2018 Fiscal Year Annual Research Report
Clinical development in surgery of Multidisciplinary computational anatomy
Project Area | Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy |
Project/Area Number |
26108010
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Research Institution | Kyushu University |
Principal Investigator |
橋爪 誠 九州大学, 先端医療イノベーションセンター, 名誉教授 (90198664)
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Co-Investigator(Kenkyū-buntansha) |
家入 里志 鹿児島大学, 医歯学域医学系, 教授 (00363359)
宗崎 良太 九州大学, 医学研究院, 講師 (10403990)
大内田 研宙 九州大学, 大学病院, 講師 (20452708)
鈴木 直樹 東京慈恵会医科大学, 医学部, 教授 (40147327)
池田 典昭 九州大学, 医学研究院, 教授 (60176097)
小田 義直 九州大学, 医学研究院, 教授 (70291515)
木口 量夫 九州大学, 工学研究院, 教授 (90269548)
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Project Period (FY) |
2014-07-10 – 2019-03-31
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Keywords | 多元計算解剖学 / 医用画像 / 医用イメージング / 病理像 / 予測シミュレーション |
Outline of Annual Research Achievements |
本研究では、多元軸に基づく疾患治療モデルを用いた治療効果予測、ナビゲーション治療の評価およびデジタル医療技術評価システムの構築を目指している。そのために抗癌剤投与/未投与のKPCマウスモデルを作製し、治療前~治療後の経時的なマイクロMR像や連続病理像を集積した。治療効果予測の検討として、連続病理像を3次元構築し管状構造や癌細胞、Ki67陽性細胞、間質などの検出を試みた。Invasive frontでの癌細胞の浸潤の走行を検討するため、HE像よりinvasive frontに絞って、管状構造を3次元構築した。癌細胞領域では多数の管状構造が見られたが、正常なacinar cell領域や間質領域では管状構造はほとんど見られなかった。また、管状構造の方向はランダムではなく、腫瘍中央の壊死領域の表面に沿って、特定の方向に沿って伸びる分布を示した。Ki67像とHE像を3次元構築し比較したところ、未分化型の領域にKi67陽性細胞多く分布していた。分化型と未分化型の癌領域ではKi67陽性細胞の分布が空間的な分布のもとでも異なる所見を認めた。また、ホルマリン固定後のMR像と3次元HE像を統合した結果、MR像に見られるintensityの差とHE像に見られる間質の分布との間に特定の相関を認めた。この統合データに間質細胞が抽出できる3次元MT像を組み込み、病理像の定量評価による診断支援を目標に、ニューラルネットワークを基にした特徴抽出を応用して、膵癌のHE像の予測も行なった。深層学習を用いた画像解析をもとに、病理像からがん組織に特有の特徴を抽出するモデルも構築した。さらに、動作に伴う自然な皮膚の変形を可能とする詳細な四次元全身モデルシミュレーションや、先天性横隔膜ヘルニア治療後の患児の肺の成長過程の予測モデル構築も進めた。
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Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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[Journal Article] Colorectal endoscopic submucosal dissection using novel articulating devices: a comparative study in a live porcine model2019
Author(s)
Okamoto Y, Nakadate R, Nakamura S, Arata J, Oguri S, Moriyama T, Esaki M, Iwasa T, Ohuchida K, Akahoshi T, Ikeda T, Kitazono T, Hashizume M
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Journal Title
Surg Endosc
Volume: 33(2)
Pages: 651-657
DOI
Peer Reviewed
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[Journal Article] Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix2019
Author(s)
Okumura T, Ohuchida K, Kibe S, Iwamoto C, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Sada M, Horioka K, Mochidome N, Arita M, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M
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Journal Title
Int J Cancer
Volume: 144(6)
Pages: 1401-1413
DOI
Peer Reviewed
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[Journal Article] Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam2018
Author(s)
Yoshihara K, Le MN, Toizumi M, Nguyen HA, Vo HM, Odagiri T, Fujisaki S, Ariyoshi K, Moriuchi H, Hashizume M, Dang DA, Yoshida LM
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Journal Title
Influenza Other Respir Viruses
Volume: -
Pages: -
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Temperature-related mortality impacts under and beyond Paris Agreement climate change scenarios2018
Author(s)
Vicedo-Cabrera AM, Guo Y, Sera F, Huber V, Schleussner CF, Mitchell D, Tong S, de Sousa Zanotti Stagliorio Coelho M, Saldiva PHN, Lavigne E, Correa PM, Ortega NV, Kan H, Osorio S, Kysel? J, Urban A, Jaakkola JJK, Ryti NRI, Pascal M, Goodman PG, Zeka A, Michelozzi P, Scortichini M, Hashizume M, et all
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Journal Title
Clim Change
Volume: 150(3-4)
Pages: 391-402
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang, Vietnam2018
Author(s)
Althouse BM, Flasche S, Minh LN, Thiem VD, Hashizume M, Ariyoshi K, Anh DD, Rodgers GL, Klugman KP, Hu H, Yoshida LM
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Journal Title
Int J Infect Dis
Volume: 75
Pages: 18-25
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] A case of pheochromocytoma with a marked decrease in catecholamine levels after rupture in which a good outcome was achieved by elective surgery2018
Author(s)
Murai N, Azami T, Iida T, Mikura K, Imai H, Kaji M, Hashizume M, Kigawa Y, Koizumi G, Tadokoro R, Endo K, Iizaka T, Saiki R, Otsuka F, Norose T, Yamagishi M, Kurokawa I, Oike N, Sasaki H, Nagasaka S
