多元計算解剖学の外科における臨床展開

2017 Fiscal Year Annual Research Report

• Project Area: Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy
• Project/Area Number: 26108010
• Research Institution: Kyushu University
• Principal Investigator: 橋爪 誠 九州大学, 医学研究院, 教授 (90198664)
• Co-Investigator(Kenkyū-buntansha): 家入 里志 鹿児島大学, 医歯学域医学系, 教授 (00363359) ; 宗崎 良太 九州大学, 医学研究院, 講師 (10403990) ; 大内田 研宙 九州大学, 大学病院, 講師 (20452708) ; 鈴木 直樹 東京慈恵会医科大学, 医学部, 教授 (40147327) ; 池田 典昭 九州大学, 医学研究院, 教授 (60176097) ; 小田 義直 九州大学, 医学研究院, 教授 (70291515) ; 木口 量夫 九州大学, 工学研究院, 教授 (90269548)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Keywords: 多元計算解剖学 / 医用画像 / 医用イメージング / 病理像 / 予測シミュレーション

Outline of Annual Research Achievements

今回の研究では、CTやMR像だけでなく病理像、解剖所見や肉眼所見などの臨床情報をデジタル化して集約する。基礎的な検討として、膵癌自然発症モデルマウス(KPCマウス)を用い、病理像とマイクロMR画像の統合を行うため、膵腫瘍形成前から形成後までの経時的なMR像を集積した。膵癌の悪性度診断や腫瘍増大パターンによる化学療法の治療効果を予測する為、治療群KPCマウスを作成後、同マウス膵癌より1299枚の連続病理像を作製し、HE、Ki67、CK19、MTの染色を行った。HEよりinvasive frontに絞って、管状構造を三次元構築した。癌細胞領域では多数の管状構造が見られたが、正常細胞や間質の領域では管状構造はほとんど見られなかった。また、HEよりKi67陽性細胞の予測が可能かの検討も進めており、分化型により空間的なKi67陽性細胞の分布にも差があることを見出した。また、新規統合モデルによりMR像から病理像を予測し、癌細胞の増殖能や転移能の評価にも応用しようと考えている。臨床応用として、1mmCTもしくはMRのある切除膵2例(膵癌1例と正常膵1例)からそれぞれにつき病理切片を500枚と391枚作製した。HEより管状構造を抽出し、Ki67とCK19を統合した三次元像を作製した。統合モデルを用いることで、HEより腫瘍細胞や細胞分裂が盛んな腫瘍細胞の核の分布が予測可能となると考える。病理像と経時的なCT、MR像を統合することにより、CTやMR像から病理像を予測し、悪性度診断や腫瘍の増大パターンによる術前化学療法の治療効果予測や切除後の再発の術前予測、浸潤範囲を予測できるような多元解析モデルを確立していく。さらに、動作に伴う自然な皮膚の変形を可能とする詳細な四次元全身モデルシミュレーションや、先天性横隔膜ヘルニア治療後の患児の肺の成長過程の予測モデル構築も進めている。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

KPCマウスにおいては、未治療群と抗癌剤投与群における経時的なMR像の集積が完了しており、抗癌剤投与KPCマウス膵癌組織の連続病理像においてはHE、Ki67、CK19、MTなどで染色した。HE像より管状構造を抽出し、三次元にて分布を可視化した。また、三次元HE像と三次元MR像との統合を行った。統合の自動化を進めるにあたり、膵臓周辺臓器の位置関係を元に位置合わせを試みようと考え、腹腔内臓器全体をホルマリン固定し、連続病理像の作製も行った。連続病理像においてはHE、Ki67、CK19、MT、CD31などで染色し、デジタルデータの取得を進めている。これらの集積したデジタルデータより統合モデルを構築し、MR像からの病理像を予測し、浸潤範囲や治療効果の予測モデルに応用する。また、並行してヒト切除膵を用い、連続病理像の3D構築を進めている。連続HE像より管状構造を抽出し、Ki67とCK19の3D像との統合を行った。HE病理像から癌細胞の分布や癌細胞の悪性度など細胞機能が予測可能かどうか検討している。

Strategy for Future Research Activity

KPCマウスにおいては、膵腫瘍の1区分より作製した1299枚の病理切片を3Dに再構築し、3D構築後のMR像と統合し、MR像から病理像を予測し、浸潤範囲の予測に役立てる。抗癌剤投与KPCマウスにおいては、腫瘍が縮小する領域と増大する領域とでKi67陽性細胞の分布に特徴がないかを検討する。MRや様々な病理データの統合を自動化し、予測モデルを構築する。この新規モデルを用い、MRやCT像より病理像を予測することで、腫瘍の悪性度分類が可能となり、浸潤範囲の予測によって切除範囲が決定できるようになると考える。ヒト切除膵を用いたモデルの構築では、HEの他にKi67、CK19、MTなどの間質を染色した連続病理像の三次元構築を統合した。これにより、今後はHE病理像から腫瘍の悪性度、浸潤範囲、腫瘍細胞の浸潤方向などを予測する、予測シミュレーションモデルも構築を試みる。

Research Products

• [Journal Article] Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent (2018)
  • Author(s): Kawano T, Murata M, Kang JH, Piao JS, Narahara S, Hyodo F, Hamano N, Guo J, Oguri S, Ohuchida K, Hashizume M
  • Journal Title: Biomaterials Volume: 152 Pages: 37-46
