
|
| Keywords | 嗅覚記憶 / ゼブラフィッシュ / 報酬学習 / 神経回路 / 誘引行動 / 忌避行動 / 連合記憶 |
|---|
| Outline of Final Research Achievements |
In this study, we investigated molecular, cellular and circuit mechanisms underlying spatial and temporal dynamism of olfactory memory by using zebrafish as a model organism. First, we identified the four olfactory centers in the zebrafish forebrain (ventral telencephalon, posterior telencephalon, right habenula, posterit tuberculum) where odor information is conveyed from the mitral cells in the olfactory bulb. Next, we analyzed neural mechanism for appetitive olfactory conditioning in which fish are memorized with a given odorant stimulus associated with food reward. Finally, we dissected two distinct olfactory neural circuits that mediate attractive responses to food odors (amino acids and nucleotides) or sex pheromone (prostaglandin F2a). These findings will shed light on elucidation of commonality and difference between the innate and learned behaviors of animals.
|
| Free Research Field |
神経科学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究で得られた成果は、動物が生まれながらにしてとる生得的行動と、生後の経験や学習によって形作られる習得的行動の神経機構の相違性及び共通性の解明に役立つであろう。また、サケの母川回帰や人間のプルースト効果として知られている超長期にわたる嗅覚記憶の神経回路メカニズムの解明にも貢献が期待される。さらには、嗅覚刺激によって誘起される「好き・嫌い」、「快・不快」などの情動、その後のポジティブあるいはネガティブな意欲行動の発現へと至る神経機構の解明にも繋がるであろう。
|
