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1991 Fiscal Year Final Research Report Summary

Gene distribution of xeroderma pigmentosum in East Asia and North Africa

Research Project

Project/Area Number 01042003
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionKyoto University

Principal Investigator

TAKEBE Hiraku  Kyoto University, 医学部, 教授 (10028318)

Co-Investigator(Kenkyū-buntansha) NISHIGORI Chikako  Kyoto University, 保健診療所, 助手 (50198454)
蒋 左庶  第二軍医大学, 生物学科, 教授
朴 相大  ソウル国立大学, 自然科学部, 教授
MOHAMED Zgha  チュニス大学病院, 医師
TSUKADA Toshihiko  Kyoto University, 医学部, 助手 (10207334)
YAGI Takashi  Kyoto University, 医学部, 助教授 (80182301)
ZGHAL Mohamed  Hopital Charles Nicolle
PARK Sandai  Seoul National University
JINAG Zushou  2nd Military Medical College
Project Period (FY) 1989 – 1991
Keywordsxeroderma pigmentosum / skin cancer / sun exposure / ultraviolet light / China / Korea / Tunisia / DNA repair
Research Abstract

Gene analysis of xeroderma pigmentosum in North-East Asia and Northern Africa
Xeroderma pigmentosum is an autosomal recessively inherited disease with high incidence of skin cancer developing in the sun-exposed area of the patients. Genetic analysis revealed the presence of at least 7 genetic complementation groups and a variant type and the distribution of these groups have been shown to be different in different areas of the world. The chief investigator of this project has been analyzing the gene distribution of xeroderma pigmentosum in Japan, North America and Europe, and this project intends to extend the survey to the above-mentioned areas. Patients in China were found to be very similar to those in Japan, ih clinical manifestations, genetic distribution and DNA repair defects in theocells cultured from the patients. Patients in Korea appeared to be different in genedistribution, with essentially no patients with neurological abnormalities which are the most frequent in Japan. In Tunisia, the frequency of xeroderma pigmentosum patients was found to be approximately 10 times higher that that in Japan, presumably because of the high frequency of consanguineous marriage common in most of Arab countries. Genetic complementation analysis of the Tunisian patients identified groups A and C only, so far, similar to the previous report from Egypt. Although the latitude of Tunisia and South-Western parts of Japan is similar, patients in Tunisia were far more seriously affected, presumably due to the sunny climate and the poor medical care. Genetic analysis supported this possibility, since the genetic complementation groups in South-West Japan are similar to those in Tunisia, with similar levels of DNA repair defects against ultraviolet light induced damages associated with the disease.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Wang,S.,Nishigori,C.,Yagi,T.and Takebe,H.: "Reduced DNA repair in Progeria cells and Effects of gamma-ray irradiation on UV-induced unscheduled DNA synthsis in normal and progeria cells" Mutation Research. 256. 59-66 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yagi,T.,Tatsumi-Miyajima,J.,Sato,M.,Kraemer,K.H.and Takebe,H.: "Analysis of point mutaions in an ultraviolet-irradiated shuttle vector plasmid propagated in cells from Japanese xeroderma pigmentosum patients in complementation groups A and F" Cancer Research. 51. 3177-3182 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato,M.,Nunoshiba,T.,Nishigori,C.,Yagi,T.and Takebe,H.: "Protective effects of sodium selenite on killing and mutation by N-Methyl-N'nitrosoquanidine in E.coli" Mutation Research. 250. 73-77 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishigori,C.,Moriwaki,S.,Yagi,T.and Takebe,H.: "Altered O^6-alkylguanine DNA alkyotransferase activity in cell strains originating from mouse skin tumors induced by UV irradiation" Cancer Research. 51. 2425-2429 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Moriwaki,S.,Yagi,T.,Nishigori,C.,Imamura,S.and Takebe,H.: "Analysis of N-methyl-N-nitrosourea-induced mutations in an shuttle vector plasmid propagated in mouse O^6-methylguanine DNA methyltransferase-deficient cells in comparison with proficient cells" Cancer Research. 51. 6219-6223 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 武部 啓: "環境と遺伝" 「大学と科学」公開シンポジウム 地球環境変動の科学・かけがえのない地球を守るために. 第5回. 89-100 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 武部 啓: "がんはなぜできるか" 裳華房, 1-128 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 武部 啓(編): "ヒト培養細胞・染色体診断マニュアル" 講談社サイエンティフィク, 1-178 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wang, S. Nishigori, C., Tagi, T., and Takebe, H.: "Reduced DNA repair in progeria cells and effects of gamma-ray irradiation on UV-induced unscheduled DNA synthesis in normal and progeria cells." Mutation Research. 25l. 59-66 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi, T., Tatsumi-Miyajima, J., Sato, M., Kraemer, K. H. and Takebe, H.: "Analysis of point mutations in an ultraviolet-irradiated shuttle vector plasmid propagated in cells from Japanese xeroderma pigmentosum patients in complementation groups A and F." Cancer Research. 51. 3177-3182 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato, M., Nunoshiba, T., Nishioka, H., Yagi., and Takebe, H.: "Protective effects of sodium selenite on killing and mutation by N-methyl-N'-nitro-N-nitrosoguanidine in E. coli." Mutation Research. 250. 73-77 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishigori, C., Moriwaki, S-I., Yagi, T., and Takebe, H.: "Altered O^6-alkylguanine DNA alkyltransferase activity in cell strains originating from mouse skin tumors induced by UV irradiation." Cancer Research. 51. 2425-2429 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriwaki, S-I., Yagi, T., Nishigori, C., Imamura, S. and Takebe, H.: "Analysis of N-methyl-n-nitrosourea-induced mutations in a shuttle vector plasmid propagated in mouse O^6-methylguanine-DNA methyltransferase-deficient cells in comparison with proficient cells." Cancer Research. 51. 6219-6223 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takebe, H.: Shokabe (Tokyo). How Cancers are Produced (In Japanese), 1-128 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takebe (editor): Kodansha Scientific (Tokyo). A Manual for Diagnosis of Cellular and Chromosomal Abnormality Related Diseases (in Japanese), 1-178 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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