  • DOI: 10.1016/j.biomaterials.2017.10.029
  • Peer Reviewed
• [Journal Article] 総論 多元計算解剖学の確立と応用 (2018)
  • Author(s): 橋爪 誠
  • Journal Title: 細胞 Volume: 50（1） Pages: 2-4
  • Peer Reviewed
• [Journal Article] Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo 180. (2018)
  • Author(s): 12.Koikawa K, Ohuchida K, Takesue S, Ando Y, Kibe S, Nakayama H, Endo S, Abe T, Okumura T, Horikawa K, Sada M, Iwamoto C, Moriyama T, Nakata K.
  • Journal Title: Cancer Letters Volume: 412 Pages: 143-154
  • DOI: 10.1016/j.canlet.2017.10.010
  • Peer Reviewed
• [Journal Article] Feasibility of an AI-Based Measure of the Hand Motions of Expert and Novice Surgeons. (2018)
  • Author(s): 14.Uemura M, Tomikawa M, Miao T, Souzaki R, Ieiri S, Akahoshi T, Alan KL, Hashizume M
  • Journal Title: Hindawi Volume: - Pages: -
  • DOI: https://doi.org/10.1155/2018/9873273
  • Peer Reviewed
• [Journal Article] Laparoscopic Ultrasound Manipulator With aSpring-Based Elastic Mechanism. (2018)
  • Author(s): Arata J, Fukami K, Oguri S, Onogi S, Ikeda T, Nakadate R, Sakaguchi M, Akahoshi T, Harada K, Mitsuishi M, Hashizume M
  • Journal Title: Int J CARS Volume: - Pages: 印刷中
  • DOI: 10.1007/s11548-018-1709-7
  • Peer Reviewed
• [Journal Article] Comparison of Intercuneiform 1-2 Joint Mobility Between Hallux Valgus and Normal Feet Using Weightbearing Computed Tomography and 3-Dimensional Analysis (2018)
  • Author(s): Kimura.T, Kubota M, Suzuki N, Hattori A, Marumo K
  • Journal Title: Foot&Ankle International Volume: 39(3) Pages: 355?360
  • DOI: 10.1177/1071100717744174
  • Peer Reviewed
• [Journal Article] Microcystic pattern' should be recognised as part of the morphological spectrum of solid-pseudopapillary neoplasm of the pancreas (2018)
  • Author(s): Abe A, Ohishi Y, Miyazaki T, Ozono K, Mochidome N, Saeki K, Nakamura M, Oda Y
  • Journal Title: Histopathology Volume: 72(2) Pages: 216-226
  • DOI: 10.1111/his.13376
  • Peer Reviewed
• [Journal Article] 消化器癌に対するロボット手術―現状と今後の展望― (2018)
  • Author(s): 大内田研宙、橋爪 誠
  • Journal Title: 消化器外科 Volume: 41 Pages: 1-7
• [Journal Article] A new innovative laparoscopic fundoplication training simulator with a surgical skill validation system. (2017)
  • Author(s): Jimbo T, Ieiri S, Obata S, Uemura M, Souzaki R, Matsuoka N, Katayama T, Masumoto K, Hashizume M, Taguchi T
  • Journal Title: Surg Endosc Volume: 31(4) Pages: 1688-1696
  • DOI: 10.1007/s00464-016-5159-4
  • Peer Reviewed
• [Journal Article] Improving the Strength of Sutureless Laser-Assisted Vesel Repair Using Preloaded Longitudinal Compression on Tissue Edge. (2017)
  • Author(s): Nakadate R, Omori S, Ikeda T, Akahoshi T, Oguri S, Arata J, Onogi S, Hashizume M
