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2018 Fiscal Year Final Research Report

Investigation of hypoxia adaptation and metabolic regulation in the cancer- and senescence-resistant rodent, the naked mole rat.

Planned Research

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Project AreaOxygen biology: a new criterion for integrated understanding of life
Project/Area Number 26111006
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKumamoto University (2018)
Hokkaido University

Principal Investigator

Miura Kyoko  熊本大学, 大学院先導機構, 准教授 (80583062)

Co-Investigator(Kenkyū-buntansha) 南嶋 洋司  群馬大学, 大学院医学系研究科, 教授 (20593966)
杉浦 悠毅  慶應義塾大学, 医学部(信濃町), 講師 (30590202)
Project Period (FY) 2014-07-10 – 2019-03-31
Keywordsハダカデバネズミ
Outline of Final Research Achievements

In this study, by interspecies comparison between naked mole rats (NMRs) and mice, we identified the upregulated or downregulated metabolic pathways, possibly contributing to the senescence-resistance of the NMR. Next, we succeeded to generate NMR-iPS cells and revealed that NMR-iPS cells have tumor-resistance. Interestingly, NMR-fibroblasts failed to reprogram in a hypoxic condition. Thus, the response of the NMR cells to oxygen condition during the reprogramming process seems to be unique. Additionally, we identified the social context-dependent brown adipose tissues thermogenesis in the NMRs.

Free Research Field

分子生物学、幹細胞学、ハダカデバネズミ学

Academic Significance and Societal Importance of the Research Achievements

長寿・老化耐性に関連すると考えられるハダカデバネズミ特有の代謝経路の動態を明らかにすることができた。これは、ヒトにおける将来の長寿化・抗老化創薬に向けた新たな介入ポイントの提示につながるものである。ハダカデバネズミにおける種特異的な初期化・発がん耐性機構を明らかにすることができた。これは将来のヒトiPS細胞の安全性の向上につながると考えられる。また、また、低酸素のみならず体温制御の観点からも、ハダカデバネズミの地下の閉鎖環境における低代謝制御戦略の一端を解明することができ、哺乳類における体温制御の多様性について理解を深めることができた。

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Published: 2020-03-30  

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