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2018 Fiscal Year Annual Research Report

;The roles of hypoxia signaling in the pathogenesis of lifestyle related diseases

Planned Research

Project AreaOxygen biology: a new criterion for integrated understanding of life
Project/Area Number 26111003
Research InstitutionThe University of Tokyo

Principal Investigator

南学 正臣  東京大学, 医学部附属病院, 教授 (90311620)

Co-Investigator(Kenkyū-buntansha) 合田 亘人  早稲田大学, 理工学術院, 教授 (00245549)
武田 憲彦  東京大学, 医学部附属病院, 助教 (40422307)
Project Period (FY) 2014-07-10 – 2019-03-31
Keywords低酸素 / エネルギー / 炎症 / 線維化
Outline of Annual Research Achievements

臓器リモデリングによる低酸素応答機構の解析として、主な病態を形成している腎臓・心臓・肝臓の実質細胞の障害、炎症細胞の活性化、臓器の線維化に注目して、解析を進めた。
低酸素状態を in vivo で定量的に評価するため、本研究領域 飛田成史と共同研究で新規低酸素感知プローブの開発を更に進め感度と特異度を向上させるとともに、様々な腎疾患における低酸素状態とそれに伴う代謝リプログラミングとその異常に関する研究を進め、論文として報告した。
また、HIF-1αによるPDK1発現誘導、即ちActive Glycolysisが線維芽細胞においても存在することを明らかにするとともに、子宮における着床過程において、HIF-2αシグナルが必須であることを示した。その分子機構として、HIF-2αによるAdrenomedullin発現誘導が胚の子宮上皮への浸潤を誘導していることを明らかにし、論文として報告した。
無血清培養条件において線維芽細胞の活性化が誘導されることを明らかにし、その分子機構として細胞周期の低下がpost-transcriptionalにコラーゲン産生を誘導することを同定し、虚血領域における新たな線維芽細胞活性化の分子機構として論文報告した。
心臓リモデリングの過程でHIF-1α依存的に炎症惹起型マクロファージが集積し、心臓の線維化を抑制していることを明らかにした。その分子機構としてHIF-1αにより誘導されるサイトカインOncostatin-Mが線維芽細胞の活性化を抑制していることを同定した。
更に、非アルコール性脂肪性肝疾患における肝臓の代謝リプログラミングと HIF の役割に関する研究を進め、HIF-1の病態保護的保護的作用と分子レベルで解明し、これを論文化した。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

  • Research Products

    (60 results)

All 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (28 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 28 results,  Open Access: 17 results) Presentation (26 results) (of which Int'l Joint Research: 19 results,  Invited: 16 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Alessia Fornoni/University of Miami(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      Alessia Fornoni/University of Miami
  • [Int'l Joint Research] Kai-Uwe Eckardt, Juergen Floege/University of Berlin/University of Aachen(ドイツ)

    • Country Name
      GERMANY
    • Counterpart Institution
      Kai-Uwe Eckardt, Juergen Floege/University of Berlin/University of Aachen
  • [Int'l Joint Research] Roger Evans/Monash University(オーストラリア)

    • Country Name
      AUSTRALIA
    • Counterpart Institution
      Roger Evans/Monash University
  • [Int'l Joint Research] Bart Staels/Université de Lille(フランス)

    • Country Name
      FRANCE
    • Counterpart Institution
      Bart Staels/Université de Lille
  • [Int'l Joint Research] Thitinun Anusornvongchai/Lerdsin General Hospital(タイ)

    • Country Name
      THAILAND
    • Counterpart Institution
      Thitinun Anusornvongchai/Lerdsin General Hospital
  • [Journal Article] Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney2019

    • Author(s)
      Inoue Tsuyoshi、Abe Chikara、Kohro Takahide、Tanaka Shinji、Huang Liping、Yao Junlan、Zheng Shuqiu、Ye Hong、Inagi Reiko、Stornetta Ruth L.、Rosin Diane L.、Nangaku Masaomi、Wada Youichiro、Okusa Mark D.
    • Journal Title

      Kidney International

      Volume: 95 Pages: 563~576

    • DOI

      10.1016/j.kint.2018.09.020

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Placebo-Controlled, Randomized Trial of Enarodustat in Patients with Chronic Kidney Disease Followed by Long-Term Trial2019

    • Author(s)
      Akizawa Tadao、Nangaku Masaomi、Yamaguchi Takuhiro、Arai Masanobu、Koretomo Ryosuke、Matsui Atsushi、Hirakata Hideki
    • Journal Title

