2018 Fiscal Year Final Research Report
Mechanism of protein aging from the point of turbulence of nucleic acid metabolism or its exclusion mechanism.
| Project Area | Prevention of brain protein aging and dementia |
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| Project/Area Number |
26117006
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
Kakita Akiyoshi
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| Project Period (FY) |
2014-07-10 – 2019-03-31
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| Keywords | 認知症 / 筋萎縮性側索硬化症 |
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| Outline of Final Research Achievements |
Proteins that cause dementia are "transformed into pathogenic proteins and accumulated" in "selected nervous systems" with aging. This process is accompanied by "quantitative and qualitative alterations in proteins." The amount of protein is controlled by production and degradation, production is controlled by mRNA, and degradation is controlled by intracellular degradation systems and extracellular efflux mechanisms. We found that the RNA metabolism mechanism of TDP-43 causing age-related neurodegenerative diseases is disturbed. Furthermore, by disrupting RNA metabolism in vivo, we succeeded in causing fragmentation of TDP-43 and inducing apoptosis.
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| Free Research Field |
神経内科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は，TDP-43その物が持つ生理的な制御機構が，ある種の擾乱に対して極めて脆弱であり，それ故に疾患を引き起こすことを示した．この概念は，工学的なロバスト性の概念に類似している．ロバスト性と，その破綻による疾病機序は，老化に伴う疾病を包括する概念である可能性がある．今後は，このロバスト性を生かして，再び秩序を回復する治療方法を模索しうる．このような視点に立った治療方法の開発は新しく，その影響は大きい
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