  • Journal Title: Lasers Surg Med Volume: 49(5) Pages: 533-538
  • DOI: 10.1002/lsm.22621
  • Peer Reviewed
• [Journal Article] The usefulness of arcuate fasciculus tractography integrated navigation for glioma surgery near the language area; Clinical Investigation. (2017)
  • Author(s): Mukae N, Mizoguchi M, Mori M, Hashiguchi K, Kawaguchi M, Hata N, Amano T, Nakamizo A, Yoshimoto K, Sayama T, Iihara K, Hashizume M
  • Journal Title: Interdisciplinary Neurosurgery: Advanced Techniques and Case Management Volume: 7 Pages: 22-28
  • DOI: https://doi.org/10.1016/j.inat.2016.11.003
  • Peer Reviewed
• [Journal Article] Surgical Data Science: Enabling next-generation surgery. (2017)
  • Author(s): Maier-HL, Vedula S, Speidel S, Navab N, Kikinis R, Park A, Eisenmann M, Feussner, Frestier G, Giannarou S, Hashizume M, Katic D, Kenngott H, Kranzfelder M, Malpani A, Marz K, Neumuth T, Padoy N, Pugh C, Schoch N, Stoyanov D, Taylor R, Wagner M, Hager GD, Jannin P
  • Journal Title: Computers and Society (cs.CY) Volume: - Pages: -
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Autophagy is required for activation of pancreatic stellate cells, associated with pancreatic cancer progression and promotes growth of pancreatic tumors in mice. (2017)
  • Author(s): Endo S, Nakata K, Ohuchida K, Takesue S, Nakayama H, Abe T, Koikawa K, Okumura T, Sada M, Horioka K, Zheng B, Mizuuchi Y, Iwamoto C, Murata M, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M
  • Journal Title: Gastroenterology Volume: 152 Pages: 1492-1506
  • DOI: 10.1053/j.gastro.2017.01.010
  • Peer Reviewed
• [Journal Article] Novel imaging using a touchless display for computer-assistedgepato-biliary surgery. (2017)
  • Author(s): 7.Oshiro Y, Ohuchida K, Okada T, Hashizume M, Ohkohchi N
  • Journal Title: Surgery Today Volume: 47 Pages: 1512-1518
  • DOI: 10.1007/s00595-017-1541-7
  • Peer Reviewed
• [Journal Article] Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing invasiveness of pancreatic cancer cells. (2017)
  • Author(s): 8.Okumura T, Ohuchida K, Sada M, Abe T, Endo S, Koikawa K, Iwamoto C, Miura D, Mizuuchi Y, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Oda Y, Hashizume M, Nakamura M
  • Journal Title: Oncotarget Volume: 8 Pages: 18280-18295
  • DOI: 10.18632/oncotarget.15430
  • Peer Reviewed
• [Journal Article] Postmortem interval estimation using the animal model of postmortem gas volume changes. (2017)
  • Author(s): 9.Iwamoto C, Ohuchida K, Okumura M, Usumoto Y, Kishimoto J, Murata M, Ikeda N, Hashizume M.
  • Journal Title: Legal Medicine Volume: - Pages: 印刷中
  • DOI: 10.1016/j.legalmed.2017.12.010.