      American Journal of Nephrology

      Volume: 49 Pages: 165~174

    • DOI

      10.1159/000496929

    • Peer Reviewed / Open Access
  • [Journal Article] ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis2019

    • Author(s)
      Jao Tzu-Ming、Nangaku Masaomi、Wu Chia-Hsien、Sugahara Mai、Saito Hisako、Maekawa Hiroshi、Ishimoto Yu、Aoe Mari、Inoue Tsuyoshi、Tanaka Tetsuhiro、Staels Bart、Mori Kazutoshi、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 95 Pages: 577~589

    • DOI

      10.1016/j.kint.2018.09.023

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.2019

    • Author(s)
      Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nature Communications

      Volume: in press Pages: in press

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment of Novel Cells Stably Secreting Various Human IL-18 Recombinant Proteins2019

    • Author(s)
      Kumagai Asuka、Shimizu Kenji、Kurata Riho、Cui Xiaofeng、Isagawa Takayuki、Harada Masamitsu、Nagai Jun、Yoshida Yasuhiro、Ozaki Kei-ichi、Takeda Norihiko、Semba Hiroaki、Yonezawa Tomo
    • Journal Title

      Current Pharmaceutical Biotechnology

      Volume: 20 Pages: 47~55

    • DOI

      10.2174/1389201020666190206203640

    • Peer Reviewed
  • [Journal Article] Seasonal Variations in the Achievement of Guideline Targets for HbA1c, Blood Pressure, and Cholesterol Among Patients With Type 2 Diabetes: A Nationwide Population-Based Study (ABC Study JDDM49)2019

    • Author(s)
      Sakamoto Masaya、Matsutani Daisuke、Minato Soichiro、Tsujimoto Yuki、Kayama Yosuke、Takeda Norihiko、Ichikawa Seiichi、Horiuchi Ryuzo、Utsunomiya Kazunori、Nishikawa Masako
    • Journal Title

      Diabetes Care

      Volume: 42 Pages: 816~823

    • DOI

      10.2337/dc18-1953

    • Peer Reviewed
  • [Journal Article] Cell cycle perturbation induces collagen production in fibroblasts.2019

    • Author(s)
      Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
    • Journal Title

      Int Heart J.

      Volume: in press Pages: in press

    • Peer Reviewed
  • [Journal Article] Murine Model of Pulmonary Artery Overflow Vasculopathy Revealed Macrophage Accumulation in the Lung2019

    • Author(s)
      Minatsuki Shun、Takeda Norihiko、Soma Katsura、Katoh Manami、Maki Hisataka、Hatano Masaru、Takimoto Eiki、Manabe Ichiro、Komuro Issei
    • Journal Title

      International Heart Journal

      Volume: 60 Pages: 451~456

    • DOI

      10.1536/ihj.18-281

    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptional profiles in the chicken ductus arteriosus during hatching2019

    • Author(s)
      Akaike T, Shinjo S, Ohmori E, Kajimura I, Goda N, Minamisawa S
    • Journal Title

      PLoS One

      Volume: 14 Pages: e0214139

    • DOI

      10.1371/journal.pone.0214139

    • Peer Reviewed / Open Access
  • [Journal Article] Sodium?glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice2018

    • Author(s)
      Tanaka Shinji、Sugiura Yuki、Saito Hisako、Sugahara Mai、Higashijima Yoshiki、Yamaguchi Junna、Inagi Reiko、Suematsu Makoto、Nangaku Masaomi、Tanaka Tetsuhiro
    • Journal Title

      Kidney International

      Volume: 94 Pages: 912~925

    • DOI

      10.1016/j.kint.2018.04.025

    • Peer Reviewed
  • [Journal Article] Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response2018

    • Author(s)
      Anusornvongchai Thitinun、Nangaku Masaomi、Jao Tzu-Ming、Wu Chia-Hsien、Ishimoto Yu、Maekawa Hiroshi、Tanaka Tetsuhiro、Shimizu Akira、Yamamoto Masayuki、Suzuki Norio、Sassa Ryoji、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 94 Pages: 536~550

    • DOI

      10.1016/j.kint.2018.03.011

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Persistent expression of neutrophil gelatinase-associated lipocalin and M2 macrophage markers and chronic fibrosis after acute kidney injury2018

    • Author(s)
      Saito Hisako、Tanaka Tetsuhiro、Tanaka Shinji、Higashijima Yoshiki、Yamaguchi Junna、Sugahara Mai、Ito Marie、Uchida Lisa、Hasegawa Sho、Wakashima Takeshi、Fukui Kenji、Nangaku Masaomi
    • Journal Title

