2017 Fiscal Year Final Research Report
Analysis of glia-assembly by visualization and control of calcium signal
| Project Area | Glial assembly: a new regulatory machinery of brain function and disorders |
|---|
| Project/Area Number |
25117002
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Nihon University (2016-2017)
The University of Tokyo (2013-2015) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
金丸 和典 東京大学, 大学院医学系研究科(医学部), 助教 (10456105)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKUBO Yohei 東京大学, 大学院医学系研究科, 講師 (40422282)
SEKIYA Hiroshi 東京大学, 大学院医学系研究科, 助教 (40511374)
|
|---|
| Project Period (FY) |
2013-06-28 – 2018-03-31
|
| Keywords | シグナル伝達 / 生体分子 / 薬理学 / 脳・神経 / 脳神経疾患 |
|---|
| Outline of Final Research Achievements |
Considering that astrocytes generate intracellular Ca2+ signals to regulate their functions, we established an experimental system in which astrocytic Ca2+ signals could be visualized in vivo. Using the new experimental system, we found previously unrecognized transient and spontaneous Ca2+ signals at fine processes of astrocytes. We extended the method to monitor intracellular Ca2+ signals in neurons and vascular smooth muscle cells in vivo, and succeeded in comparing the responses of these three cell types in response to sensory stimulation to study the roles of astrocytes in such functions as cerebral blood flow regulation.
|
| Free Research Field |
薬理学
|