  • Peer Reviewed
• [Journal Article] A novel histological examination with dynamic 3D reconstruction from multiple immunohistochemically stained sections of a programmed cell death ligand 1-positive colon cancer. (2017)
  • Author(s): Korehisa S, Ikeda T, Okano S, Saeki H, Oki E, Oda Y, Hashizume M, Maehara Y
  • Journal Title: Histopathology Volume: 72 Pages: -
  • DOI: https://doi.org/10.1111/his.13400
  • Peer Reviewed
• [Journal Article] In vivo redox metabolic imaging of mitochondria assesses disease progression in non-alcoholic steatohepatitis. (2017)
  • Author(s): Nakata R, Hyodo F, Murata M, Eto H, Nakaji T, Kawano T, Narahara S, Yasukawa K, Akahoshi T, Tomikawa M, Hashizume M
  • Journal Title: Sci Rep Volume: 7(1) Pages: 17170
  • DOI: 10.1038/s41598-017-17447-2
  • Peer Reviewed
• [Journal Article] Successful video-assisted thoracoscopic surgery in prone position in patients with seophageal cancer and aberrant right subclavian artery: report of three cases. (2017)
  • Author(s): Shindo K, Nagai E, Nabae T, Eguchi T, Moriyama T, Ohuchida K, Manabe T, Ohtsuka T, Oda Y, Hashizume M, Nakamura M
  • Journal Title: Surg Case Rep Volume: 3(1) Pages: 86
  • DOI: 10.1186/s40792-017-0360-9
  • Peer Reviewed
• [Journal Article] Preoperative simulation unveiled undetected surgical difficulties in a case of cochlear implantation. (2017)
  • Author(s): Matsumoto N, Yamashita M, Cho B, Hashizume M
  • Journal Title: BMJ Case Rep Volume: - Pages: -
  • DOI: 10.1136/bcr-2017-222657
  • Peer Reviewed
• [Journal Article] S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma (2017)
  • Author(s): Matsunaga T, Ohtsuka T, Asano K, Kimura H, Ohuchida K, Kitada H, Ideno N, Mori Y, Tokunaga S, Oda Y, Guha S, Raimondo M, Nakamura M, Tanaka M
  • Journal Title: Pancreas Volume: 46(10) Pages: 1288-1295
  • DOI: 10.1097/MPA.0000000000000940
  • Peer Reviewed
• [Journal Article] Autophagy inhibition enhances antiproliferative effect of salinomycin in pancreatic cancer cells. (2017)
  • Author(s): Endo S, Nakata K, Sagara A, Koikawa K, Ando Y, Kibe S, Takesue S, Nakayama H, Abe T, Okumura T, Moriyama T, Miyasaka Y, Ohuchida K, Ohtsuka T, Mizumoto K, Nakamura M
  • Journal Title: Pancreatology Volume: 17(6) Pages: 990-996
  • DOI: 10.1016/j.pan.2017.08.009
  • Peer Reviewed
• [Journal Article] Degree of desmoplasia in metastatic lymph node lesions is associated with lesion size and poor prognosis in pancreatic cancer patients. Oncol Lett. (2017)
  • Author(s): Nakayama H, Ohuchida K, Yoshida M, Miyazaki T, Takesue S, Abe T, Endo S, Koikawa K, Okumura T, Moriyama T, Nakata K, Miyasaka Y, Shirahane K, Manabe T, Ohtsuka T, Toma H, Tominaga Y, Nagai E, Mizumoto K, Oda Y, Nakamura M
  • Journal Title: Oncol Lett. Volume: 14(3) Pages: 3141-3147
  • DOI: 10.3892/ol.2017.6549
  • Peer Reviewed
• [Journal Article] Feasibility and safety of modified inverted T-shaped method using linear stapler with movable cartridge fork for esophagojejunostomy following laparoscopic total gastrectomy. (2017)
  • Author(s): Ohuchida K, Nagai E, Moriyama T, Shindo K, Manabe T, Ohtsuka T, Shimizu S, Nakamura M
  • Journal Title: Transl Gastroenterol Hepatol. Volume: 2 Pages: -
  • DOI: 10.21037/tgh.2017.04.08
  • Peer Reviewed