      Physiological Reports

      Volume: 6 Pages: e13707~e13707

    • DOI

      10.14814/phy2.13707

    • Peer Reviewed / Open Access
  • [Journal Article] Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia2018

    • Author(s)
      Hirakawa Yosuke、Mizukami Kiichi、Yoshihara Toshitada、Takahashi Ippei、Khulan Purevsuren、Honda Tomoko、Mimura Imari、Tanaka Tetsuhiro、Tobita Seiji、Nangaku Masaomi
    • Journal Title

      Kidney International

      Volume: 93 Pages: 1483~1489

    • DOI

      10.1016/j.kint.2018.01.015

    • Peer Reviewed
  • [Journal Article] Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes2018

    • Author(s)
      Mimura Imari、Hirakawa Yosuke、Kanki Yasuharu、Nakaki Ryo、Suzuki Yutaka、Tanaka Tetsuhiro、Aburatani Hiroyuki、Nangaku Masaomi
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 3779

    • DOI

      10.1038/s41598-018-22180-5

    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease2018

    • Author(s)
      Hasegawa Sho、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Current Opinion in Nephrology and Hypertension

      Volume: 27 Pages: 331~338

    • DOI

      10.1097/MNH.0000000000000431

    • Peer Reviewed
  • [Journal Article] Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis2018

    • Author(s)
      Goodwin Justin、Choi Hyunsung、Hsieh Meng-hsiung、Neugent Michael L.、Ahn Jung-Mo、Hayenga Heather N.、Singh Pankaj K.、Shackelford David B.、Lee In-Kyu、Shulaev Vladimir、Dhar Shanta、Takeda Norihiko、Kim Jung-whan
    • Journal Title

      American Journal of Respiratory Cell and Molecular Biology

      Volume: 58 Pages: 216~231

    • DOI

      10.1165/rcmb.2016-0186OC

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment2018

    • Author(s)
      Matsumoto Leona、Hirota Yasushi、Saito-Fujita Tomoko、Takeda Norihiko、Tanaka Tomoki、Hiraoka Takehiro、Akaeda Shun、Fujita Hidetoshi、Shimizu-Hirota Ryoko、Igaue Shota、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Pages: 3186~3197

    • DOI

      10.1172/JCI98931

    • Peer Reviewed / Open Access
  • [Journal Article] Visit-to-visit HbA1c variability is inversely related to baroreflex sensitivity independently of HbA1c value in type 2 diabetes2018

    • Author(s)
      Matsutani Daisuke、Sakamoto Masaya、Minato Soichiro、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
    • Journal Title

      Cardiovascular Diabetology

      Volume: 17 Pages: 100

    • DOI

      10.1186/s12933-018-0743-7

    • Peer Reviewed / Open Access
  • [Journal Article] Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation2018

    • Author(s)
      Fuji H、Ohmae S、Noma N、Takeiri M、Yasutomi H、Izumi K、Ito M、Toyomoto M、Iwaki S、Takemoto K、Seo S、Taura K、Hida S、Aoyama M、Ishihama Y、Hagiwara M、Takeda N、Hatano E、Iwaisako K、Uemoto S、Asagiri M
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Pages: 544~549

    • DOI

      10.1016/j.bbrc.2018.05.153

    • Peer Reviewed
  • [Journal Article] Effect of canagliflozin on left ventricular diastolic function in patients with type 2 diabetes2018

    • Author(s)
      Matsutani Daisuke、Sakamoto Masaya、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
    • Journal Title

      Cardiovascular Diabetology

      Volume: 17 Pages: 73

    • DOI

      10.1186/s12933-018-0717-9

    • Peer Reviewed / Open Access
  • [Journal Article] Accelerated Cardiomyocyte Proliferation in the Heart of a Neonate With LEOPARD Syndrome-Associated Fatal Cardiomyopathy2018

    • Author(s)
      Nakagama Yu、Inuzuka Ryo、Ichimura Kayoko、Hinata Munetoshi、Takehara Hiroki、Takeda Norihiko、Kakiuchi Satsuki、Shiraga Kazuhiro、Asakai Hiroko、Shindo Takahiro、Hirata Yoichiro、Saitoh Makiko、Oka Akira
    • Journal Title

      Circulation: Heart Failure

      Volume: 11 Pages: e004660

    • DOI

      10.1161/CIRCHEARTFAILURE.117.004660

    • Peer Reviewed
  • [Journal Article] Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells2018