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Journal Title
Endocr J
Volume: 65(11)
Pages: 1093-1099
DOI
Peer Reviewed
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[Journal Article] Quantifying excess deaths related to heatwaves under climate change scenarios: A multicountry time series modelling study2018
Author(s)
Guo Y, Gasparrini A, Li S, Sera F, Vicedo-Cabrera AM, de Sousa Zanotti Stagliorio Coelho M, Saldiva PHN, Lavigne E, Tawatsupa B, Punnasiri K, Overcenco A, Correa PM, Ortega NV, Kan H, Osorio S, Jaakkola JJK, Ryti NRI, Goodman PG, Zeka A, Michelozzi P, Scortichini M, Hashizume M, et all
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Journal Title
PLoS Med
Volume: 15(7)
Pages: e1002629
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Visualizing Energy Charge in Breast Carcinoma Tissues by MALDI Mass-spectrometry Imaging Profiles of Low-molecular-weight Metabolites2018
Author(s)
Torata N, Kubo M, Miura D, Ohuchida K, Mizuuchi Y, Fujimura Y, Hayakawa E, Kai M, Oda Y, Mizumoto K, Hashizume M, Nakamura M
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Journal Title
Anticancer Res
Volume: 38(7)
Pages: 4267-4272
DOI
Peer Reviewed
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[Journal Article] The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood2018
Author(s)
Ihara K, Fuchikami M, Hashizume M, Okada S, Kawai H, Obuchi S, Hirano H, Fujiwara Y, Hachisu M, Hongyong K, Morinobu S
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Journal Title
Int J Geriatr Psychiatry
Volume: 33(10)
Pages: 1312-1318
DOI
Peer Reviewed
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[Journal Article] Changing Susceptibility to Non-Optimum Temperatures in Japan, 1972-2012: The Role of Climate, Demographic, and Socioeconomic Factors2018
Author(s)
Chung Y, Yang D, Gasparrini A, Vicedo-Cabrera AM, Fook Sheng Ng C, Kim Y, Honda Y, Hashizume M
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Journal Title
Environ Health Perspect
Volume: 126(5)
Pages: 57002
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] A new robotic-assisted flexible endoscope with single-hand control: endoscopic submucosal dissection in the ex vivo porcine stomach2018
Author(s)
Iwasa T, Nakadate R, Onogi S, Okamoto Y, Arata J, Oguri S, Ogino H, Ihara E, Ohuchida K, Akahoshi T, Ikeda T, Ogawa Y, Hashizume M
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Journal Title
Surg Endosc
Volume: 32(7)
Pages: 3386-3392
DOI
Peer Reviewed
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[Journal Article] The non-linear and lagged short-term relationship between rainfall and leptospirosis and the intermediate role of floods in the Philippines2018
Author(s)
Matsushita N, Ng CFS, Kim Y, Suzuki M, Saito N, Ariyoshi K, Salva EP, Dimaano EM, Villarama JB, Go WS, Hashizume M
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Journal Title
PLoS Negl Trop Dis
Volume: 12(4)
Pages: e0006331
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma2018
Author(s)
Koikawa K, Ohuchida K, Ando Y, Kibe S, Nakayama H, Takesue S, Endo S, Abe T, Okumura T, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M
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Journal Title
Cancer Lett
Volume: 425
Pages: 65-77
DOI
Peer Reviewed
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[Journal Article] Laparoscopic ultrasound manipulator with a spring-based elastic mechanism2018
Author(s)
Arata J, Fukami K, Oguri S, Onogi S, Ikeda T, Nakadate R, Sakaguchi M, Akahoshi T, Harada K, Mitsuishi M, Hashizume M
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Journal Title
Int J Comput Assist Radiol Surg
Volume: 13(7)
Pages: 1063-1072
DOI
Peer Reviewed
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[Journal Article] A multi-country analysis on potential adaptive mechanisms to cold and heat in a changing climate2018
Author(s)
Vicedo-Cabrera AM, Sera F, Guo Y, Chung Y, Arbuthnott K, Tong S, Tobias A, Lavigne E, de Sousa Zanotti Stagliorio Coelho M, Hilario Nascimento Saldiva P, Goodman PG, Zeka A, Hashizume M, Honda Y, Kim H, Ragettli MS, R??sli M, Zanobetti A, Schwartz J, Armstrong B, Gasparrini A
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Journal Title
Environ Int
Volume: 111
Pages: 239-246
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent2018
Author(s)