• [Journal Article] 折り畳みノギス機構を用いた腹腔鏡下肝臓弾性計測デバイスの開発. (2017)
  • Author(s): 宮崎瑛里子、金 大永、小林英津子、李 炳南、佐久間一郎、荒田純平、橋爪 誠、近藤福雄、浅野武秀
  • Journal Title: 日本コンピュータ外科学会誌 Volume: 19（1） Pages: 27-33
  • DOI: http://doi.org/10.5759/jscas.19.27
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The incidence and outcome of allied disorders of Hirschsprung's disease in Japan: Results from a nationwide survey. (2017)
  • Author(s): Taguchi T, Ieiri S, Miyoshi K, Kohashi K, Oda Y, Kubota A, Watanabe Y, Matsufuji H, Fukuzawa M, Tomomasa T
  • Journal Title: Asian Journal of Surgery Volume: 40(1) Pages: 29-34
  • DOI: 10.1016/j.asjsur.2015.04.004
  • Peer Reviewed
• [Journal Article] Molecular Characteristics of Pancreatic Ductal Adenocarcinomas with High-Grade Pancreatic Intraepithelial Neoplasia (PanIN) Are Different from Those without High-Grade PanIN (2017)
  • Author(s): Miyazaki T, Ohishi Y, Miyasaka Y, Oda Y, Aishima S, Ozono K, Abe A, Nagai E, Nakamura M, Oda Y
  • Journal Title: Pathobiology Volume: 84(4) Pages: 192-201
  • DOI: 10.1159/000455194
  • Peer Reviewed
• [Journal Article] SLC2A1/GLUT1 expression in mural nodules of intraductal papillary mucinous neoplasm of the pancreas (2017)
  • Author(s): Oda Y, Aishima S, Shindo K, Fujino M, Mizuuchi Y, Hattori M, Miyazaki T, Tanaka M, Oda Y
  • Journal Title: Hum Pathol Volume: 65 Pages: 62-70
  • DOI: 10.1016/j.humpath.2017.03.008
  • Peer Reviewed
• [Journal Article] Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma (2017)
  • Author(s): Asayama Y, Nishie A, Ishigami K, Ushijima Y, Takayama Y, Okamoto D, Fujita N, Ohtsuka T, Yoshizumi T, Aishima S, Oda Y, Honda H
  • Journal Title: Eur Radiol Volume: 27(6) Pages: 2563-2569
  • DOI: 10.1007/s00330-016-4621-y
  • Peer Reviewed
• [Journal Article] Molecular Evidence for Monoclonal Skip Progression in Main Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas (2017)
  • Author(s): Date K, Ohtsuka T, Fujimoto T, Tamura K, Kimura H, Matsunaga T, Mochidome N, Miyazaki T, Mori Y, Oda Y, Nakamura M, Tanaka M
  • Journal Title: Ann Surg Volume: 265(5) Pages: 969-977
  • DOI: 10.1097/SLA.0000000000001755
  • Peer Reviewed
• [Journal Article] The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer (2017)
  • Author(s): Imai D, Yoshizumi T, Okano S, Uchiyama H, Ikegami T, Harimoto N, Itoh S, Soejima Y, Aishima S, Oda Y, Maehara Y
  • Journal Title: Cancer Med Volume: 6(7) Pages: 1614-1626
  • DOI: 10.1002/cam4.1087
  • Peer Reviewed
• [Journal Article] Mucinous nonneoplastic cyst of the pancreas: CT and MRI appearances (2017)
  • Author(s): Ishigami K, Nishie A, Mochidome N, Asayama Y, Ushijima Y, Kakihara D, Okamoto D, Fujita N, Ohtsuka T, Miyasaka Y, Hida T, Yoshizumi T, Honda H
  • Journal Title: Abdom Radiol Volume: 42(12) Pages: 2827-2834
  • DOI: 10.1007/s00261-017-1204-6
  • Peer Reviewed
• [Journal Article] Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients With Suspected Insulinoma (2017)
  • Author(s): Ueda K, Kawabe K, Lee L, Tachibana Y, Fujimori N, Igarashi H, Oda Y, Jensen RT, Takayanagi R, Ito T
  • Journal Title: Pancreas Volume: 46(4) Pages: 476-481
  • DOI: 10.1097/MPA.0000000000000772
  • Peer Reviewed
• [Journal Article] Bone comparison identification method based on chest computed tomography imaging (2017)
