neuroanatomical analysis of neuron-glia correlation in neuronal circuit maturation

2017 Fiscal Year Final Research Report

• Project Area: Glial assembly: a new regulatory machinery of brain function and disorders
• Project/Area Number: 25117008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: Fukuyama Hidenao 京都大学, 健康長寿社会の総合医療開発ユニット, 特任教授 (90181297)
• Co-Investigator(Kenkyū-buntansha): 植木 孝俊 名古屋市立大学, 大学院医学研究科, 教授 (60317328) ; 岡戸 晴生 公益財団法人東京都医学総合研究所, その他部局等, その他 (60221842) ; 植木 美乃 名古屋市立大学, 医学(系)研究科(研究院), 講師 (40467478)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: neuroimaging / MRI / PET / molecular imaging / microglia / connectome

Outline of Final Research Achievements

We found a lot of results on Schizophrenia, ADHD, Depression in human brain.
Using molecular imaging, we also revealed microglial function in the brain to regulate reward system, as well as astrocyte interactions.Animal model for Schizophrenia showed the microglial malfunction by ADAM10 activation, and those protease functions related Schizophrenia was visualized by tracers of microglia for animal MRI.

Free Research Field

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