Molecular basis of the nuclear envelope to ensure chromatin functions

2017 Fiscal Year Final Research Report

• Project Area: Dynamic chromatin structure and function
• Project/Area Number: 25116006
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute of Information and Communications Technology
• Principal Investigator: Haraguchi Tokuko 国立研究開発法人情報通信研究機構, 未来ICT研究所フロンティア創造総合研究室, 主任研究員 (20359079)
• Co-Investigator(Kenkyū-buntansha): 淺川 東彦 大阪大学, 生命機能研究科, 准教授 (70399533)
• Research Collaborator: OBUSE CHIKASHI 大阪大学, 大学院理学研究科, 教授 (00273855) ; KOBAYASHI SHOUHEI 国立研究開発法人情報通信研究機構, 未来ICT研究所 フロンティア創造総合研究室, 主任研究員 (40425765)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: 細胞・組織 / 細胞核 / クロマチン / 細胞構造 / タンパク質

Outline of Final Research Achievements

This study aims to understand the nuclear envelope structure that guarantees chromatin functions. Toward this end, we used the beads-induced experimental system, fluorescence live-cell imaging, and molecular genetics. The results showed that the BAF-dependent nuclear envelope formation around the DNA-beads functioned to protect the DNAs from degradation by autophagy. Additionally, the conserved nuclear envelope protein LEM2 functioned to augment heterochromatin formation in the centromeres in fission yeast. Nup132 was required for the centromere functions during meiosis in fission yeast.

Free Research Field

分子遺伝学