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2016 Fiscal Year Annual Research Report

情動・注意の制御に関わる大脳皮質間神経回路の適応動態

Planned Research

Project AreaMechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation
Project/Area Number 26112009
Research InstitutionTohoku University

Principal Investigator

筒井 健一郎  東北大学, 生命科学研究科, 教授 (90396466)

Co-Investigator(Kenkyū-buntansha) 泰羅 雅登  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50179397)
Project Period (FY) 2014-07-10 – 2019-03-31
Keywords神経科学 / 経頭蓋磁気刺激 / 皮質表面電位
Outline of Annual Research Achievements

情動の神経機構の解明:
前頭葉内側部の帯状回脳梁膝周囲部に対して低頻度反復経頭蓋磁気刺激を行うと、抑うつ状態が誘発されるが、前部帯状回の後方部や、前頭前野背外側部に同様の刺激を行っても、そのような変化が生じないことを、2頭のサルで明らかにした。また、機能的MRIを使った全脳計測については、コントロールとして無刺激条件での安静時脳活動を3頭のサルで計測した。
注意の神経機構の解明:
遅延反応中の前頭前野、運動前野、および、頭頂連合野からの皮質表面電位の同時記録を行うための予備的な計測(前頭連合野に対する電極シートの埋め込み、長期間に及ぶ計測の安定性のテスト)を行った。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

情動および注意の機能を調べるための大規模脳活動の計測について準備や予備的計測を行って、次年度から大量のデータを取得するための道筋をつけることができた。

Strategy for Future Research Activity

おおむね順調に進展しているので、計画に従って研究をすすめていく。

  • Research Products

    (16 results)

All 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Journal Article] Oral Administration of Methylphenidate (Ritalin) Affects Dopamine Release Differentially Between the Prefrontal Cortex and Striatum: A Microdialysis Study in the Monkey2017

    • Author(s)
      Kodama T, Kojima T, Honda Y, Hosokawa T, Tsutsui KI, Watanabe M
    • Journal Title

      Journal of Neuroscience

      Volume: 37 Pages: 2387-2394

    • DOI

      10.1523/JNEUROSCI.2155-16.2017

    • Peer Reviewed
  • [Journal Article] A dynamic code for economic object valuation in prefrontal cortex neurons2016

    • Author(s)
      Tsutsui KI, Grabenhorst F, Kobayashi S, Schultz W
    • Journal Title

      Nature Communications

      Volume: 7 Pages: 12554

    • DOI

      10.1038/ncomms12554

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neck collar for restraining head and body movements in rats for behavioral task performance and simultaneous neural activity recording2016

    • Author(s)
      Tateyama Y, Oyama K, Lo CW, Iijima T, Tsutsui KI
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 263 Pages: 68-74

    • DOI

      10.1016/j.jneumeth.2016.02.005

    • Peer Reviewed
  • [Journal Article] Comparative Overview of Visuospatial Working Memory in Monkeys and Rats2016

    • Author(s)
      Tsutsui KI, Oyama K, Nakamura S, Iijima T
    • Journal Title

      Frontiers of Systems Neuroscience

      Volume: 10 Pages: 99

    • DOI

      10.3389/fnsys.2016.00099

    • Peer Reviewed / Open Access
  • [Journal Article] Similarity in Neuronal Firing Regimes across Mammalian Species2016

    • Author(s)
      Mochizuki Y, OnagaT ... Tsutsui KI ... Shinomoto S
    • Journal Title

      Journal of Neuroscience

      Volume: 36 Pages: 5736-5747

    • DOI

      10.1523/JNEUROSCI.0230-16.2016

    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Decision related activities of anterior insular and orbitofrontal cortex in a gambling behavior of rats.2016

    • Author(s)
      Ishii H, Kaizu Y, Takahashi S, Ohara S, Tobler PN, Tsutsui KI,Iijima T
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2016-11-14
    • Int'l Joint Research
  • [Presentation] Efferent projections of the calbindinpositive entorhinal neurons in the rat: Connectional differences between the medial and lateral entorhinal cortex.2016

    • Author(s)
      Ohara S, Itou K, Shiraishi M, Gianatti M,Sota Y,Kabashima S, Onodera M,Tsutsui KI,Witter M,Iijima T
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2016-11-12
    • Int'l Joint Research
  • [Presentation] rTMSの作用機序解明および臨床利用における刺激条件最適化に向けて2016

    • Author(s)
      筒井健一郎
    • Organizer
      脳科学研究戦略推進プログラム「BMI技術」報告会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-10
    • Invited
  • [Presentation] Using transcranial magnetic stimulation (TMS) as a tool for primate neuroscience research2016

    • Author(s)
      Tsutsui KI
    • Organizer
      31st International Congress of Psychology (ICP2016)
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-25
    • Int'l Joint Research / Invited
  • [Presentation] Connectional differences between calbindin positive neurons in the medial and lateral entorhinal cortex of the rat.2016

    • Author(s)
      Ohara S,Itou K,Shiraishi M,Gianatti M,Sota Y,Kabashima S, Onodera M,Tsutsui KI,Witter M,Iijima T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-22
  • [Presentation] Connectional differences between layer Va and Vb neurons in the lateral entorhinal cortex of the rat.2016

    • Author(s)
      Onodera M, Ohara S,Shiraishi M, Itou K,Tsutsui KI, Witter M,Iijima T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-22
  • [Presentation] Inactivation of rat dorsomedial prefrontal cortex or posterior parietal cortex, but not ventromedial prefrontal cortex, impairs the performance of the visuospatial delayed response task.2016

    • Author(s)
      Oyama K,Lo CW,Tateyama Y,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
  • [Presentation] Neural correlates of abstract thought process in monkey prefrontal cortex.2016

    • Author(s)
      Hosokawa T,Nakamura S,Yamada M,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
  • [Presentation] Reduction of spontaneous physical activity and sociability induced by low-frequency repetitive transcranial stimulation (rTMS) to the lower part of the medial frontal cortex in monkeys.2016

    • Author(s)
      Nakamura S,Ogawa K,Goto Y,Hosokawa T,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
  • [Presentation] Sustained delay activity in mPFC and PPC of head-fixed rats performing delayed pro-/anti-response task.2016

    • Author(s)
      Tateyama Y,Oyama K,Lo CW,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
  • [Presentation] 反復経頭蓋磁気刺激(rTMS)によるサル内側前頭葉の情動・気分調節機能の検証2016

    • Author(s)
      筒井健一郎
    • Organizer
      第57回日本心身医学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-06-05
    • Invited

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Published: 2018-01-16  

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