    • Author(s)
      Yonashiro Ryo、Eguchi Kayoko、Wake Masaki、Takeda Norihiko、Nakayama Koh
    • Journal Title

      Cancer Research

      Volume: 78 Pages: 1592~1603

    • DOI

      10.1158/0008-5472.CAN-17-1751

    • Peer Reviewed / Open Access
  • [Journal Article] Combined Surgical and Medical Therapy for <i>Candida</i> Prosthetic Endocarditis in a Patient with Repaired Tetralogy of Fallot2018

    • Author(s)
      Kubota Kana、Soma Katsura、Uehara Masae、Inaba Toshiro、Saito Akihito、Takeda Norihiko、Hatano Masaru、Morita Hiroyuki、Inuzuka Ryo、Hirata Yasutaka、Yao Atsushi、Komuro Issei
    • Journal Title

      International Heart Journal

      Volume: 59 Pages: 877~880

    • DOI

      10.1536/ihj.17-314

    • Peer Reviewed / Open Access
  • [Journal Article] Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice2018

    • Author(s)
      Nakai Gaku、Shimura Daisuke、Uesugi Ken、Kajimura Ichige、Jiao Qibin、Kusakari Yoichiro、Soga Tomoyoshi、Goda Nobuhito、Minamisawa Susumu
    • Journal Title

      Heart and Vessels

      Volume: 34 Pages: 545~555

    • DOI

      10.1007/s00380-018-1293-3

    • Peer Reviewed
  • [Journal Article] HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver2018

    • Author(s)
      Arai Takatomo、Tanaka Masako、Goda Nobuhito
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 14230

    • DOI

      10.1038/s41598-018-32586-w

    • Peer Reviewed / Open Access
  • [Journal Article] Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration2018

    • Author(s)
      Miura Yasushi、Matsui Satoshi、Miyata Naoko、Harada Kenichi、Kikkawa Yamato、Ohmuraya Masaki、Araki Kimi、Tsurusaki Shinya、Okochi Hitoshi、Goda Nobuhito、Miyajima Atsushi、Tanaka Minoru
    • Journal Title

      eLife

      Volume: 7 Pages: e36572

    • DOI

      10.7554/eLife.36572

    • Peer Reviewed / Open Access
  • [Journal Article] Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women2018

    • Author(s)
      Kawanishi Noriaki、Kato Yuki、Yokozeki Kyosuke、Sawada Shuji、Sakurai Ryota、Fujiwara Yoshinori、Shinkai Shoji、Goda Nobuhito、Suzuki Katsuhiko
    • Journal Title

      Lipids in Health and Disease

      Volume: 17 Pages: 135

    • DOI

      10.1186/s12944-018-0785-6

    • Peer Reviewed / Open Access
  • [Journal Article] Loss of hypoxia inducible factor-1α aggravates γδ T-cell-mediated inflammation during acetaminophen-induced liver injury2018

    • Author(s)
      Suzuki Tomohiro、Minagawa Shoko、Yamazaki Takashi、Arai Takatomo、Kanai Mai、Shinjo Satoko、Goda Nobuhito
    • Journal Title

      Hepatology Communications

      Volume: 2 Pages: 571~581

    • DOI

      10.1002/hep4.1175

    • Peer Reviewed / Open Access
  • [Presentation] The Role of Hypoxia and HIF in Tubule Injury2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Keystone Symposium
    • Int'l Joint Research / Invited
  • [Presentation] 組織リモデリングにおける低酸素シグナル2019

    • Author(s)
      武田憲彦
    • Organizer
      第92回日本薬理学会年会
    • Invited
  • [Presentation] Roles of Ly6Chi macrophages hypoxia signaling in cardiac fibrosis2019

    • Author(s)
      Norihiko Takeda
    • Organizer
      Keystone Symposium
    • Int'l Joint Research
  • [Presentation] Diabetic Nephropathy: What is new?2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Academic Conference of 70th Establishment Anniversary of VMMU
    • Int'l Joint Research / Invited
  • [Presentation] AKI to CKD Transition2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research / Invited
  • [Presentation] The Burden of CKD; Challenges and Successes2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research / Invited
  • [Presentation] Mitochondrial DNA Leakage Causes Inflammation via the cGAS-STING Axis in Cisplatin-Mediated Tubular Damage2018

    • Author(s)
      Maekawa H, Jao T-M, Inoue R, Nishi H, Inoue T, Nangaku M, Inagi R.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
  • [Presentation] Efficacy and Safety of Daprodustat on Anemia Management in Japanese Hemodialysis Patients Not Using Erythropoiesis-Stimulating Agents2018

