Analysis of Chromatin Dynamics In Cell Differentiation

2017 Fiscal Year Final Research Report

• Project Area: Dynamic chromatin structure and function
• Project/Area Number: 25116010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University
• Principal Investigator: Ohkawa Yasuyuki 九州大学, 生体防御医学研究所, 教授 (80448430)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: エピゲノム / クロマチン構造 / ヒストンバリアント

Outline of Final Research Achievements

In this project, we analyzed chromatin dynamics upon cellular differentiation. Especially, we have focused on the functions of tissue-specific histone H3 variant genes which we identified in 2015 in this project. A representative study published this year reports that H3mm7, a skeletal muscle satellite dominant histone H3 variant, was required for normal skeletal muscle regeneration upon injury. H3mm7 was shown to be involved in the loosening of chromatin structure by forming “mobile” nucleosomes in which the absence of the interaction between H3.3S57 and H4R40 was observed. This project has led to more than 57 published papers based on the genome-wide study of chromatin dynamics.

Free Research Field

トランスクリプトミクス