Kawano T, Murata M, Kang JH, Piao JS, Narahara S, Hyodo F, Hamano N, Guo J, Oguri S, Ohuchida K, Hashizume M
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Journal Title
Biomaterials
Volume: 152
Pages: 37-46
DOI
Peer Reviewed
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[Journal Article] Mortality burden of diurnal temperature range and its temporal changes: A multi-country study2018
Author(s)
Lee W, Bell ML, Gasparrini A, Armstrong BG, Sera F, Hwang S, Lavigne E, Zanobetti A, Coelho MSZS, Saldiva PHN, Osorio S, Tobias A, Zeka A, Goodman PG, Forsberg B, Rockl?v J, Hashizume M, Honda Y, Guo YL, Seposo X, Van Dung D, Dang TN, Tong S, Guo Y, Kim H
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Journal Title
Environ Int
Volume: 110
Pages: 123-130
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo1802018
Author(s)
Koikawa K, Ohuchida K, Takesue S, Ando Y, Kibe S, Nakayama H, Endo S, Abe T, Okumura T, Horioka K, Sada M, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohuchida R, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M
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Journal Title
Cancer Lett
Volume: 412
Pages: 143-154
DOI
Peer Reviewed
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[Journal Article] Analysis of lipid raft molecules in the living brain slices2018
Author(s)
Kotani N, Nakano T, Ida Y, Ito R, Hashizume M, Yamaguchi A, Seo M, Araki T, Hojo Y, Honke K, Murakoshi T
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Journal Title
Neurochem Int
Volume: 119
Pages: 140-150
DOI
Peer Reviewed
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[Presentation] ADM are Classified Three Distinct Phenotypical Profiles Depending on its Different Microenvironment2018
Author(s)
S. Kibe, K. Ohuchida, Y. Ando, S. Takesue, M. Nakayama, T. Abe, S. Endo, K. Koikawa, T. Okumura, C. Iwamoto, K. Shindo, T. Moriyama, K. Nakata, S. Nagai, Y. Miyasaka, M. Shimamoto, T. Ohtsuka, K. Mizumoto, M. Nakamura.
Organizer
American Pancreatic Association Annual Meeting 2018
Int'l Joint Research
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[Presentation] Endo180 Expression and Histologic Categorization in Cancer Stroma is an Independent Prognostic Index in Pancreatic Cancer.2018
Author(s)
Koikawa K, Ohuchida K, Yonenaga A, Sagara A, Ando Y, Kibe S, Takesue S,Nakayama H, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Nakamura M
Organizer
APA
Int'l Joint Research
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[Presentation] NECROPTOSIS AT INVASION FRONT OF PANCREATIC CANCER CAN PROMOTE CANCER CELL MIGRATION AND INVASION2018
Author(s)
Y Ando,K Ohuchida,A Yonenaga,A Sagara,S Kibe,S Takesue,M Nakayama,K Shindo,T Moriyama,K Nakata,Y Miyasaka,T Ohtsuka,S Inoue,E Nagai,K Mizumoto,M Nakamura
Organizer
49th Annual Meeting of the APA
Int'l Joint Research
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[Presentation] The role of cancer-associated acinar atrophy via ADM-like lesion in the invasive front of pancreatic cancer2018
Author(s)
Kibe S, Ohuchida K, Ando Y, Takesue S, Nakayama M, Abe T, Endo S, Koikawa K, Okumura T, Shindo K, Moriyama T, Nakata K, Nagai S, Miyasaka Y, Ohtsuka T, Mizumoto T, Nakamura M
Organizer
Digestive Disease Week 2018
Int'l Joint Research
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[Presentation] NECROPTOSIS PROMOTES CANCER CELL MIGRATION AND INVASION IN PANCREATIC CANCER2018
Author(s)
Ando Y, Ohuchida K, Yonenaga A, Sagara A, Kibe S, Takesue S, Nakayama M, Koikawa K, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Nakamura M
Organizer
Digestive disease week 2018
Int'l Joint Research
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[Presentation] Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma2018
Author(s)
"Koikawa K, Ohuchida K, Ando Y, Kibe S, Nakayama H, Takesue S, Endo S, Abe T, Okumura T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M"
Organizer
Pancreas 2018
Int'l Joint Research
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[Presentation] BM-derived cells differentiated into multilineage hematopoietic cells regulate invasion and proliferation of pancreatic cancer2018
Author(s)
Iwamoto C, Ohuchida K, Okumura T, Koikawa K, Takesue S, Nakayama H, Endo S, Kibe S, Ando Y, Shindo K, Nakata K, Miyawaki K, Murata M, Akashi K, Nakamura M, Hashizume M
Organizer
Pancreas2018
Int'l Joint Research
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