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2017 Fiscal Year Final Research Report

neuroanatomical analysis of neuron-glia correlation in neuronal circuit maturation

Planned Research

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Project AreaGlial assembly: a new regulatory machinery of brain function and disorders
Project/Area Number 25117008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

Fukuyama Hidenao  京都大学, 健康長寿社会の総合医療開発ユニット, 特任教授 (90181297)

Co-Investigator(Kenkyū-buntansha) 植木 孝俊  名古屋市立大学, 大学院医学研究科, 教授 (60317328)
岡戸 晴生  公益財団法人東京都医学総合研究所, その他部局等, その他 (60221842)
植木 美乃  名古屋市立大学, 医学(系)研究科(研究院), 講師 (40467478)
Project Period (FY) 2013-06-28 – 2018-03-31
Keywordsneuroimaging / MRI / PET / molecular imaging / microglia / connectome
Outline of Final Research Achievements

We found a lot of results on Schizophrenia, ADHD, Depression in human brain.
Using molecular imaging, we also revealed microglial function in the brain to regulate reward system, as well as astrocyte interactions.Animal model for Schizophrenia showed the microglial malfunction by ADAM10 activation, and those protease functions related Schizophrenia was visualized by tracers of microglia for animal MRI.

Free Research Field

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Published: 2019-03-29  

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