Mechanisms of nuclear transport factor/nucleoporin-mediated chromatin regulation

2017 Fiscal Year Final Research Report

• Project Area: Dynamic chromatin structure and function
• Project/Area Number: 25116008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institutes of Biomedical Innovation, Health and Nutrition (2014-2017); Osaka University (2013)
• Principal Investigator: YONEDA Yoshihiro 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所, 研究所長 (80191667)
• Co-Investigator(Kenkyū-buntansha): 岡 正啓 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 細胞核輸送ダイナミクスプロジェクト, プロジェクトリーダー (40432504) ; 安原 徳子 (垣内徳子) 日本大学, 文理学部, 准教授 (90423152)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: 核輸送因子 / ヌクレオポリン / クロマチン / がん / 白血病 / 核膜孔 / 細胞増殖 / 細胞分化

Outline of Final Research Achievements

We found that nuclear transport factor and the component of nuclear pore complex　(nucleoporin) interact with chromatin to regulate the expression of genes involved in cell differentiation or proliferation. Further, our research demonstrated the significance of the interaction between chromatin and importin α1, a nuclear transport factor that is highly expressed in cancer cells, or leukemogenic nucleoporin fusion protein, Nup98HoxA9, for the development of the diseases.

Free Research Field

細胞生物学