  • Author(s): Matsunobu Y, Morishita J, Usumoto Y, Okumura M, Ikeda N
  • Journal Title: Leg Med Volume: 29 Pages: 1-5
  • DOI: 10.1016/j.legalmed.2017.08.002
  • Peer Reviewed
• [Journal Article] Sex determination based on a thoracic vertebra and ribs evaluation using clinical chest radiography (2017)
  • Author(s): Tsubaki S, Morishita J, Usumoto Y, Sakaguchi K, Matsunobu Y, Kawazoe Y, Okumura M, Ikeda N
  • Journal Title: Leg Med Volume: 27 Pages: 19-24
  • DOI: 10.1016/j.legalmed.2017.06.003
  • Peer Reviewed
• [Journal Article] Analysis of postmortem changes in internal organs and gases using computed tomography data (2017)
  • Author(s): Okumura M, Usumoto Y, Tsuji A, Kudo K, Ikeda N
  • Journal Title: Leg Med Volume: 25 Pages: 11-15
  • DOI: 10.1016/j.legalmed.2016.12.011
  • Peer Reviewed
• [Journal Article] デジタル医療の神髄－コンピュータ外科学の現状－ (2017)
  • Author(s): 橋爪 誠
  • Journal Title: 日本歯科技工学会雑誌 Volume: 38(1) Pages: 6-10
• [Journal Article] Surgical data science for next-generation interventions. (2017)
  • Author(s): Lena MH, Swaroop SV, Stefanie S, Nassir N, Ron K, Adrian P, Matthias E, Hubertus F, Germain F, Stamatia G, Hashizume M, Darko K, Hannes K, Michael K, Anand M, Keno M, Thomas N, Nicolas P, Carla P, Nicolai S, Danail S, Russell T, Martin W, Gregory DH, Pierre J
  • Journal Title: Nature Biomedical Engineering Volume: 1 Pages: 691-696
  • DOI: 10.1038/s41551-017-0132-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 特集?医療・福祉・コミュニケーションロボット 本邦におけるロボット手術導入の経緯と今後の展望” ロボット (2017)
  • Author(s): 家入里志、山田耕嗣、加治 建
  • Journal Title: 日本ロボット工業会 Volume: 236 Pages: 1-5
• [Presentation] Perspectives on regulatory and ethical considerations (2018)
  • Author(s): Hashizume M
  • Organizer: The Academy of Medical Sciences (JSPS)
  • Int'l Joint Research / Invited
• [Presentation] Multidisciplinary Computational Anatomy: Concept and Clinical Application (2018)
  • Author(s): Hashizume M
  • Organizer: SPIE. Medical Imaging
  • Int'l Joint Research / Invited
• [Presentation] VR（仮想現実）技術の整形外科領域での臨床応用と可能性 (2018)
  • Author(s): 鈴木直樹
  • Organizer: 第12回日本CAOS研究会
  • Invited
• [Presentation] ダビンチ手術の現状と未来型手術支援ロボット開発 (2017)
  • Author(s): 橋爪 誠
  • Organizer: 第９回日本ロボット外科学会学術集会
  • Invited
• [Presentation] 医用画像に基づく計算解剖学の多元化と高度知能化診断・治療への展開 (2017)
  • Author(s): 橋爪 誠
  • Organizer: 第49回日本臨床分子携帯学会総会・学術集会
  • Invited
• [Presentation] AIを利用した医療応用について (2017)
  • Author(s): 橋爪 誠
  • Organizer: 第15回医療機器フォーラムプログラム
  • Invited
• [Presentation] Recent Progress of Multidisciplinary computational Anatomy (2017)
  • Author(s): Hashizume M
  • Organizer: International Forum On Medical Imaging In Asia 2017 (IFMIA2017)
  • Int'l Joint Research / Invited
• [Presentation] Clinical applications of multidisciplinary computational anatomy to surgery (2017)
  • Author(s): Hashizume M, Iwamoto C, Suzuki N, Kiguchi K, Ikeda N, Oda Y, Nakata R, Souzaki R, Ieiri S, Ohuchida K
  • Organizer: 3rd International Symposium on the Project “Multidisciplinary Computational Anatomy
  • Int'l Joint Research / Invited
• [Presentation] Keynote Presentation (2017)
  • Author(s): Hashizume M
  • Organizer: 8th International Conference on Information Processing in Computer-Assisted Interventions (IPCAI)