    • Author(s)
      Fujii T, Tsubakihara Y, Akizawa T, Nangaku M, Onoue T, Yonekawa T, Endo Y, Cobitz AR.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
  • [Presentation] Randomized, Placebo-Controlled Phase 2 Trials of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor (HIF-PHI), to Treat Anemia of CKD2018

    • Author(s)
      Nangaku M, Khawaja Z, Luo W, Garafola S, deGoma E, Komatsu Y.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
  • [Presentation] Multiple, Systemic Effects of PHD Inhibitors Signify an Anti-Fibrotic and Anti-Inflammatory Impact on Cardiovascular Complications in the Remnant Kidney2018

    • Author(s)
      Uchida L, Tanaka T, Saito H, Sugahara M, Fukui K, Wakashima T, Nangaku M.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
  • [Presentation] Mitochondrial Morphological Abnormality in Cyst Epithelial Cells of Autosomal Dominant Polycystic Kidney Disease Patients2018

    • Author(s)
      Ishimoto Y, Shimizu A, Kugita M, Nagao S, Honda K, Inagi R, Nangauk M, Nishio S, Kawano H, Horie S, Kasahara T, Osafune K, Hoshino J, Ubara Y.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
  • [Presentation] PHD Inhibition Reduces Reactive Oxidative Stress in In Vitro Ischemia Model2018

    • Author(s)
      Ito M, Tanaka T, Wakashima T, Nangaku M, Fukui K.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
  • [Presentation] Hes1, a Newly Identified Downstream Mediator of alpha7nAChR on Macrophages in the Cholinergic Anti-Inflammatory Pathway, Plays a Protective Role in AKI2018

    • Author(s)
      Inoue T, Abe C, Tanaka S, Rosin DL, Nangaku M, Wada Y, Okusa MD.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
  • [Presentation] ATF6alpha and PPARalpha Cross-Talk Provides New Insights into Lipotoxicity-Induced Tubulointerstitial Fibrosis2018

    • Author(s)
      Jao T-M, Inoue T, Sugahara M, Maekawa H, Ishimoto Y, Tanaka T, Nangaku M, Inagi R.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
  • [Presentation] The molecular mechanisms of AKI to CKD transition and its clinical implication2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Asia Pacific AKI CRRT conference
    • Int'l Joint Research / Invited
  • [Presentation] The AKI to CKD Continuum: a Clinical Perspective2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Annual Meeting of the Hong Kong Society of Nephrology
    • Int'l Joint Research / Invited
  • [Presentation] Anemia treatment in CKD: Update2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Annual Meeting of the Malaysian Society of Nephrology
    • Int'l Joint Research / Invited
  • [Presentation] 慢性腎臓病における心・血管障害2018

    • Author(s)
      南学正臣
    • Organizer
      日本下肢救済・足病学会学術集会
    • Invited
  • [Presentation] 慢性腎不全治療薬の開発 その課題と今後への期待2018

    • Author(s)
      南学正臣
    • Organizer
      日本腎臓学会
    • Invited
  • [Presentation] New insights into AKI to CKD continuum and the role of maladaptive repair2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Anuual Meeting of the Korean Society of Nephrology
    • Int'l Joint Research / Invited
  • [Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration2018

    • Author(s)
      武田憲彦
    • Organizer
      第6回低酸素研究会・酸素生物学領域国際シンポジウム
    • Invited
  • [Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration2018

    • Author(s)
      Norihiko Takeda
    • Organizer
      Hypoxia Research Meeting
    • Int'l Joint Research / Invited
  • [Presentation] Pathological role of HIF-1 in the liver2018

    • Author(s)
      合田亘人
    • Organizer
      第6回低酸素研究会・酸素生物学領域国際シンポジウム
    • Invited
  • [Presentation] Pathological role of HIF-1 in the liver2018

    • Author(s)
      Nobuhito Goda
    • Organizer
      Hypoxia Research Meeting
    • Int'l Joint Research / Invited
  • [Presentation] 自然免疫様T細胞のHIF-1による急性炎症制御機構の解明2018

    • Author(s)
      合田亘人
    • Organizer
      第91回日本生化学会
  • [Presentation] 新しい糖新生調節因子の探索とその機能解析2018

    • Author(s)
      合田亘人
    • Organizer
      第5回肝臓と糖尿病・代謝研究会
    • Invited
  • [Funded Workshop] Hypoxia Research Meeting 20182018

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Published: 2019-12-27  

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