2018 Fiscal Year Final Research Report
Neural mechanisms inducing plasticity on body representations
| Project Area | Understanding brain plasticity on body representations to promote their adaptive functions |
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| Project/Area Number |
26120002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | The University of Tokyo (2015-2018)
Advanced Telecommunications Research Institute International (2014) |
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Principal Investigator |
Imamizu Hiroshi 東京大学, 大学院人文社会系研究科(文学部), 教授 (30395123)
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| Co-Investigator(Kenkyū-buntansha) |
大木 紫 杏林大学, 医学部, 教授 (40223755)
前田 貴記 慶應義塾大学, 医学部(信濃町), 講師 (40296695)
村田 哲 近畿大学, 医学部, 准教授 (60246890)
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| Research Collaborator |
KATO Motoichiro
SHIBUYA Satoshi
OGAWA Kenji
ASAI Tomohisa
OKIMURA Tsukasa
YAMASHITA Yuichi
SHIGEMASU Hiroaki
KADOTA Hiroshi
YAMASHITA Masahiro
CAI Chang
OHATA Ryu
MOCHIZUKI Kei
YOSHIDA Masatoshi
IMAIZUMI Syu
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| Project Period (FY) |
2014-07-10 – 2019-03-31
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| Keywords | 身体意識 / 運動主体感 / 身体所有感 / 感覚抑制 / 随伴発射 / 統合失調症 / ラバーハンド錯覚 / 脳内身体表現 |
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| Outline of Final Research Achievements |
When humans normally move their bodies, they get sense of agency (the subjective awareness that one is excusing and controlling one’s own actions) and sense of body ownership (the awareness that one is the owner of an action or movement). Senses of agency and body ownership constitute bodily self-awareness. Our research project found that neural substrates for bodily self-awareness mainly exist in neural networks connecting the inferior parietal lobe and the inferior frontal gyrus in the right cerebral hemisphere. This finding was obtained by our behavioral experiments, measurements of brain activity, and non-invasive brain stimulation in normal human subjects as well as our analysis of neural networks in schizophrenic patients with altered bodily self-awareness. We also revealed neural mechanisms of sensory suppression, which is the basis of bodily self-awareness, by recoding activity of individual neurons in monkeys.
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| Free Research Field |
認知神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
身体意識は，人間の自我にとって重要な構成要素であるにも関わらず，極めて主観的な現象であり，科学的にアプローチしにくい研究対象であった．本研究では，ヒトの行動実験・脳活動計測，サルにおける神経細胞活動記録，統合失調症研究を組み合わせ，脳神経活動と身体意識の関係を包括的に捉えた．身体意識は，疾患や加齢による脳や身体の変化で低下する．脳神経活動の理解に基づいて，身体意識の介入・操作の基礎を構築したことは，身体意識を回復させる方法の開発に向けて大きく前進したと言える．
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