  • Int'l Joint Research / Invited
• [Presentation] Tissue classification of liver pathological tissue specimens image using spectral features (2017)
  • Author(s): Hashimoto E, Ishikawa M, Shinoda K, Hasegawa M, Komagata H, Kobayashi N, Mochidome N, Oda Y, Iwamoto C, Ohuchida K, Hashizume M
  • Organizer: SPIE Medical Imaging
  • Int'l Joint Research
• [Presentation] 3D Reconstruction of pancreatic ducts and collagen fibers from pathological images of pancreas serial sections (2017)
  • Author(s): Komagata H, Ishikawa M, Shinoda K, Kobayashi N, Iwamoto C, Ohuchida K, Hashizume M
  • Organizer: IEVC
  • Int'l Joint Research
• [Presentation] Accumulation and integration of various medical images derived from genetically engineered mice with pancreatic cancer (2017)
  • Author(s): Iwamoto C, Ohuchida K, Hashizume M
  • Organizer: 3rd International Symposium on the Project “Multidisciplinary Computational Anatomy
  • Int'l Joint Research
• [Presentation] The assessment of mitochondrial redox metabolism by In vivo dynamic nuclear polarization-magnetic resonance imaging for non-alcoholic steatohepatitis (2017)
  • Author(s): Nakata R, Hyodo F, Murata M, Akahoshi T, Hashizume M
  • Organizer: Digestive Disease Week 2017 (DDW 2017)
  • Int'l Joint Research
• [Presentation] Construction of multi-scale spatiotemporal model of pancreas tumor from pathology images and time series MR images (2017)
  • Author(s): Triquet V, Hontani H, Kugler M, Yokota T, Kobayashi H, Iwamono C, Ouchida K, Hashizume M
  • Organizer: Computer Assisted Radiolofy Surgery 31th International Congress and Exhibition (CARS)
  • Int'l Joint Research
• [Presentation] Forceps for measuring forces intraoperatively to acquire biological and treatment information during laparoscopic surgery (2017)
  • Author(s): Kobayashi E, Kim D, Saito K, Sato R, Hara K, Arata J, Kiguchi K, Hashizume M, Sakuma I
  • Organizer: Computer Assisted Radiolofy Surgery 31th International Congress and Exhibition (CARS)
  • Int'l Joint Research
• [Presentation] Multi-degree-of freedom Laparoscopic surgical manipulator using large deformation of elastic components (2017)
  • Author(s): Arata J, Yuki K, Oguri S, Nakadate R, Kiguchi K, Hashizume M
  • Organizer: 21st Annual Conference of the International Society for Computer Aided Surgery (ISCAS)
  • Int'l Joint Research
• [Presentation] Technical trial of GPGPU volume reconstruction by using a tablet PC for practical clinical navigation system (2017)
  • Author(s): Onogi S, Nakadate R, Arata J, Akahoshi T, Ikeda T, Hashizume M
  • Organizer: 21st Annual Conference of the International Society for Computer Aided Surgery (ISCAS)
  • Int'l Joint Research
• [Presentation] Quantitative evaluation of intestinal suture training process using forceps movement measurement from video by image processing (2017)
  • Author(s): Fukatsu N, Aoki S, Yamaguchi T, Uemura M, Hashizume M, Nakamura R
  • Organizer: 21st Annual Conference of the International Society for Computer Aided Surgery (ISCAS)
  • Int'l Joint Research
• [Presentation] Surgical navigation using intuitive image-to-patient registration for robot-assisted partial nephrectomy: clinical feasibility study. (2017)
  • Author(s): Kobayashi S, Cho B, Tatsugami K, Eto M, Hashizume M
  • Organizer: 31st International Congress and Exhibition of Computer Assisted Radiology and Surgery
  • Int'l Joint Research
• [Presentation] Development of surgical planning using a depth-adjustable drill burr for dental implant placement (2017)
  • Author(s): Cho B, Ouchida R, Hashizume M
  • Organizer: 23rd Computed Maxillofacial Imaging Congress
  • Int'l Joint Research
• [Presentation] Multichannel-near-infrared-spectroscopy-triggered Robotic Hand Rehabilitation System for Stroke Patients (2017)
  • Author(s): Lee J, Mukae N, Arata J, Iwata H, Iramina K, Iihara K, Hashizume M
  • Organizer: International Conference on Rehabilitation Robotics (ICORR 2017)
  • Int'l Joint Research
• [Presentation] SURGICAL NAVIGATION USING INTUITIVE IMAGE-TO-PATIENT REGISTRATION FOR ROBOT-ASSISTED PARTIAL NEPHRECTOMY (2017)
  • Author(s): Kobayashi S, Cho B, Tatsugami K, Hashizume M, Eto M
  • Organizer: 15th Urological Association of Asia Congress
  • Int'l Joint Research
• [Presentation] Surgical Navigation using Intuitive Image-to-Patient Registration for Robot-Assisted Partial Nephrectomy: Clinical Feasibility study. (2017)
  • Author(s): Kobayashi S, Cho B, Tatsugami K, Hashizume M, Eto M
  • Organizer: 35th Woeld Congress of Endourology
  • Int'l Joint Research
• [Presentation] BM-derived cells are involved in the tumor microenvironment and promote invasion of pancreatic cancer (2017)
  • Author(s): Iwamoto C, Ohuchida K, Okumura T, Koikawa K, Takesue S, Nakayama H, Endo S, Kibe S, Ando Y, Abe T, Miyawaki K, Murata M, Akashi K, Nakamura M, Hashizume M
  • Organizer: 48th Annual Meeting of the American Pancreatic Association
  • Int'l Joint Research
• [Presentation] The effectiveness of navigation surgery using indocyanine green fluorescent imaging for metastasectomy of lung and hepatectomy in a hepatoblastoma patient (2017)
  • Author(s): Ryota Souzaki, Yoshiaki Kinoshita, Naonori Kawakubo, Yuhki Koga, Junkichi Takemoto, Kenichi Kohashi, Yoshinao Oda, Shoichi Ohga, Tomoaki Taguchi
  • Organizer: SIOP asia
  • Int'l Joint Research
• [Presentation] The navigation surgery using indocyanine green fluorescent imaging for a hepatoblastoma patient (2017)
  • Author(s): Ryota Souzaki, Yoshiaki Kinoshita, Naonori Kawakubo, Yuhki Koga, Junkichi Takemoto, Kenichi Kohashi, Yoshinao Oda, Shoichi Ohga, Tomoaki Taguchi
  • Organizer: SIOP2017
  • Int'l Joint Research
• [Presentation] 先天性食道閉鎖症に対する胸腔鏡下根治術シュミレータ―の開発 (2017)
  • Author(s): 小幡 聡、宗崎良太、神保教広、植村宗則、松岡紀之、片山 保、家入里志、橋爪 誠、田口智章
  • Organizer: 第27回九州内視鏡下外科手術研究会
• [Presentation] 九州大学におけるロボット手術ナビゲーション開発と臨床応用 (2017)
  • Author(s): 小林 聡、宗崎良太、神保教広、植村宗則、松岡紀之、片山 保、家入里志、橋爪 誠、田口智章
  • Organizer: 第27回九州内視鏡下外科手術研究会
• [Presentation] 術中超音波による三次元再構築と可視化技術の開発 (2017)
  • Author(s): 小野木真哉、中楯 龍、荒田純平、長尾吉泰、赤星朋比古、池田哲夫、橋爪 誠
  • Organizer: 第27回九州内視鏡下外科手術研究会
• [Presentation] 手術用ナビゲーション装置として、tissue oxygen saturationとヘモグロビン量を定量イメージングするマルチスペクトルデバイスの開発と有用性の検討 (2017)
  • Author(s): 池田哲夫、堤 亮介、長原 一、沖原伸一朗、瀧口義浩、佐伯浩司、中島雄一郎、沖 英次、中楯 龍、小野木真哉、小栗 晋、前原喜彦、橋爪 誠
  • Organizer: 第11回先進内視鏡治療研究会（J-CASE）
• [Presentation] 縦方向とねじり回転が可能な軟性鏡用外付け持針器の開発 (2017)
  • Author(s): 中楯 龍、岩佐 勉、岡本康治、小野木真哉、荒田純平、小栗 晋、赤星朋比古、池田哲夫、橋爪 誠
  • Organizer: 第11回先進内視鏡治療研究会（J-CASE）